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- W3048756069 abstract "In this report, we introduce a new strategy for controlling the stereochemistry in Ugi adducts. Instead of controlling stereochemistry directly during the Ugi reaction we have attempted to stereodefine the chiral center at the peptidyl position through the post-Ugi functionalization. In order to achieve this, we chose to study 2-oxo-aldehyde-derived Ugi adducts many of which partially or fully exist in the enol form that lacks the aforementioned chiral center. This in turn led to their increased nucleophilicity as compared to the standard Ugi adducts. As such, the stereocenter at the peptidyl position could be installed and stereodefined through the reaction with a suitable electrophile. Towards this end, we were able to deploy an asymmetric cinchona alkaloid-promoted electrophilic fluorination producing enantioenriched post-Ugi adducts fluorinated at the peptidyl position." @default.
- W3048756069 created "2020-08-18" @default.
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- W3048756069 date "2020-08-11" @default.
- W3048756069 modified "2023-09-27" @default.
- W3048756069 title "Controlling the stereochemistry in 2-oxo-aldehyde-derived Ugi adducts through the cinchona alkaloid-promoted electrophilic fluorination" @default.
- W3048756069 cites W1522906603 @default.
- W3048756069 cites W1548094758 @default.
- W3048756069 cites W1586245477 @default.
- W3048756069 cites W1784538610 @default.
- W3048756069 cites W1972738406 @default.
- W3048756069 cites W1984180549 @default.
- W3048756069 cites W1989887407 @default.
- W3048756069 cites W1996203458 @default.
- W3048756069 cites W1996460992 @default.
- W3048756069 cites W1996671778 @default.
- W3048756069 cites W1997564943 @default.
- W3048756069 cites W1998354440 @default.
- W3048756069 cites W2001638576 @default.
- W3048756069 cites W2006142056 @default.
- W3048756069 cites W2008719340 @default.
- W3048756069 cites W2009375412 @default.
- W3048756069 cites W2012192473 @default.
- W3048756069 cites W2014073053 @default.
- W3048756069 cites W2016766558 @default.
- W3048756069 cites W2021391363 @default.
- W3048756069 cites W2022624267 @default.
- W3048756069 cites W2030793291 @default.
- W3048756069 cites W2041655270 @default.
- W3048756069 cites W2045460958 @default.
- W3048756069 cites W2045497341 @default.
- W3048756069 cites W2050141468 @default.
- W3048756069 cites W2066273937 @default.
- W3048756069 cites W2070671669 @default.
- W3048756069 cites W2076743103 @default.
- W3048756069 cites W2080077016 @default.
- W3048756069 cites W2080830650 @default.
- W3048756069 cites W2087435464 @default.
- W3048756069 cites W2109102757 @default.
- W3048756069 cites W2111677437 @default.
- W3048756069 cites W2112146567 @default.
- W3048756069 cites W2114809965 @default.
- W3048756069 cites W2120127608 @default.
- W3048756069 cites W2121577438 @default.
- W3048756069 cites W2132733760 @default.
- W3048756069 cites W2148612285 @default.
- W3048756069 cites W2153590510 @default.
- W3048756069 cites W2158307722 @default.
- W3048756069 cites W2159293833 @default.
- W3048756069 cites W2162083881 @default.
- W3048756069 cites W2167513246 @default.
- W3048756069 cites W2169640786 @default.
- W3048756069 cites W2173540938 @default.
- W3048756069 cites W2175322377 @default.
- W3048756069 cites W2176026737 @default.
- W3048756069 cites W2218709607 @default.
- W3048756069 cites W2264719596 @default.
- W3048756069 cites W2276271541 @default.
- W3048756069 cites W2287988209 @default.
- W3048756069 cites W2316103215 @default.
- W3048756069 cites W2320637566 @default.
- W3048756069 cites W2325407346 @default.
- W3048756069 cites W2330857541 @default.
- W3048756069 cites W2340733514 @default.
- W3048756069 cites W2476582390 @default.
- W3048756069 cites W2590926059 @default.
- W3048756069 cites W2616823810 @default.
- W3048756069 cites W2759546208 @default.
- W3048756069 cites W2802088792 @default.
- W3048756069 cites W2890446973 @default.
- W3048756069 cites W2892158053 @default.
- W3048756069 cites W2900704553 @default.
- W3048756069 cites W2900819238 @default.
- W3048756069 cites W2901694569 @default.
- W3048756069 cites W2945440407 @default.
- W3048756069 cites W2949814042 @default.
- W3048756069 cites W2950696040 @default.
- W3048756069 cites W2950738401 @default.
- W3048756069 cites W2951092838 @default.
- W3048756069 cites W2951233585 @default.
- W3048756069 cites W2951854554 @default.
- W3048756069 cites W2951857995 @default.
- W3048756069 cites W2951953897 @default.
- W3048756069 cites W2953168901 @default.
- W3048756069 cites W2963890091 @default.
- W3048756069 cites W2981826716 @default.
- W3048756069 cites W3007801579 @default.
- W3048756069 cites W3008818147 @default.
- W3048756069 cites W3019266968 @default.