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• W3048753816 endingPage "1197" @default.
• W3048753816 startingPage "1185" @default.
• W3048753816 abstract "Abstract Bone growth and the maintenance of bone structure are controlled by multiple endocrine and paracrine factors, including cytokines expressed locally within the bone microenvironment and those that are elevated, both locally and systemically, under inflammatory conditions. This review focuses on those bone-active cytokines that initiate JAK–STAT signaling, and outlines the discoveries made from studying skeletal defects caused by induced or spontaneous modifications in this pathway. Specifically, this review describes defects in JAK1, STAT3, and SOCS3 signaling in mouse models and in humans, including mutations designed to modify these pathways downstream of the gp130 coreceptor. It is shown that osteoclast formation is generally stimulated indirectly by these pathways through JAK1 and STAT3 actions in inflammatory and other accessory cells, including osteoblasts. In addition, in bone remodeling, osteoblast differentiation is increased secondary to stimulated osteoclast formation through an IL-6-dependent pathway. In growth plate chondrocytes, STAT3 signaling promotes the normal differentiation process that leads to bone lengthening. Within the osteoblast lineage, STAT3 signaling promotes bone formation in normal physiology and in response to mechanical loading through direct signaling in osteocytes. This activity, particularly that of the IL-6/gp130 family of cytokines, must be suppressed by SOCS3 for the normal formation of cortical bone." @default.
• W3048753816 created "2020-08-18" @default.
• W3048753816 creator A5082442667 @default.
• W3048753816 date "2020-08-01" @default.
• W3048753816 modified "2023-10-14" @default.
• W3048753816 title "The JAK1/STAT3/SOCS3 axis in bone development, physiology, and pathology" @default.
• W3048753816 cites W1508254430 @default.
• W3048753816 cites W1537488315 @default.
• W3048753816 cites W1931567843 @default.
• W3048753816 cites W1967967197 @default.
• W3048753816 cites W1970909450 @default.
• W3048753816 cites W1980986940 @default.
• W3048753816 cites W1982642777 @default.
• W3048753816 cites W1982835953 @default.
• W3048753816 cites W1987996688 @default.
• W3048753816 cites W1989296948 @default.
• W3048753816 cites W1989903786 @default.
• W3048753816 cites W1996138383 @default.
• W3048753816 cites W2000659838 @default.
• W3048753816 cites W2011787884 @default.
• W3048753816 cites W2014895887 @default.
• W3048753816 cites W2015009800 @default.
• W3048753816 cites W2015527055 @default.
• W3048753816 cites W2022819740 @default.
• W3048753816 cites W2030865745 @default.
• W3048753816 cites W2033881557 @default.
• W3048753816 cites W2035134361 @default.
• W3048753816 cites W2036988498 @default.
• W3048753816 cites W2038106655 @default.
• W3048753816 cites W2040810264 @default.
• W3048753816 cites W2040937550 @default.
• W3048753816 cites W2044503846 @default.
• W3048753816 cites W2044726772 @default.
• W3048753816 cites W2048545509 @default.
• W3048753816 cites W2054757511 @default.
• W3048753816 cites W2055162678 @default.
• W3048753816 cites W2057035809 @default.
• W3048753816 cites W2060483733 @default.
• W3048753816 cites W2066385294 @default.
• W3048753816 cites W2069284819 @default.
• W3048753816 cites W2071977541 @default.
• W3048753816 cites W2073788939 @default.
• W3048753816 cites W2084102864 @default.
• W3048753816 cites W2084150021 @default.
• W3048753816 cites W2086950922 @default.
• W3048753816 cites W2093953283 @default.
• W3048753816 cites W2096459042 @default.
• W3048753816 cites W2096987586 @default.
• W3048753816 cites W2104497596 @default.
• W3048753816 cites W2109525494 @default.
• W3048753816 cites W2112125142 @default.
• W3048753816 cites W2112757808 @default.
• W3048753816 cites W2114699576 @default.
• W3048753816 cites W2117106626 @default.
• W3048753816 cites W2117521006 @default.
• W3048753816 cites W2120855437 @default.
• W3048753816 cites W2125415295 @default.
• W3048753816 cites W2127938598 @default.
• W3048753816 cites W2136183395 @default.
• W3048753816 cites W2145612190 @default.
• W3048753816 cites W2148996267 @default.
• W3048753816 cites W2152527598 @default.
• W3048753816 cites W2153050742 @default.
• W3048753816 cites W2153869151 @default.
• W3048753816 cites W2155184084 @default.
• W3048753816 cites W2156803578 @default.
• W3048753816 cites W2162721157 @default.
• W3048753816 cites W2167234515 @default.
• W3048753816 cites W2169508444 @default.
• W3048753816 cites W2328535038 @default.
• W3048753816 cites W2485004867 @default.
• W3048753816 cites W2511863849 @default.
• W3048753816 cites W2524418520 @default.
• W3048753816 cites W2744427222 @default.
• W3048753816 cites W2750509325 @default.
• W3048753816 cites W2756262317 @default.
• W3048753816 cites W2766555128 @default.
• W3048753816 cites W2787618482 @default.
• W3048753816 cites W2800189625 @default.
• W3048753816 cites W2888777544 @default.
• W3048753816 cites W2892635078 @default.
• W3048753816 cites W2901638595 @default.
• W3048753816 cites W2916926950 @default.
• W3048753816 cites W2927572451 @default.
• W3048753816 cites W2948546250 @default.
• W3048753816 cites W2965247276 @default.
• W3048753816 cites W2966582885 @default.
• W3048753816 cites W2967168211 @default.
• W3048753816 cites W2977240403 @default.
• W3048753816 cites W2999461622 @default.
• W3048753816 cites W3006157754 @default.
• W3048753816 doi "https://doi.org/10.1038/s12276-020-0445-6" @default.
• W3048753816 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8080635" @default.
• W3048753816 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32788655" @default.
• W3048753816 hasPublicationYear "2020" @default.
• W3048753816 type Work @default.
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• W3048753816 citedByCount "43" @default.

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