FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3048763317> ?p ?o ?g. }

• W3048763317 endingPage "5814" @default.
• W3048763317 startingPage "5814" @default.
• W3048763317 abstract "The natively unfolded nature of intrinsically disordered proteins (IDPs) relies on several physicochemical principles, of which the balance between a low sequence hydrophobicity and a high net charge appears to be critical. Under this premise, it is well-known that disordered proteins populate a defined region of the charge–hydropathy (C–H) space and that a linear boundary condition is sufficient to distinguish between folded and disordered proteins, an approach widely applied for the prediction of protein disorder. Nevertheless, it is evident that the C–H relation of a protein is not unalterable but can be modulated by factors extrinsic to its sequence. Here, we applied a C–H-based analysis to develop a computational approach that evaluates sequence disorder as a function of pH, assuming that both protein net charge and hydrophobicity are dependent on pH solution. On that basis, we developed DispHred, the first pH-dependent predictor of protein disorder. Despite its simplicity, DispHred displays very high accuracy in identifying pH-induced order/disorder protein transitions. DispHred might be useful for diverse applications, from the analysis of conditionally disordered segments to the synthetic design of disorder tags for biotechnological applications. Importantly, since many disorder predictors use hydrophobicity as an input, the here developed framework can be implemented in other state-of-the-art algorithms." @default.
• W3048763317 created "2020-08-18" @default.
• W3048763317 creator A5002785720 @default.
• W3048763317 creator A5022075257 @default.
• W3048763317 creator A5024812664 @default.
• W3048763317 creator A5025858582 @default.
• W3048763317 creator A5048661434 @default.
• W3048763317 date "2020-08-13" @default.
• W3048763317 modified "2023-10-16" @default.
• W3048763317 title "DispHred: A Server to Predict pH-Dependent Order–Disorder Transitions in Intrinsically Disordered Proteins" @default.
• W3048763317 cites W121768123 @default.
• W3048763317 cites W1817457239 @default.
• W3048763317 cites W1971642218 @default.
• W3048763317 cites W1975304761 @default.
• W3048763317 cites W2010622646 @default.
• W3048763317 cites W2011301426 @default.
• W3048763317 cites W2015115860 @default.
• W3048763317 cites W2019511236 @default.
• W3048763317 cites W2028215008 @default.
• W3048763317 cites W2053820259 @default.
• W3048763317 cites W2060649628 @default.
• W3048763317 cites W2070496155 @default.
• W3048763317 cites W2077135138 @default.
• W3048763317 cites W2085656056 @default.
• W3048763317 cites W2089082619 @default.
• W3048763317 cites W2102025585 @default.
• W3048763317 cites W2114823344 @default.
• W3048763317 cites W2126064524 @default.
• W3048763317 cites W2131322954 @default.
• W3048763317 cites W2131965976 @default.
• W3048763317 cites W2145773480 @default.
• W3048763317 cites W2153745204 @default.
• W3048763317 cites W2165581033 @default.
• W3048763317 cites W2294054088 @default.
• W3048763317 cites W2317656098 @default.
• W3048763317 cites W2333815586 @default.
• W3048763317 cites W2406382456 @default.
• W3048763317 cites W2510171377 @default.
• W3048763317 cites W2562860543 @default.
• W3048763317 cites W2621897082 @default.
• W3048763317 cites W2766762767 @default.
• W3048763317 cites W2777865085 @default.
• W3048763317 cites W2807958710 @default.
• W3048763317 cites W2903186346 @default.
• W3048763317 cites W2912694753 @default.
• W3048763317 cites W2937012383 @default.
• W3048763317 cites W2938874044 @default.
• W3048763317 cites W2987184424 @default.
• W3048763317 cites W2999309192 @default.
• W3048763317 cites W3000736801 @default.
• W3048763317 cites W3003247167 @default.
• W3048763317 doi "https://doi.org/10.3390/ijms21165814" @default.
• W3048763317 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7461198" @default.
• W3048763317 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32823616" @default.
• W3048763317 hasPublicationYear "2020" @default.
• W3048763317 type Work @default.
• W3048763317 sameAs 3048763317 @default.
• W3048763317 citedByCount "14" @default.
• W3048763317 countsByYear W30487633172020 @default.
• W3048763317 countsByYear W30487633172021 @default.
• W3048763317 countsByYear W30487633172022 @default.
• W3048763317 countsByYear W30487633172023 @default.
• W3048763317 crossrefType "journal-article" @default.
• W3048763317 hasAuthorship W3048763317A5002785720 @default.
• W3048763317 hasAuthorship W3048763317A5022075257 @default.
• W3048763317 hasAuthorship W3048763317A5024812664 @default.
• W3048763317 hasAuthorship W3048763317A5025858582 @default.
• W3048763317 hasAuthorship W3048763317A5048661434 @default.
• W3048763317 hasBestOaLocation W30487633171 @default.
• W3048763317 hasConcept C121332964 @default.
• W3048763317 hasConcept C14036430 @default.
• W3048763317 hasConcept C185592680 @default.
• W3048763317 hasConcept C186060115 @default.
• W3048763317 hasConcept C188082385 @default.
• W3048763317 hasConcept C2778112365 @default.
• W3048763317 hasConcept C2778815515 @default.
• W3048763317 hasConcept C41008148 @default.
• W3048763317 hasConcept C54355233 @default.
• W3048763317 hasConcept C55493867 @default.
• W3048763317 hasConcept C62520636 @default.
• W3048763317 hasConcept C70721500 @default.
• W3048763317 hasConcept C86803240 @default.
• W3048763317 hasConceptScore W3048763317C121332964 @default.
• W3048763317 hasConceptScore W3048763317C14036430 @default.
• W3048763317 hasConceptScore W3048763317C185592680 @default.
• W3048763317 hasConceptScore W3048763317C186060115 @default.
• W3048763317 hasConceptScore W3048763317C188082385 @default.
• W3048763317 hasConceptScore W3048763317C2778112365 @default.
• W3048763317 hasConceptScore W3048763317C2778815515 @default.
• W3048763317 hasConceptScore W3048763317C41008148 @default.
• W3048763317 hasConceptScore W3048763317C54355233 @default.
• W3048763317 hasConceptScore W3048763317C55493867 @default.
• W3048763317 hasConceptScore W3048763317C62520636 @default.
• W3048763317 hasConceptScore W3048763317C70721500 @default.
• W3048763317 hasConceptScore W3048763317C86803240 @default.
• W3048763317 hasIssue "16" @default.
• W3048763317 hasLocation W30487633171 @default.
• W3048763317 hasLocation W30487633172 @default.

• next