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• W3048752493 abstract "Abstract To evaluate the effects of l -carnitine on impaired brain function in patients with liver cirrhosis. We conducted a retrospective cohort study that included sequential 80 liver cirrhosis patients with impaired brain function evaluated using near-infrared spectroscopy (NIRS). Among them, l -carnitine was administered to 48 patients. The NIRS data and blood ammonia level at baseline and after 8 weeks of treatment were compared between patients administered with l -carnitine ( l -carnitine group) and those who were not (control group). The NIRS data at baseline were similar between the l -carnitine and control groups (0.04 ± 0.04 vs. 0.04 ± 0.05 mMmm, p = n.s), whereas those in the l -carnitine group (n = 48) were significantly better than that of the control group at 8 weeks of treatment (n = 32) (0.103 ± 0.081 vs. 0.040 ± 0.048 mMmm, p < 0.001). In the l -carnitine group, 35.4% (17/48) of patients had hyperammonemia. The NIRS data of the l -carnitine group at 8 weeks of treatment were significantly improved than that of the control group, irrespective of baseline ammonia levels (0.11 ± 0.09 vs. 0.04 ± 0.05 mMmm, p = 0.005, and 0.10 ± 0.06 vs. 0.02 ± 0.03 mMmm, p = 0.003, for normal baseline ammonia and elevated ammonia levels, respectively). In the multivariate analysis, l -carnitine administration (odds ratio [OR] 3.51, 95% confidence interval [CI] 1.23–9.99, p = 0.019) and baseline NIRS data of ≤ 0.07 mMmm (OR 5.21, 95% CI 1.69–16.0, p = 0.0041) were found as independent significant factors. l -carnitine improves impaired brain function in patients with liver cirrhosis." @default.
• W3048752493 created "2020-08-18" @default.
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• W3048752493 date "2020-08-11" @default.
• W3048752493 modified "2023-09-27" @default.
• W3048752493 title "Impaired brain function improved by l-carnitine in patients with cirrhosis: evaluation using near-infrared spectroscopy" @default.
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• W3048752493 doi "https://doi.org/10.1038/s41598-020-70585-y" @default.
• W3048752493 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7419306" @default.
• W3048752493 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32782294" @default.
• W3048752493 hasPublicationYear "2020" @default.
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