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• W3048759565 abstract "Significance The fibroblast growth factor–extracellular signal-regulated kinase (FGF-ERK) signaling pathway drives embryonic stem cells (ESCs) toward lineage commitment. How FGF-ERK signaling is regulated during this developmental window is poorly understood. Here we show that Profilin-2 (PFN2), an actin/dynamin-binding protein, controls FGF-ERK signaling in ESCs by regulating endocytosis. Members of the developmentally regulated miR-290 microRNA family suppress PFN2, enabling maximal FGF signaling, ESC proliferation, and ESC differentiation. These findings define a previously unknown axis of post-transcriptional control, endocytosis, and signal transduction important for ESC biology." @default.
• W3048759565 created "2020-08-18" @default.
• W3048759565 creator A5020737852 @default.
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• W3048759565 date "2020-08-11" @default.
• W3048759565 modified "2023-10-03" @default.
• W3048759565 title "MicroRNA-dependent inhibition of PFN2 orchestrates ERK activation and pluripotent state transitions by regulating endocytosis" @default.
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• W3048759565 doi "https://doi.org/10.1073/pnas.2002750117" @default.
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