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• W3048790590 startingPage "1361" @default.
• W3048790590 abstract "Abstract Chromosomal abnormalities are frequently observed in patients with chronic lymphocytic leukemia (CLL) and have prognostic value. Deletions of the short arm of chromosome 17 (and/or mutations TP53 ) predict resistance to chemoimmunotherapy and shorter progression‐free survival after targeted therapies. Although the complex karyotype (CK) is strongly predictive of a poor prognosis in hematologic malignancies such acute myeloid leukemia or myelodysplastic syndrome, its value in CLL is subject to debate. Here, we review the literature on the CK in CLL and examine its prognostic value with different treatments. We also propose a standardized method for defining a CK in all types of hematopoietic neoplasm." @default.
• W3048790590 created "2020-08-18" @default.
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• W3048790590 date "2020-08-28" @default.
• W3048790590 modified "2023-10-18" @default.
• W3048790590 title "The complex karyotype and chronic lymphocytic leukemia: prognostic value and diagnostic recommendations" @default.
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• W3048790590 doi "https://doi.org/10.1002/ajh.25956" @default.
• W3048790590 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32777106" @default.
• W3048790590 hasPublicationYear "2020" @default.
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