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- W3048773605 endingPage "317" @default.
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- W3048773605 abstract "Despite major advances in the management and high cure rates of childhood acute lymphoblastic leukemia (ALL), patients still suffer from many drug-induced toxicities, sometimes necessitating dose reduction, or halting of cytotoxic drugs with a secondary risk of disease relapse. In addition, investigators have noted significant inter-individual variability in drug toxicities and disease outcomes, hence the role of pharmacogenetics (PGx) in elucidating genetic polymorphisms in candidate genes for the optimization of disease management. In this review, we present the PGx data in association with main toxicities seen in children treated for ALL in addition to efficacy, with a focus on the most plausible germline PGx variants. We then follow with a summary of the highest evidence drug-gene annotations with suggestions to move forward in implementing preemptive PGx for the individualization of treatment regimens for children with ALL." @default.
- W3048773605 created "2020-08-18" @default.
- W3048773605 creator A5013192671 @default.
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- W3048773605 creator A5051866233 @default.
- W3048773605 creator A5066947022 @default.
- W3048773605 date "2020-08-01" @default.
- W3048773605 modified "2023-10-16" @default.
- W3048773605 title "<p>Implementation of Pharmacogenetics to Individualize Treatment Regimens for Children with Acute Lymphoblastic Leukemia</p>" @default.
- W3048773605 cites W1068268492 @default.
- W3048773605 cites W1269509224 @default.
- W3048773605 cites W1497582288 @default.
- W3048773605 cites W1513910469 @default.
- W3048773605 cites W1534517380 @default.
- W3048773605 cites W1553980985 @default.
- W3048773605 cites W1568449544 @default.
- W3048773605 cites W1666108478 @default.
- W3048773605 cites W1748227957 @default.
- W3048773605 cites W1801979138 @default.
- W3048773605 cites W1872688600 @default.
- W3048773605 cites W1891689427 @default.
- W3048773605 cites W1896195310 @default.
- W3048773605 cites W1932257584 @default.
- W3048773605 cites W1968167771 @default.
- W3048773605 cites W1968553828 @default.
- W3048773605 cites W1969950517 @default.
- W3048773605 cites W1971336136 @default.
- W3048773605 cites W1971579914 @default.
- W3048773605 cites W1979320164 @default.
- W3048773605 cites W1981150611 @default.
- W3048773605 cites W1981424796 @default.
- W3048773605 cites W1982486186 @default.
- W3048773605 cites W1982556402 @default.
- W3048773605 cites W1983654796 @default.
- W3048773605 cites W1990724265 @default.
- W3048773605 cites W1991552974 @default.
- W3048773605 cites W1992391238 @default.
- W3048773605 cites W1993201227 @default.
- W3048773605 cites W1997412038 @default.
- W3048773605 cites W2004640207 @default.
- W3048773605 cites W2005576084 @default.
- W3048773605 cites W2010417259 @default.
- W3048773605 cites W2011669229 @default.
- W3048773605 cites W2012523104 @default.
- W3048773605 cites W2016833582 @default.
- W3048773605 cites W2017613390 @default.
- W3048773605 cites W2023225879 @default.
- W3048773605 cites W2023882066 @default.
- W3048773605 cites W2025581134 @default.
- W3048773605 cites W2030243235 @default.
- W3048773605 cites W2030776792 @default.
- W3048773605 cites W2031824679 @default.
- W3048773605 cites W2036644772 @default.
- W3048773605 cites W2038526706 @default.
- W3048773605 cites W2040730344 @default.
- W3048773605 cites W2044141667 @default.
- W3048773605 cites W2047065011 @default.
- W3048773605 cites W2049968961 @default.
- W3048773605 cites W2050913224 @default.
- W3048773605 cites W2053037274 @default.
- W3048773605 cites W2054474361 @default.
- W3048773605 cites W2056941568 @default.
- W3048773605 cites W2062738339 @default.
- W3048773605 cites W2063280109 @default.
- W3048773605 cites W2064928200 @default.
- W3048773605 cites W2068390769 @default.
- W3048773605 cites W2069546278 @default.
- W3048773605 cites W2072667440 @default.
- W3048773605 cites W2074024827 @default.
- W3048773605 cites W2075744546 @default.
- W3048773605 cites W2077718321 @default.
- W3048773605 cites W2079304065 @default.
- W3048773605 cites W2079378158 @default.
- W3048773605 cites W2079499097 @default.
- W3048773605 cites W2081541637 @default.
- W3048773605 cites W2083260817 @default.
- W3048773605 cites W2083654601 @default.
- W3048773605 cites W2084271415 @default.
- W3048773605 cites W2085038188 @default.
- W3048773605 cites W2085938618 @default.
- W3048773605 cites W2090872748 @default.
- W3048773605 cites W2092314927 @default.
- W3048773605 cites W2093101127 @default.
- W3048773605 cites W2095050768 @default.
- W3048773605 cites W2098738258 @default.
- W3048773605 cites W2099204763 @default.
- W3048773605 cites W2099729170 @default.
- W3048773605 cites W2104302257 @default.
- W3048773605 cites W2104737185 @default.
- W3048773605 cites W2104813838 @default.
- W3048773605 cites W2108636446 @default.
- W3048773605 cites W2109000403 @default.
- W3048773605 cites W2109133025 @default.
- W3048773605 cites W2111621946 @default.
- W3048773605 cites W2117657336 @default.
- W3048773605 cites W2120071742 @default.
- W3048773605 cites W2122151991 @default.