Matches in SemOpenAlex for { <https://semopenalex.org/work/W3048765587> ?p ?o ?g. }
- W3048765587 endingPage "1825" @default.
- W3048765587 startingPage "1805" @default.
- W3048765587 abstract "The EGFR tyrosine kinase inhibitor gefitinib is commonly used for lung cancer patients. However, some patients eventually become resistant to gefitinib and develop progressive disease. Here, we indicate that ecto-ATP synthase, which ectopically translocated from mitochondrial inner membrane to plasma membrane, is considered as a potential therapeutic target for drug-resistant cells. Quantitative multi-omics profiling reveals that ecto-ATP synthase inhibitor mediates CK2-dependent phosphorylation of DNA topoisomerase IIα (topo IIα) at serine 1106 and subsequently increases the expression of long noncoding RNA, GAS5. Additionally, we also determine that downstream of GAS5, p53 pathway, is activated by ecto-ATP synthase inhibitor for regulation of programed cell death. Interestingly, GAS5-proteins interactomic profiling elucidates that GAS5 associates with topo IIα and subsequently enhancing the phosphorylation level of topo IIα. Taken together, our findings suggest that ecto-ATP synthase blockade is an effective therapeutic strategy via regulation of CK2/phospho-topo IIα/GAS5 network in gefitinib-resistant lung cancer cells." @default.
- W3048765587 created "2020-08-18" @default.
- W3048765587 creator A5005206049 @default.
- W3048765587 creator A5006601049 @default.
- W3048765587 creator A5033886049 @default.
- W3048765587 creator A5035528811 @default.
- W3048765587 creator A5041370934 @default.
- W3048765587 creator A5052313712 @default.
- W3048765587 date "2020-11-01" @default.
- W3048765587 modified "2023-09-25" @default.
- W3048765587 title "Multiomics Reveals Ectopic ATP Synthase Blockade Induces Cancer Cell Death via a lncRNA-mediated Phospho-signaling Network" @default.
- W3048765587 cites W1482412291 @default.
- W3048765587 cites W1528730016 @default.
- W3048765587 cites W1650797637 @default.
- W3048765587 cites W1864729394 @default.
- W3048765587 cites W1964412220 @default.
- W3048765587 cites W1968442592 @default.
- W3048765587 cites W1970527559 @default.
- W3048765587 cites W1973179542 @default.
- W3048765587 cites W1978509911 @default.
- W3048765587 cites W1981153918 @default.
- W3048765587 cites W1981619531 @default.
- W3048765587 cites W1983213855 @default.
- W3048765587 cites W1986656413 @default.
- W3048765587 cites W1992473001 @default.
- W3048765587 cites W1996931402 @default.
- W3048765587 cites W1998081249 @default.
- W3048765587 cites W1999746344 @default.
- W3048765587 cites W2003985440 @default.
- W3048765587 cites W2005968922 @default.
- W3048765587 cites W2007401366 @default.
- W3048765587 cites W2007743089 @default.
- W3048765587 cites W2014484940 @default.
- W3048765587 cites W2015000811 @default.
- W3048765587 cites W2021168471 @default.
- W3048765587 cites W2035618305 @default.
- W3048765587 cites W2036321220 @default.
- W3048765587 cites W2037873277 @default.
- W3048765587 cites W2039291069 @default.
- W3048765587 cites W2041051519 @default.
- W3048765587 cites W2042355233 @default.
- W3048765587 cites W2043696829 @default.
- W3048765587 cites W2052039819 @default.
- W3048765587 cites W2054616484 @default.
- W3048765587 cites W2055402151 @default.
- W3048765587 cites W2060737324 @default.
- W3048765587 cites W2063131548 @default.
- W3048765587 cites W2063607976 @default.
- W3048765587 cites W2063669247 @default.
- W3048765587 cites W2066288680 @default.
- W3048765587 cites W2070011883 @default.
- W3048765587 cites W2077506183 @default.
- W3048765587 cites W2079210988 @default.
- W3048765587 cites W2079888012 @default.
- W3048765587 cites W2080352379 @default.
- W3048765587 cites W2080752012 @default.
- W3048765587 cites W2085364628 @default.
- W3048765587 cites W2087377443 @default.
- W3048765587 cites W2091161969 @default.
- W3048765587 cites W2092299925 @default.
- W3048765587 cites W2095618958 @default.
- W3048765587 cites W2095988647 @default.
- W3048765587 cites W2099955070 @default.
- W3048765587 cites W2100794900 @default.
- W3048765587 cites W2102304447 @default.
- W3048765587 cites W2104726963 @default.
- W3048765587 cites W2105869859 @default.
- W3048765587 cites W2110321876 @default.
- W3048765587 cites W2115260093 @default.
- W3048765587 cites W2116992267 @default.
- W3048765587 cites W2120865735 @default.
- W3048765587 cites W2121389354 @default.
- W3048765587 cites W2124624490 @default.
- W3048765587 cites W2126004255 @default.
- W3048765587 cites W2128059540 @default.
- W3048765587 cites W2128088579 @default.
- W3048765587 cites W2130410032 @default.
- W3048765587 cites W2132444060 @default.
- W3048765587 cites W2133959309 @default.
- W3048765587 cites W2136946165 @default.
- W3048765587 cites W2139756299 @default.
- W3048765587 cites W2141540898 @default.
- W3048765587 cites W2143859186 @default.
- W3048765587 cites W2146512944 @default.
- W3048765587 cites W2154969724 @default.
- W3048765587 cites W2159013299 @default.
- W3048765587 cites W2161483818 @default.
- W3048765587 cites W2161821474 @default.
- W3048765587 cites W2162690902 @default.
- W3048765587 cites W2169359398 @default.
- W3048765587 cites W2175830459 @default.
- W3048765587 cites W2196835862 @default.
- W3048765587 cites W2198153867 @default.
- W3048765587 cites W2220553089 @default.
- W3048765587 cites W2331413585 @default.
- W3048765587 cites W2333384502 @default.
- W3048765587 cites W2473744573 @default.
- W3048765587 cites W2564521303 @default.