Matches in SemOpenAlex for { <https://semopenalex.org/work/W3048753310> ?p ?o ?g. }
- W3048753310 abstract "Although clinical manifestations of the 2019 novel coronavirus disease pandemic (COVID-19), caused by the novel severe acute respiratory syndrome coronavirus 2 (SARS-COV-2), are mainly respiratory symptoms, patients can also develop severe cardiovascular damage. Therefore, understanding the damage caused by SARS-COV-2 to the cardiovascular system and the underlying mechanisms is fundamental. The cardiovascular damage may be related to the imbalance of the renin-angiotensin-system (RAS) as this virus binds the Angiotensin-Converting-Enzyme 2 (ACE2), expressed on the lung alveolar epithelial cells, to enter into cells. Virus internalization may cause a downregulation of ACE2 on host cell surface that could lead to a local increased level of angiotensin II (AII) and a reduced level of angiotensin 1-7 (A1-7). An imbalance between these angiotensins may be responsible for the lung and heart damage. Pharmacological strategies that interfere with the viral attachment to ACE2 (umifenovir and hydroxychloroquine/chloroquine) or that modulate the RAS (analogous of A1-7 and ACE2, losartan) are in clinical development for COVID-19. The use of RAS inhibitors has also become a matter of public concern as these drugs may increase the mRNA expression and levels of ACE2 and impact the virulence and transmission of SARS-COV-2. Data on the effect of RAS inhibitors on ACE2 mRNA expression are scarce. Scientific societies expressed their opinion on continuing the therapy with RAS inhibitors in patients with COVID-19 and underlying cardiovascular diseases. In conclusion, RAS may play a role in SARS-COV-2-induced cardiac and pulmonary damage. Further studies are needed to better understand the role of RAS in COVID-19 and to guide decision on the use of RAS inhibitors." @default.
- W3048753310 created "2020-08-18" @default.
- W3048753310 creator A5005557373 @default.
- W3048753310 creator A5012349177 @default.
- W3048753310 creator A5040561724 @default.
- W3048753310 creator A5047162922 @default.
- W3048753310 creator A5068624791 @default.
- W3048753310 creator A5071695232 @default.
- W3048753310 creator A5084616356 @default.
- W3048753310 creator A5085334357 @default.
- W3048753310 creator A5085998598 @default.
- W3048753310 date "2020-08-11" @default.
- W3048753310 modified "2023-09-30" @default.
- W3048753310 title "Renin-Angiotensin System and Coronavirus Disease 2019: A Narrative Review" @default.
- W3048753310 cites W1580103751 @default.
- W3048753310 cites W1921613270 @default.
- W3048753310 cites W1966238900 @default.
- W3048753310 cites W1973191450 @default.
- W3048753310 cites W1978623713 @default.
- W3048753310 cites W1987665528 @default.
- W3048753310 cites W1991306589 @default.
- W3048753310 cites W2003181513 @default.
- W3048753310 cites W2007757203 @default.
- W3048753310 cites W2012289331 @default.
- W3048753310 cites W2012505332 @default.
- W3048753310 cites W2026849698 @default.
- W3048753310 cites W2029971767 @default.
- W3048753310 cites W2033190476 @default.
- W3048753310 cites W2049072124 @default.
- W3048753310 cites W2054052958 @default.
- W3048753310 cites W2061942966 @default.
- W3048753310 cites W2073587768 @default.
- W3048753310 cites W2076362159 @default.
- W3048753310 cites W2076911722 @default.
- W3048753310 cites W2081534781 @default.
- W3048753310 cites W2091671824 @default.
- W3048753310 cites W2095807050 @default.
- W3048753310 cites W2105161414 @default.
- W3048753310 cites W2112443030 @default.
- W3048753310 cites W2117648804 @default.
- W3048753310 cites W2122531690 @default.
- W3048753310 cites W2136725726 @default.
- W3048753310 cites W2139544162 @default.
- W3048753310 cites W2161477365 @default.
- W3048753310 cites W2255789882 @default.
- W3048753310 cites W2279350596 @default.
- W3048753310 cites W2405358853 @default.
- W3048753310 cites W2427094903 @default.
- W3048753310 cites W2465569946 @default.
- W3048753310 cites W2545087561 @default.
- W3048753310 cites W2550511039 @default.
- W3048753310 cites W2588199171 @default.
- W3048753310 cites W2753321278 @default.
- W3048753310 cites W2899617144 @default.
- W3048753310 cites W2914853620 @default.
- W3048753310 cites W2965141422 @default.
- W3048753310 cites W3001118548 @default.
- W3048753310 cites W3005212621 @default.
- W3048753310 cites W3005655936 @default.
- W3048753310 cites W3007643904 @default.
- W3048753310 cites W3008763357 @default.
- W3048753310 cites W3008827533 @default.
- W3048753310 cites W3009389929 @default.
- W3048753310 cites W3009828946 @default.
- W3048753310 cites W3009912996 @default.
- W3048753310 cites W3009976289 @default.
- W3048753310 cites W3010277308 @default.
- W3048753310 cites W3010350910 @default.
- W3048753310 cites W3010848803 @default.
- W3048753310 cites W3010930696 @default.
- W3048753310 cites W3010992334 @default.
- W3048753310 cites W3011176674 @default.
- W3048753310 cites W3011862945 @default.
- W3048753310 cites W3012440244 @default.
- W3048753310 cites W3012771079 @default.
- W3048753310 cites W3013302817 @default.
- W3048753310 cites W3013442544 @default.
- W3048753310 cites W3013694216 @default.
- W3048753310 cites W3013871850 @default.
- W3048753310 cites W3014086786 @default.
- W3048753310 cites W3014961459 @default.
- W3048753310 cites W3016572296 @default.
- W3048753310 cites W3017545174 @default.
- W3048753310 cites W3019406601 @default.
- W3048753310 cites W3023640683 @default.
- W3048753310 cites W3023751598 @default.
- W3048753310 cites W3024420022 @default.
- W3048753310 cites W3025099648 @default.
- W3048753310 cites W3027982050 @default.
- W3048753310 cites W3028492182 @default.
- W3048753310 cites W3028785836 @default.
- W3048753310 cites W3032939692 @default.
- W3048753310 cites W3033263367 @default.
- W3048753310 cites W3034523319 @default.
- W3048753310 cites W3217532623 @default.
- W3048753310 doi "https://doi.org/10.3389/fcvm.2020.00143" @default.
- W3048753310 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7431661" @default.
- W3048753310 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32850989" @default.
- W3048753310 hasPublicationYear "2020" @default.
- W3048753310 type Work @default.