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• W3048761769 abstract "The Cisplatin and its analogues are scarce for the second leading human health problem, cancer. Therefore, we have effectively engineered the PEGlyated carbon nanodots loaded with cisplatin [email protected](IV) for targeted lung cancer therapy. The [email protected](IV) confirmed by the electroscopic and spectroscopic methods. The in vitro cytotoxicity of the nanoparticles evaluated two lung cancers (A549 and HEL-299), and one non-cancerous cell line (HUVECs) were used in this study by using MTT assay. The nanoparticles are effectively killing cancer cells without affecting the nano-cancerous cells. Further, dual AO-EB fluorescent staining assay established the programmed cell death through cell morphological changes. Further, flow cytometry confirmed the induction of apoptosis by S phase arrest of the cancer cell cycle by the complexes. The results of our investigations also bear witness to [email protected](IV)+NIR-NPs promising scope and potency care management for precise cancer therapy beyond platinum drugs." @default.
• W3048761769 created "2020-08-18" @default.
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• W3048761769 date "2020-12-01" @default.
• W3048761769 modified "2023-09-27" @default.
• W3048761769 title "Near-infrared mediated polymer-coated carbon nanodots loaded cisplatin for targeted care management of lung cancer therapy" @default.
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• W3048761769 doi "https://doi.org/10.1016/j.procbio.2020.08.009" @default.
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