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• W3048762911 abstract "Delineating sub-cellular mechanical properties influenced by various cellular components is a challenge in biology in health and disease. We proposed a method to statistically analyze stiffness distribution in indentation depth direction from multiple force curves measured by AFM. The stiffness distributions revealed clear depth-dependent mechanical features of cancer cells and human liver organoids treated with cell/organoid stiffening reagents, which could not be distinguished by conventional analysis that yields averaged stiffness. This work demonstrates that the analytical method is promising for evaluating heterogenous mechanical properties not only of single cell but also of multicellular tissue, and understanding of underlying stiffening mechanisms." @default.
• W3048762911 created "2020-08-18" @default.
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• W3048762911 date "2020-08-27" @default.
• W3048762911 modified "2023-10-18" @default.
• W3048762911 title "Stiffness distribution analysis in indentation depth direction reveals clear mechanical features of cells and organoids by using AFM" @default.
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• W3048762911 doi "https://doi.org/10.35848/1882-0786/abaeb5" @default.
• W3048762911 hasPublicationYear "2020" @default.
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