FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W304877180> ?p ?o ?g. }

• W304877180 abstract "Dazoxiben , an imidazole-derived selective inhibitor of thromboxane A2 (TxA2) synthetase, prevented TxB2 synthesis in vitro in platelet-rich plasma from 16 normal subjects. Inhibition of TxB2 synthesis was accompanied by increased generation of PGE2, PGF2 alpha, and PGD2, as shown by radioimmunoassay, thin-layer radiochromatography, and high- resolution gas chromatography-mass spectrometry. Even at dazoxiben concentrations (40–80 microM) above those inhibiting TxB2 synthesis, platelet aggregation induced by threshold concentrations of arachidonic acid was inhibited in only 4 of 16 subjects, referred to as responders. The remaining 12 individuals were defined as nonresponders. The aggregating effect of arachidonic acid and of the prostaglandin- endoperoxide analog U-46619 was potentiated by PGE2 and prevented by PGD2 at concentrations within the range of those detected in dazoxiben - treated platelet-rich plasma. The antiaggregating effect of dazoxiben was counteracted by PGE2 (in responders) and was potentiated by PGD2 (in nonresponders). Platelets from responders and nonresponders did not differ in the amount of immunoreactive PGE2 material or in their sensitivity to U-46619 or PGD2. It is concluded that inhibition of thromboxane synthetase does not per se prevent platelet aggregation. The functional result of thromboxane suppression appears to be modulated by an interplay of the prostaglandin-endoperoxides, PGE2 and PGD2, which are formed in excess." @default.
• W304877180 created "2016-06-24" @default.
• W304877180 creator A5013871815 @default.
• W304877180 creator A5033092400 @default.
• W304877180 creator A5039927165 @default.
• W304877180 creator A5058646798 @default.
• W304877180 creator A5063064733 @default.
• W304877180 creator A5089109611 @default.
• W304877180 date "1984-06-01" @default.
• W304877180 modified "2023-10-13" @default.
• W304877180 title "Pharmacologic inhibition of thromboxane synthetase and platelet aggregation: modulatory role of cyclooxygenase products" @default.
• W304877180 cites W1572362848 @default.
• W304877180 cites W1896310453 @default.
• W304877180 cites W1963860018 @default.
• W304877180 cites W1964399542 @default.
• W304877180 cites W1970777502 @default.
• W304877180 cites W1974351539 @default.
• W304877180 cites W1978933975 @default.
• W304877180 cites W1987509459 @default.
• W304877180 cites W1989246667 @default.
• W304877180 cites W1992106248 @default.
• W304877180 cites W1993210005 @default.
• W304877180 cites W2024994070 @default.
• W304877180 cites W2038811742 @default.
• W304877180 cites W2039330939 @default.
• W304877180 cites W2051469124 @default.
• W304877180 cites W2053500019 @default.
• W304877180 cites W2059464453 @default.
• W304877180 cites W2063835214 @default.
• W304877180 cites W2076674649 @default.
• W304877180 cites W2079980155 @default.
• W304877180 cites W2080107789 @default.
• W304877180 cites W2083244656 @default.
• W304877180 cites W2083401509 @default.
• W304877180 cites W2084764718 @default.
• W304877180 cites W2097129768 @default.
• W304877180 cites W2119064142 @default.
• W304877180 cites W2155027494 @default.
• W304877180 cites W2463375018 @default.
• W304877180 cites W2474728304 @default.
• W304877180 doi "https://doi.org/10.1182/blood.v63.6.1460.bloodjournal6361460" @default.
• W304877180 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/6426554" @default.
• W304877180 hasPublicationYear "1984" @default.
• W304877180 type Work @default.
• W304877180 sameAs 304877180 @default.
• W304877180 citedByCount "17" @default.
• W304877180 crossrefType "journal-article" @default.
• W304877180 hasAuthorship W304877180A5013871815 @default.
• W304877180 hasAuthorship W304877180A5033092400 @default.
• W304877180 hasAuthorship W304877180A5039927165 @default.
• W304877180 hasAuthorship W304877180A5058646798 @default.
• W304877180 hasAuthorship W304877180A5063064733 @default.
• W304877180 hasAuthorship W304877180A5089109611 @default.
• W304877180 hasBestOaLocation W3048771801 @default.
• W304877180 hasConcept C126322002 @default.
• W304877180 hasConcept C134018914 @default.
• W304877180 hasConcept C173202427 @default.
• W304877180 hasConcept C176685330 @default.
• W304877180 hasConcept C181199279 @default.
• W304877180 hasConcept C185592680 @default.
• W304877180 hasConcept C2776785769 @default.
• W304877180 hasConcept C2777361909 @default.
• W304877180 hasConcept C2778078955 @default.
• W304877180 hasConcept C2779689624 @default.
• W304877180 hasConcept C2780664492 @default.
• W304877180 hasConcept C2781024287 @default.
• W304877180 hasConcept C2781080829 @default.
• W304877180 hasConcept C55493867 @default.
• W304877180 hasConcept C71924100 @default.
• W304877180 hasConcept C86803240 @default.
• W304877180 hasConcept C89560881 @default.
• W304877180 hasConceptScore W304877180C126322002 @default.
• W304877180 hasConceptScore W304877180C134018914 @default.
• W304877180 hasConceptScore W304877180C173202427 @default.
• W304877180 hasConceptScore W304877180C176685330 @default.
• W304877180 hasConceptScore W304877180C181199279 @default.
• W304877180 hasConceptScore W304877180C185592680 @default.
• W304877180 hasConceptScore W304877180C2776785769 @default.
• W304877180 hasConceptScore W304877180C2777361909 @default.
• W304877180 hasConceptScore W304877180C2778078955 @default.
• W304877180 hasConceptScore W304877180C2779689624 @default.
• W304877180 hasConceptScore W304877180C2780664492 @default.
• W304877180 hasConceptScore W304877180C2781024287 @default.
• W304877180 hasConceptScore W304877180C2781080829 @default.
• W304877180 hasConceptScore W304877180C55493867 @default.
• W304877180 hasConceptScore W304877180C71924100 @default.
• W304877180 hasConceptScore W304877180C86803240 @default.
• W304877180 hasConceptScore W304877180C89560881 @default.
• W304877180 hasLocation W3048771801 @default.
• W304877180 hasOpenAccess W304877180 @default.
• W304877180 hasPrimaryLocation W3048771801 @default.
• W304877180 hasRelatedWork W1572362848 @default.
• W304877180 hasRelatedWork W1909721718 @default.
• W304877180 hasRelatedWork W1963860018 @default.
• W304877180 hasRelatedWork W1974351539 @default.
• W304877180 hasRelatedWork W1981159906 @default.
• W304877180 hasRelatedWork W2012214760 @default.
• W304877180 hasRelatedWork W2021403302 @default.
• W304877180 hasRelatedWork W2029344288 @default.
• W304877180 hasRelatedWork W2030087792 @default.

• next