FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3048777786> ?p ?o ?g. }

• W3048777786 endingPage "5304" @default.
• W3048777786 startingPage "5290" @default.
• W3048777786 abstract "Certain nanosized particles like carbon nanotubes (CNTs) are known to induce pulmonary fibrosis, but the underlying mechanisms are unclear, and efforts to prevent this disease are lacking. Fibroblast-associated stem cells (FSCs) have been suggested as a critical driver of fibrosis induced by CNTs by serving as a renewable source of extracellular matrix-producing cells; however, a detailed understanding of this process remains obscure. Here, we demonstrated that single-walled CNTs induced FSC acquisition and fibrogenic responses in primary human lung fibroblasts. This was indicated by increased expression of stem cell markers (e.g., CD44 and ABCG2) and fibrogenic markers (e.g., collagen and α-SMA) in CNT-exposed cells. These cells also showed increased sphere formation, anoikis resistance, and aldehyde dehydrogenase (ALDH) activities, which are characteristics of stem cells. Mechanistic studies revealed sex-determining region Y-box 2 (SOX2), a self-renewal associated transcription factor, as a key driver of FSC acquisition and fibrogenesis. Upregulation and colocalization of SOX2 and COL1 were found in the fibrotic lung tissues of CNT-exposed mice via oropharyngeal aspiration after 56 days. The knockdown of SOX2 by gene silencing abrogated the fibrogenic and FSC-inducing effects of CNTs. Chromatin immunoprecipitation assays identified SOX2-binding sites on COL1A1 and COL1A2, indicating SOX2 as a transcription factor in collagen synthesis. SOX2 was also found to play a critical role in TGF-β-induced fibrogenesis through its collagen- and FSC-inducing effects. Since many nanomaterials are known to induce TGF-β, our findings that SOX2 regulate FSCs and fibrogenesis may have broad implications on the fibrogenic mechanisms and treatment strategies of various nanomaterial-induced fibrotic disorders." @default.
• W3048777786 created "2020-08-18" @default.
• W3048777786 creator A5033216187 @default.
• W3048777786 creator A5035419345 @default.
• W3048777786 creator A5035799232 @default.
• W3048777786 creator A5038779886 @default.
• W3048777786 creator A5041249304 @default.
• W3048777786 creator A5071360626 @default.
• W3048777786 creator A5080894648 @default.
• W3048777786 date "2020-08-11" @default.
• W3048777786 modified "2023-09-23" @default.
• W3048777786 title "SOX2Mediates Carbon Nanotube-Induced Fibrogenesis and Fibroblast Stem Cell Acquisition" @default.
• W3048777786 cites W1523926115 @default.
• W3048777786 cites W1905645718 @default.
• W3048777786 cites W1964237645 @default.
• W3048777786 cites W1995297665 @default.
• W3048777786 cites W2001622142 @default.
• W3048777786 cites W2005196931 @default.
• W3048777786 cites W2019883183 @default.
• W3048777786 cites W2020633796 @default.
• W3048777786 cites W2024729494 @default.
• W3048777786 cites W2064805149 @default.
• W3048777786 cites W2069608579 @default.
• W3048777786 cites W2082559993 @default.
• W3048777786 cites W2094498700 @default.
• W3048777786 cites W2095443864 @default.
• W3048777786 cites W2101011425 @default.
• W3048777786 cites W2108035852 @default.
• W3048777786 cites W2117192811 @default.
• W3048777786 cites W2124283853 @default.
• W3048777786 cites W2128976939 @default.
• W3048777786 cites W2130406156 @default.
• W3048777786 cites W2133937363 @default.
• W3048777786 cites W2137766969 @default.
• W3048777786 cites W2142500586 @default.
• W3048777786 cites W2146565869 @default.
• W3048777786 cites W2147632322 @default.
• W3048777786 cites W2150664328 @default.
• W3048777786 cites W2151609134 @default.
• W3048777786 cites W2152186584 @default.
• W3048777786 cites W2160275284 @default.
• W3048777786 cites W2160649991 @default.
• W3048777786 cites W2166278470 @default.
• W3048777786 cites W2171741011 @default.
• W3048777786 cites W2217682835 @default.
• W3048777786 cites W2273637189 @default.
• W3048777786 cites W2292742428 @default.
• W3048777786 cites W2315446568 @default.
• W3048777786 cites W2323231500 @default.
• W3048777786 cites W2400138616 @default.
• W3048777786 cites W2416046723 @default.
• W3048777786 cites W2463738079 @default.
• W3048777786 cites W2488777145 @default.
• W3048777786 cites W2497192058 @default.
• W3048777786 cites W2510409530 @default.
• W3048777786 cites W2531760406 @default.
• W3048777786 cites W2598727520 @default.
• W3048777786 cites W2609825451 @default.
• W3048777786 cites W2623543676 @default.
• W3048777786 cites W2736102792 @default.
• W3048777786 cites W2742637229 @default.
• W3048777786 cites W2743476964 @default.
• W3048777786 cites W2751220340 @default.
• W3048777786 cites W2768011966 @default.
• W3048777786 cites W2777389776 @default.
• W3048777786 cites W2782417153 @default.
• W3048777786 cites W2789175950 @default.
• W3048777786 cites W2794148061 @default.
• W3048777786 cites W2794423958 @default.
• W3048777786 cites W2802419311 @default.
• W3048777786 cites W2807334294 @default.
• W3048777786 cites W2886904368 @default.
• W3048777786 cites W2891481486 @default.
• W3048777786 cites W2903199417 @default.
• W3048777786 cites W2903561922 @default.
• W3048777786 cites W2909429444 @default.
• W3048777786 cites W2946159232 @default.
• W3048777786 cites W2985676661 @default.
• W3048777786 doi "https://doi.org/10.1021/acsbiomaterials.0c00887" @default.
• W3048777786 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8215839" @default.
• W3048777786 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33455278" @default.
• W3048777786 hasPublicationYear "2020" @default.
• W3048777786 type Work @default.
• W3048777786 sameAs 3048777786 @default.
• W3048777786 citedByCount "4" @default.
• W3048777786 countsByYear W30487777862022 @default.
• W3048777786 countsByYear W30487777862023 @default.
• W3048777786 crossrefType "journal-article" @default.
• W3048777786 hasAuthorship W3048777786A5033216187 @default.
• W3048777786 hasAuthorship W3048777786A5035419345 @default.
• W3048777786 hasAuthorship W3048777786A5035799232 @default.
• W3048777786 hasAuthorship W3048777786A5038779886 @default.
• W3048777786 hasAuthorship W3048777786A5041249304 @default.
• W3048777786 hasAuthorship W3048777786A5071360626 @default.
• W3048777786 hasAuthorship W3048777786A5080894648 @default.
• W3048777786 hasBestOaLocation W30487777862 @default.
• W3048777786 hasConcept C104317684 @default.
• W3048777786 hasConcept C142724271 @default.

• next