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• W3048772034 abstract "Objective . To investigate the effects of Apatinib on the “stemness” of lung cancer cells in vivo and to explore its related mechanisms. Methods . A xenograft model of lung cancer cells A549 was established in nude mice and randomized into a control group ( n = 4) and an Apatinib group ( n = 4). Tumor tissues were harvested after 2 weeks, and mRNA was extracted to detect changes in stemness-related genes ( CD133 , EPCAM , CD13 , CD90 , ALDH1 , CD44 , CD45 , SOX2 , NANOG , and OCT4 ) and Wnt/ β -catenin, Hedgehog, and Hippo signal pathways. Results . Compared with the control group, the volume and weight of nude mice treated with Apatinib were different and had statistical significance. Apatinib inhibited the expressions of ABCG2 , CD24 , ICAM-1 , OCT4 , and SOX2 and upregulated the expressions of CD44 , CD13 , and FOXD3 . Apatinib treatment also inhibited the Wnt/ β -catenin, Hedgehog, and Hippo signaling pathways. Conclusion . Apatinib suppressed the growth of non-small-cell lung cancer cells by repressing the stemness of lung cancer through the inhibition of the Hedgehog, Hippo, and Wnt signaling pathways." @default.
• W3048772034 created "2020-08-18" @default.
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• W3048772034 date "2020-08-11" @default.
• W3048772034 modified "2023-09-25" @default.
• W3048772034 title "Effects of Apatinib on the “Stemness” of Non-Small-Cell Lung Cancer Cells In Vivo and Its Related Mechanisms" @default.
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• W3048772034 doi "https://doi.org/10.1155/2020/2479369" @default.
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