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- W3048770073 abstract "Several pathological disorders have known linkages with the misfolding and abnormal oligomerization of peptides and proteins and their accumulation into numerous aggregates. One such peptide is human islet amyloid polypeptide (hIAPP) responsible for amyloid aggregation in type 2 diabetes. This aggregation can be altered by osmolytes, which are natural agents that can alter the environment surrounding of hIAPP. Here, we implemented several replica-exchange molecular dynamics (REMD) simulations to examine the effects of the denaturing osmolyte urea and the protective osmolyte trimethylamine N-oxide (TMAO) on amyloid aggregation and on the conformational ensemble of the hIAPP peptide. We analyzed specific modulations in hIAPP peptide and observed a state shift in the conformational population of hIAPP. Our results confirmed that urea restricted the peptide aggregation and led to the formation of unfolded conformations, whereas TMAO promoted folding and a compact state of the hIAPP peptide." @default.
- W3048770073 created "2020-08-18" @default.
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- W3048770073 creator A5084849731 @default.
- W3048770073 creator A5091391140 @default.
- W3048770073 date "2020-12-01" @default.
- W3048770073 modified "2023-09-23" @default.
- W3048770073 title "Assessing the role of osmolytes on the conformational harmony of islet amyloid polypeptide" @default.
- W3048770073 cites W1031578623 @default.
- W3048770073 cites W1607242112 @default.
- W3048770073 cites W1629766434 @default.
- W3048770073 cites W1963819448 @default.
- W3048770073 cites W1969175350 @default.
- W3048770073 cites W1971210425 @default.
- W3048770073 cites W1971765720 @default.
- W3048770073 cites W1972011321 @default.
- W3048770073 cites W1972751092 @default.
- W3048770073 cites W1976499671 @default.
- W3048770073 cites W1977614563 @default.
- W3048770073 cites W1979156580 @default.
- W3048770073 cites W1979493456 @default.
- W3048770073 cites W1986115510 @default.
- W3048770073 cites W1991794210 @default.
- W3048770073 cites W1991877201 @default.
- W3048770073 cites W2000483769 @default.
- W3048770073 cites W2001152577 @default.
- W3048770073 cites W2001384706 @default.
- W3048770073 cites W2006708449 @default.
- W3048770073 cites W2007566093 @default.
- W3048770073 cites W2015068531 @default.
- W3048770073 cites W2018576283 @default.
- W3048770073 cites W2025595434 @default.
- W3048770073 cites W2026353483 @default.
- W3048770073 cites W2031168104 @default.
- W3048770073 cites W2032363535 @default.
- W3048770073 cites W2035266068 @default.
- W3048770073 cites W2035687084 @default.
- W3048770073 cites W2037076861 @default.
- W3048770073 cites W2038771674 @default.
- W3048770073 cites W2047168931 @default.
- W3048770073 cites W2049000003 @default.
- W3048770073 cites W2051588845 @default.
- W3048770073 cites W2052162433 @default.
- W3048770073 cites W2053576042 @default.
- W3048770073 cites W2059013803 @default.
- W3048770073 cites W2063431000 @default.
- W3048770073 cites W2063464611 @default.
- W3048770073 cites W2065232574 @default.
- W3048770073 cites W2068475565 @default.
- W3048770073 cites W2072886986 @default.
- W3048770073 cites W2073122429 @default.
- W3048770073 cites W2087579391 @default.
- W3048770073 cites W2089084617 @default.
- W3048770073 cites W2097259690 @default.
- W3048770073 cites W2098651156 @default.
- W3048770073 cites W2103945336 @default.
- W3048770073 cites W2108711777 @default.
- W3048770073 cites W2116888800 @default.
- W3048770073 cites W2118608964 @default.
- W3048770073 cites W2119141718 @default.
- W3048770073 cites W2150766477 @default.
- W3048770073 cites W2156576736 @default.
- W3048770073 cites W2169693347 @default.
- W3048770073 cites W2275283697 @default.
- W3048770073 cites W2283130574 @default.
- W3048770073 cites W2318556941 @default.
- W3048770073 cites W2322256054 @default.
- W3048770073 cites W2322443567 @default.
- W3048770073 cites W2324735944 @default.
- W3048770073 cites W2327524320 @default.
- W3048770073 cites W2346388377 @default.
- W3048770073 cites W2526834555 @default.
- W3048770073 cites W2560453571 @default.
- W3048770073 cites W2580969766 @default.
- W3048770073 cites W2597394997 @default.
- W3048770073 cites W2754321314 @default.
- W3048770073 cites W2766559006 @default.
- W3048770073 cites W2773529668 @default.
- W3048770073 cites W2791011305 @default.
- W3048770073 cites W2791850186 @default.
- W3048770073 cites W2800890481 @default.
- W3048770073 cites W2802954113 @default.
- W3048770073 cites W2907093370 @default.
- W3048770073 cites W2912515977 @default.
- W3048770073 cites W2944741850 @default.
- W3048770073 cites W2951701336 @default.
- W3048770073 cites W2962908930 @default.
- W3048770073 cites W2963358781 @default.
- W3048770073 doi "https://doi.org/10.1016/j.ijbiomac.2020.08.104" @default.
- W3048770073 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32800950" @default.
- W3048770073 hasPublicationYear "2020" @default.
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