FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3048763804> ?p ?o ?g. }

• W3048763804 abstract "Detection of nucleic acids is crucial to the study of their basic properties and consequently to applying this knowledge to the determination of pathologies such as cancer. In this work, our goal is to determine new trends for creating diagnostic tools for cancer driver mutations. Herein, we study a library of natural and modified oligonucleotide duplexes by a combination of optical and theoretical methods. We report a profound effect of additives on the duplexes, including nucleic acids as an active crowder. Unpredictably and inconsistent with DNA+LNA/RNA duplexes, locked nucleic acids contribute poorly to mismatch discrimination in the DNA+LNA/DNA duplexes. We develop a theoretical framework that explains poor mismatch discrimination in KRAS oncogene. We implement our findings in a bead-bait genotyping assay to detect mutated human cancer RNA. The performance of rationally designed probes in this assay is superior to the LNA-primer polymerase chain reaction, and it agrees with sequencing data." @default.
• W3048763804 created "2020-08-18" @default.
• W3048763804 creator A5003470392 @default.
• W3048763804 creator A5036492620 @default.
• W3048763804 creator A5052279171 @default.
• W3048763804 creator A5079769072 @default.
• W3048763804 creator A5085726797 @default.
• W3048763804 date "2020-08-11" @default.
• W3048763804 modified "2023-10-16" @default.
• W3048763804 title "Optical and theoretical study of strand recognition by nucleic acid probes" @default.
• W3048763804 cites W1509445416 @default.
• W3048763804 cites W1513630408 @default.
• W3048763804 cites W1568495531 @default.
• W3048763804 cites W1699530032 @default.
• W3048763804 cites W1729822339 @default.
• W3048763804 cites W1906932503 @default.
• W3048763804 cites W1964790454 @default.
• W3048763804 cites W1967373567 @default.
• W3048763804 cites W1969967375 @default.
• W3048763804 cites W1976295152 @default.
• W3048763804 cites W1993917598 @default.
• W3048763804 cites W2012500478 @default.
• W3048763804 cites W2015501999 @default.
• W3048763804 cites W2020710960 @default.
• W3048763804 cites W2022413181 @default.
• W3048763804 cites W2026198085 @default.
• W3048763804 cites W2033729538 @default.
• W3048763804 cites W2036193631 @default.
• W3048763804 cites W2051808587 @default.
• W3048763804 cites W2059172969 @default.
• W3048763804 cites W2070511522 @default.
• W3048763804 cites W2073273766 @default.
• W3048763804 cites W2107957687 @default.
• W3048763804 cites W2108185026 @default.
• W3048763804 cites W2111388568 @default.
• W3048763804 cites W2112165051 @default.
• W3048763804 cites W2116609429 @default.
• W3048763804 cites W2131470126 @default.
• W3048763804 cites W2132602008 @default.
• W3048763804 cites W2171375066 @default.
• W3048763804 cites W2278139960 @default.
• W3048763804 cites W2291328383 @default.
• W3048763804 cites W2322817607 @default.
• W3048763804 cites W2329081549 @default.
• W3048763804 cites W2332866978 @default.
• W3048763804 cites W2342918292 @default.
• W3048763804 cites W2416752203 @default.
• W3048763804 cites W2531106686 @default.
• W3048763804 cites W2556745341 @default.
• W3048763804 cites W2557113631 @default.
• W3048763804 cites W2559001160 @default.
• W3048763804 cites W2588126420 @default.
• W3048763804 cites W2605820621 @default.
• W3048763804 cites W2615092122 @default.
• W3048763804 cites W2724428728 @default.
• W3048763804 cites W2751193807 @default.
• W3048763804 cites W2759963183 @default.
• W3048763804 cites W2783948078 @default.
• W3048763804 cites W2891457349 @default.
• W3048763804 cites W2891505724 @default.
• W3048763804 cites W2893801711 @default.
• W3048763804 cites W2900166851 @default.
• W3048763804 cites W2912744011 @default.
• W3048763804 cites W2945384510 @default.
• W3048763804 cites W2982397037 @default.
• W3048763804 cites W2990083192 @default.
• W3048763804 doi "https://doi.org/10.1038/s42004-020-00362-5" @default.
• W3048763804 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36703315" @default.
• W3048763804 hasPublicationYear "2020" @default.
• W3048763804 type Work @default.
• W3048763804 sameAs 3048763804 @default.
• W3048763804 citedByCount "5" @default.
• W3048763804 countsByYear W30487638042021 @default.
• W3048763804 countsByYear W30487638042022 @default.
• W3048763804 countsByYear W30487638042023 @default.
• W3048763804 crossrefType "journal-article" @default.
• W3048763804 hasAuthorship W3048763804A5003470392 @default.
• W3048763804 hasAuthorship W3048763804A5036492620 @default.
• W3048763804 hasAuthorship W3048763804A5052279171 @default.
• W3048763804 hasAuthorship W3048763804A5079769072 @default.
• W3048763804 hasAuthorship W3048763804A5085726797 @default.
• W3048763804 hasBestOaLocation W30487638041 @default.
• W3048763804 hasConcept C104317684 @default.
• W3048763804 hasConcept C126307556 @default.
• W3048763804 hasConcept C129312508 @default.
• W3048763804 hasConcept C135763542 @default.
• W3048763804 hasConcept C14363569 @default.
• W3048763804 hasConcept C153911025 @default.
• W3048763804 hasConcept C178790620 @default.
• W3048763804 hasConcept C185592680 @default.
• W3048763804 hasConcept C24107716 @default.
• W3048763804 hasConcept C2777563447 @default.
• W3048763804 hasConcept C2781187634 @default.
• W3048763804 hasConcept C31467283 @default.
• W3048763804 hasConcept C49105822 @default.
• W3048763804 hasConcept C501734568 @default.
• W3048763804 hasConcept C54355233 @default.
• W3048763804 hasConcept C552990157 @default.
• W3048763804 hasConcept C67705224 @default.
• W3048763804 hasConcept C70721500 @default.

• next