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- W3048763965 endingPage "120292" @default.
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- W3048763965 abstract "Mechanical signal is important for regulating stem cell fate, but the molecular mechanisms involved are unclear. Cell-matrix adhesions are important molecular mechanosensors that their formation and maturation are force-dependent processes. However, most studies focused on the role of cell contractility or substrate stiffness in these processes. How external mechanical force stimulates the formation and maturation of cell-matrix adhesions is largely unknown. Here, by using human mesenchymal stem cells (hMSCs)-collagen microtissues as a 3D model, we found that upon short-term dynamic compression, integrin αV binding, focal adhesion formation, and subsequent FAK activation, are stimulated. This compression-stimulated FAK signaling also leads to YAP activation, suggesting crosstalk between integrin-based signaling and mechanosensing. More importantly, long-term compression induces maturation of α5-integrin based adhesions to form long, slender 3D-matrix adhesions (3DMAs), which are distinct from 2D focal adhesions in composition and morphology and previously found only in cell-derived matrices and native tissues. Mechanical preconditioning hMSCs with long-term compression loading induces the formation of mature integrin α5-dependent 3DMAs and potentiates their osteogenesis. Collectively, this work shows that active mechanical stimulation can modulate cell-matrix interactions significantly at the cell-material interfaces in a dynamic manner, and affects cell fate decisions, demonstrating the significance of loading-based functional tissue engineering." @default.
- W3048763965 created "2020-08-18" @default.
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- W3048763965 date "2020-11-01" @default.
- W3048763965 modified "2023-09-30" @default.
- W3048763965 title "Mechanically induced formation and maturation of 3D-matrix adhesions (3DMAs) in human mesenchymal stem cells" @default.
- W3048763965 cites W1537236614 @default.
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- W3048763965 cites W1941703300 @default.
- W3048763965 cites W1963551339 @default.
- W3048763965 cites W1969430572 @default.
- W3048763965 cites W1976636905 @default.
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- W3048763965 cites W1994841741 @default.
- W3048763965 cites W1995977950 @default.
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- W3048763965 cites W2007097623 @default.
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- W3048763965 cites W2009383897 @default.
- W3048763965 cites W2010199370 @default.
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- W3048763965 cites W2026283108 @default.
- W3048763965 cites W2026632078 @default.
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- W3048763965 doi "https://doi.org/10.1016/j.biomaterials.2020.120292" @default.
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