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• W3048791055 endingPage "2579" @default.
• W3048791055 startingPage "2569" @default.
• W3048791055 abstract "The aim of the present study was to identify key microRNAs (miRNAs) in porcine follicular fluid (FF) that regulate oocyte growth. miRNAs contained in FF were determined by small RNA-seq of exosome RNA. Upstream regulator miRNA was determined by ingenuity pathway analysis using differentially expressed genes in granulosa cells (GCs) between small follicles (1–2 mm in diameter) and large follicles (3–5 mm), and between follicles containing oocytes of high developmental ability and follicles containing oocytes of low developmental ability. The candidate miRNAs overlapping among the three miRNAs group were determined. Lastly, the effect of supplementation with FF, exosome-depleted FFs, or each miRNA on in vitro oocyte growth was examined. The miRNAs determined were miR-17, -27, -92a, and -145. These miRNAs were found in the spent culture medium of oocytes and granulosa cells complexes and serum by small RNA sequencing. Culturing of oocytes and granulosa cells complexes collected from porcine early antral follicles (0.5–0.7 mm in diameter) with FF for 14 days improved oocyte growth; depletion of exosomes from the FFs neutralized the beneficial effect observed. miR-92a mimic increased the antrum formation and diameter, together with acetylated levels of H4K12 in oocytes. In addition, supplementation of miRNA mimics miR-17b, -92a, and -145b improved the rate of chromatin configuration, and miR-17b and -92a mimics improved the developmental ability of oocytes to the blastocyst stage. miR-17, -92a, and -145 are major miRNA candidates in follicular fluids regulating oocyte growth." @default.
• W3048791055 created "2020-08-18" @default.
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• W3048791055 date "2020-08-11" @default.
• W3048791055 modified "2023-10-02" @default.
• W3048791055 title "Prediction of major microRNAs in follicular fluid regulating porcine oocyte development" @default.
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• W3048791055 doi "https://doi.org/10.1007/s10815-020-01909-0" @default.
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• W3048791055 hasPublicationYear "2020" @default.
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