FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3048777112> ?p ?o ?g. }

• W3048777112 endingPage "5795" @default.
• W3048777112 startingPage "5795" @default.
• W3048777112 abstract "Focal adhesion kinase (FAK) is over-expressed and is correlated with aggressiveness in adult hepatocellular carcinoma (HCC). Inhibition of FAK decreases HCC invasiveness by down-regulating Enhancer of Zeste homolog 2 (EZH2), an epigenetic controller, that acts in transcriptional repression of a large number of genes via histone 3 methylation of lysine 27 (H3K27me3). Here, we investigated the hepatic expression of total FAK, EZH2, H3K27me3, and proliferating cell nuclear antigen (PCNA) in 17 pediatric HCCs and 8 healthy livers (CTRL). Quantitative imaging analysis showed that FAK gene/protein expression is up-regulated in HCCs compared to CTRL and, among tumor samples the levels of this gene/protein are significantly higher in cirrhotic HCCs than in a healthy milieu. Accordingly, the protein levels of EZH2 were also significantly increased in HCCs from a cirrhotic background. Intriguingly, the protein expression of FAK, EZH2, and PCNA significantly inversely correlated with tumor size. Finally, in HCC samples, mainly in cirrhotic background, the up-regulation of FAK gene positively correlated with that observed in β-Catenin gene. Conclusion: FAK gene/protein is over-expressed in pediatric HCCs concomitantly to EZH2 protein and β-Catenin gene, with a more significant up-regulation in a cirrhotic background. This triad of interactors deserves further investigations for translational application." @default.
• W3048777112 created "2020-08-18" @default.
• W3048777112 creator A5002406453 @default.
• W3048777112 creator A5005655854 @default.
• W3048777112 creator A5009197038 @default.
• W3048777112 creator A5010731493 @default.
• W3048777112 creator A5015423699 @default.
• W3048777112 creator A5044647271 @default.
• W3048777112 creator A5057294490 @default.
• W3048777112 creator A5061728147 @default.
• W3048777112 creator A5079285966 @default.
• W3048777112 date "2020-08-12" @default.
• W3048777112 modified "2023-10-10" @default.
• W3048777112 title "Focal Adhesion Kinase (FAK) Over-Expression and Prognostic Implication in Pediatric Hepatocellular Carcinoma" @default.
• W3048777112 cites W1532057395 @default.
• W3048777112 cites W1986418310 @default.
• W3048777112 cites W1987822177 @default.
• W3048777112 cites W2010124836 @default.
• W3048777112 cites W2012028536 @default.
• W3048777112 cites W2015346703 @default.
• W3048777112 cites W2050419281 @default.
• W3048777112 cites W2105154348 @default.
• W3048777112 cites W2150093422 @default.
• W3048777112 cites W2152376049 @default.
• W3048777112 cites W2164241627 @default.
• W3048777112 cites W2171925512 @default.
• W3048777112 cites W2313938789 @default.
• W3048777112 cites W2568898976 @default.
• W3048777112 cites W2598927934 @default.
• W3048777112 cites W2625617042 @default.
• W3048777112 cites W2888189085 @default.
• W3048777112 cites W2890096661 @default.
• W3048777112 cites W2892597439 @default.
• W3048777112 cites W2937659512 @default.
• W3048777112 cites W2943991880 @default.
• W3048777112 cites W2949922878 @default.
• W3048777112 cites W2972416518 @default.
• W3048777112 cites W44365434 @default.
• W3048777112 doi "https://doi.org/10.3390/ijms21165795" @default.
• W3048777112 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7460809" @default.
• W3048777112 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32806748" @default.
• W3048777112 hasPublicationYear "2020" @default.
• W3048777112 type Work @default.
• W3048777112 sameAs 3048777112 @default.
• W3048777112 citedByCount "12" @default.
• W3048777112 countsByYear W30487771122020 @default.
• W3048777112 countsByYear W30487771122021 @default.
• W3048777112 countsByYear W30487771122022 @default.
• W3048777112 countsByYear W30487771122023 @default.
• W3048777112 crossrefType "journal-article" @default.
• W3048777112 hasAuthorship W3048777112A5002406453 @default.
• W3048777112 hasAuthorship W3048777112A5005655854 @default.
• W3048777112 hasAuthorship W3048777112A5009197038 @default.
• W3048777112 hasAuthorship W3048777112A5010731493 @default.
• W3048777112 hasAuthorship W3048777112A5015423699 @default.
• W3048777112 hasAuthorship W3048777112A5044647271 @default.
• W3048777112 hasAuthorship W3048777112A5057294490 @default.
• W3048777112 hasAuthorship W3048777112A5061728147 @default.
• W3048777112 hasAuthorship W3048777112A5079285966 @default.
• W3048777112 hasBestOaLocation W30487771121 @default.
• W3048777112 hasConcept C104317684 @default.
• W3048777112 hasConcept C150194340 @default.
• W3048777112 hasConcept C151166631 @default.
• W3048777112 hasConcept C153911025 @default.
• W3048777112 hasConcept C165864922 @default.
• W3048777112 hasConcept C2778019345 @default.
• W3048777112 hasConcept C2779314089 @default.
• W3048777112 hasConcept C34688535 @default.
• W3048777112 hasConcept C41091548 @default.
• W3048777112 hasConcept C50171091 @default.
• W3048777112 hasConcept C502942594 @default.
• W3048777112 hasConcept C54355233 @default.
• W3048777112 hasConcept C62112901 @default.
• W3048777112 hasConcept C62478195 @default.
• W3048777112 hasConcept C64927066 @default.
• W3048777112 hasConcept C86803240 @default.
• W3048777112 hasConcept C95444343 @default.
• W3048777112 hasConceptScore W3048777112C104317684 @default.
• W3048777112 hasConceptScore W3048777112C150194340 @default.
• W3048777112 hasConceptScore W3048777112C151166631 @default.
• W3048777112 hasConceptScore W3048777112C153911025 @default.
• W3048777112 hasConceptScore W3048777112C165864922 @default.
• W3048777112 hasConceptScore W3048777112C2778019345 @default.
• W3048777112 hasConceptScore W3048777112C2779314089 @default.
• W3048777112 hasConceptScore W3048777112C34688535 @default.
• W3048777112 hasConceptScore W3048777112C41091548 @default.
• W3048777112 hasConceptScore W3048777112C50171091 @default.
• W3048777112 hasConceptScore W3048777112C502942594 @default.
• W3048777112 hasConceptScore W3048777112C54355233 @default.
• W3048777112 hasConceptScore W3048777112C62112901 @default.
• W3048777112 hasConceptScore W3048777112C62478195 @default.
• W3048777112 hasConceptScore W3048777112C64927066 @default.
• W3048777112 hasConceptScore W3048777112C86803240 @default.
• W3048777112 hasConceptScore W3048777112C95444343 @default.
• W3048777112 hasFunder F4320323054 @default.
• W3048777112 hasIssue "16" @default.
• W3048777112 hasLocation W30487771121 @default.
• W3048777112 hasLocation W30487771122 @default.

• next