FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3048764516> ?p ?o ?g. }

• W3048764516 endingPage "6084" @default.
• W3048764516 startingPage "6069" @default.
• W3048764516 abstract "Adoptive T-cell immunotherapy emerged as a powerful and promising cancer therapy, as the problem regarding the immuno-reaction between different donors and recipients can be avoided. However, this approach is challenging. After long cultivation and expansion under laboratory media conditions, T-cells are losing their viability and function due to immune checkpoint proteins, leading to decreased efficiency in killing cancer cells. Therefore, a new strategy to improve T-cell survival and function is needed. With the advantages of nanotechnology and the biocompatibility of silica-based material, silica nanocapsules (SiNCs) provide an ideal delivery system to transport therapeutic biomolecules to T-cells. Up to now, there is a lack of cellular uptake studies of nanocarriers towards T-cells.We systematically studied the influence of various physicochemical properties such as sizes, core hydrophobicities, surface charges, and surface functionalities of SiNC for their impact on cellular uptake and toxicity in CD8+ T-cells by flow cytometry and confocal laser scanning microscopy. Cytokine secretion assay was performed using the enzyme-linked immunosorbent assay. To identify suitable uptake conditions for SiNCs into CD8+ T-cells, the impact of human serum in cell culture medium was also investigated.The major impact on cellular uptake and toxicity was found to be size- and dose-dependent. Smaller sizes of SiNCs than 100 nm caused significant toxicity to the cells. It was found that the formed protein corona reduced the toxicity of the SiNCs. However, it also inhibited their uptake.Overall, we present a set of different criteria for a suitable design of nanocarriers and cell culture conditions, which need to be carefully considered for T-cell immunotherapy in vitro to facilitate uptake while avoiding toxicity." @default.
• W3048764516 created "2020-08-18" @default.
• W3048764516 creator A5004940755 @default.
• W3048764516 creator A5024668568 @default.
• W3048764516 creator A5034838011 @default.
• W3048764516 creator A5050057164 @default.
• W3048764516 creator A5070931998 @default.
• W3048764516 date "2020-08-01" @default.
• W3048764516 modified "2023-10-16" @default.
• W3048764516 title "<p>Silica Nanocapsules with Different Sizes and Physicochemical Properties as Suitable Nanocarriers for Uptake in T-Cells</p>" @default.
• W3048764516 cites W1986887325 @default.
• W3048764516 cites W1987202454 @default.
• W3048764516 cites W1996174713 @default.
• W3048764516 cites W2016431085 @default.
• W3048764516 cites W2023883866 @default.
• W3048764516 cites W203617394 @default.
• W3048764516 cites W2039395562 @default.
• W3048764516 cites W2047577853 @default.
• W3048764516 cites W2052823596 @default.
• W3048764516 cites W2057637677 @default.
• W3048764516 cites W2066783890 @default.
• W3048764516 cites W2069836641 @default.
• W3048764516 cites W2106039461 @default.
• W3048764516 cites W2117164287 @default.
• W3048764516 cites W2117981139 @default.
• W3048764516 cites W2124221877 @default.
• W3048764516 cites W2125179619 @default.
• W3048764516 cites W2132836791 @default.
• W3048764516 cites W2138715808 @default.
• W3048764516 cites W2166328120 @default.
• W3048764516 cites W2170632276 @default.
• W3048764516 cites W2172893008 @default.
• W3048764516 cites W2177773825 @default.
• W3048764516 cites W2179896505 @default.
• W3048764516 cites W2191574990 @default.
• W3048764516 cites W2277051575 @default.
• W3048764516 cites W2284550715 @default.
• W3048764516 cites W2345692168 @default.
• W3048764516 cites W2370731579 @default.
• W3048764516 cites W2425645630 @default.
• W3048764516 cites W2530156667 @default.
• W3048764516 cites W2553276534 @default.
• W3048764516 cites W2565695863 @default.
• W3048764516 cites W2581813987 @default.
• W3048764516 cites W2586592262 @default.
• W3048764516 cites W2605668593 @default.
• W3048764516 cites W2606968610 @default.
• W3048764516 cites W2616234418 @default.
• W3048764516 cites W2621290312 @default.
• W3048764516 cites W2626315766 @default.
• W3048764516 cites W2768778626 @default.
• W3048764516 cites W2771377377 @default.
• W3048764516 cites W2797530783 @default.
• W3048764516 cites W2896047396 @default.
• W3048764516 doi "https://doi.org/10.2147/ijn.s246322" @default.
• W3048764516 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7439283" @default.
• W3048764516 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32884263" @default.
• W3048764516 hasPublicationYear "2020" @default.
• W3048764516 type Work @default.
• W3048764516 sameAs 3048764516 @default.
• W3048764516 citedByCount "14" @default.
• W3048764516 countsByYear W30487645162020 @default.
• W3048764516 countsByYear W30487645162021 @default.
• W3048764516 countsByYear W30487645162022 @default.
• W3048764516 countsByYear W30487645162023 @default.
• W3048764516 crossrefType "journal-article" @default.
• W3048764516 hasAuthorship W3048764516A5004940755 @default.
• W3048764516 hasAuthorship W3048764516A5024668568 @default.
• W3048764516 hasAuthorship W3048764516A5034838011 @default.
• W3048764516 hasAuthorship W3048764516A5050057164 @default.
• W3048764516 hasAuthorship W3048764516A5070931998 @default.
• W3048764516 hasBestOaLocation W30487645161 @default.
• W3048764516 hasConcept C12554922 @default.
• W3048764516 hasConcept C153911025 @default.
• W3048764516 hasConcept C155672457 @default.
• W3048764516 hasConcept C167672396 @default.
• W3048764516 hasConcept C171250308 @default.
• W3048764516 hasConcept C178790620 @default.
• W3048764516 hasConcept C18150654 @default.
• W3048764516 hasConcept C185592680 @default.
• W3048764516 hasConcept C192562407 @default.
• W3048764516 hasConcept C203014093 @default.
• W3048764516 hasConcept C204399865 @default.
• W3048764516 hasConcept C2776090121 @default.
• W3048764516 hasConcept C2777230088 @default.
• W3048764516 hasConcept C2779178360 @default.
• W3048764516 hasConcept C2779820397 @default.
• W3048764516 hasConcept C29730261 @default.
• W3048764516 hasConcept C553184892 @default.
• W3048764516 hasConcept C86803240 @default.
• W3048764516 hasConcept C8891405 @default.
• W3048764516 hasConcept C95444343 @default.
• W3048764516 hasConceptScore W3048764516C12554922 @default.
• W3048764516 hasConceptScore W3048764516C153911025 @default.
• W3048764516 hasConceptScore W3048764516C155672457 @default.
• W3048764516 hasConceptScore W3048764516C167672396 @default.
• W3048764516 hasConceptScore W3048764516C171250308 @default.
• W3048764516 hasConceptScore W3048764516C178790620 @default.

• next