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- W3048762212 abstract "Abstract The gut microbiota is emerging as an important modulator of neurodegenerative diseases, and accumulating evidence has linked gut microbes to Parkinson’s disease (PD) symptomatology and pathophysiology. PD is often preceded by gastrointestinal symptoms and alterations of the enteric nervous system accompany the disease. Several studies have analyzed the gut microbiome in PD, but a consensus on the features of the PD-specific microbiota is missing. Here, we conduct a meta-analysis re-analyzing 10 currently available 16S microbiome datasets to investigate whether underlying alterations in the gut microbiota of PD patients exist. We found consistent alterations in PD-associated microbiome, which are significant and robust to confounders across studies, although differences in microbiome structure between PD and controls are limited. Enrichment of the genera Lactobacillus, Akkermansia , and Bifidobacterium and depletion of bacteria belonging to the families Lachnospiraceae and Ruminococcaceae, which are important short-chain fatty acids producers, emerged as the most consistent PD gut microbiome alterations. This dysbiosis might result in a pro-inflammatory status which could explain the recurrent gastrointestinal symptoms affecting PD patients." @default.
- W3048762212 created "2020-08-18" @default.
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- W3048762212 date "2020-08-12" @default.
- W3048762212 modified "2023-10-17" @default.
- W3048762212 title "Meta-analysis of the gut microbiome of Parkinson’s disease patients suggests alterations linked to intestinal inflammation" @default.
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- W3048762212 doi "https://doi.org/10.1101/2020.08.10.20171397" @default.
- W3048762212 hasPublicationYear "2020" @default.
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