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• W3048783304 abstract "ABSTRACT The adapted industrial yeast strain Saccharomyces cerevisiae NRRL Y-50049 is able to in situ detoxify major toxic aldehyde compounds derived from sugar conversion of lignocellulosic biomass while producing ethanol. Pathway-based studies on its mechanisms of tolerance have been reported previously, however, little is known about transposable element (TE) involvement in its adaptation to inhibitory compounds. This work presents a comparative dynamic transcription expression analysis in response to a toxic treatment between Y-50049 and its progenitor, an industrial type strain NRRL Y-12632, using a time-course study. At least 77 TEs from Y-50049 showed significantly increased expression compared with its progenitor, especially during the late lag phase. Sequence analysis revealed significant differences in TE sequences between the two strains. Y-50049 was also found to have a transposons of yeast 2 (Ty2) long terminal repeat-linked YAT1 gene showing significantly higher copy number changes than its progenitor. These results raise awareness of potential TE involvement in the adaptation of industrial yeast to the tolerance of toxic chemicals." @default.
• W3048783304 created "2020-08-18" @default.
• W3048783304 creator A5022987905 @default.
• W3048783304 creator A5073642358 @default.
• W3048783304 date "2020-08-11" @default.
• W3048783304 modified "2023-09-26" @default.
• W3048783304 title "A glimpse of potential transposable element impact on adaptation of the industrial yeast <i>Saccharomyces cerevisiae</i>" @default.
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• W3048783304 doi "https://doi.org/10.1093/femsyr/foaa043" @default.
• W3048783304 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32780789" @default.
• W3048783304 hasPublicationYear "2020" @default.
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