Matches in SemOpenAlex for { <https://semopenalex.org/work/W3048793083> ?p ?o ?g. }
- W3048793083 abstract "Chimeric Antigen Receptor (CAR) T cell therapy has recently begun to be used for solid tumors such as glioblastoma multiforme. Many children with pediatric malignant brain tumors develop extensive long-term morbidity of intensive multimodal curative treatment. Others with certain diagnoses and relapsed disease continue to have limited therapies and a dismal prognosis. Novel treatments such as CAR T cells could potentially improve outcomes and ameliorate the toxicity of current treatment. In this review, we discuss the potential of using CAR therapy for pediatric brain tumors. The emerging insights on the molecular subtypes and tumor microenvironment of these tumors provide avenues to devise strategies for CAR T cell therapy. Unique characteristics of these brain tumors, such as location and associated morbid treatment induced neuro-inflammation, are novel challenges not commonly encountered in adult brain tumors. Despite these considerations, CAR T cell therapy has the potential to be integrated into treatment schema for aggressive pediatric malignant brain tumors in the future." @default.
- W3048793083 created "2020-08-18" @default.
- W3048793083 creator A5000749732 @default.
- W3048793083 creator A5002257911 @default.
- W3048793083 creator A5026935020 @default.
- W3048793083 creator A5039715134 @default.
- W3048793083 creator A5064277553 @default.
- W3048793083 date "2020-08-12" @default.
- W3048793083 modified "2023-10-16" @default.
- W3048793083 title "CAR T Cell Therapy for Pediatric Brain Tumors" @default.
- W3048793083 cites W142203824 @default.
- W3048793083 cites W1560675913 @default.
- W3048793083 cites W1573309974 @default.
- W3048793083 cites W1574443686 @default.
- W3048793083 cites W1585147201 @default.
- W3048793083 cites W1604141497 @default.
- W3048793083 cites W1607620597 @default.
- W3048793083 cites W1619537825 @default.
- W3048793083 cites W1880621477 @default.
- W3048793083 cites W1909245362 @default.
- W3048793083 cites W1949037014 @default.
- W3048793083 cites W1965522214 @default.
- W3048793083 cites W1974223809 @default.
- W3048793083 cites W1979321534 @default.
- W3048793083 cites W1979685702 @default.
- W3048793083 cites W1983906797 @default.
- W3048793083 cites W1985579610 @default.
- W3048793083 cites W1987790028 @default.
- W3048793083 cites W1995338672 @default.
- W3048793083 cites W2003422441 @default.
- W3048793083 cites W2007753376 @default.
- W3048793083 cites W2009483826 @default.
- W3048793083 cites W2012034410 @default.
- W3048793083 cites W2012828884 @default.
- W3048793083 cites W2017308570 @default.
- W3048793083 cites W2021465889 @default.
- W3048793083 cites W2024020239 @default.
- W3048793083 cites W2027446300 @default.
- W3048793083 cites W2027729143 @default.
- W3048793083 cites W2028460943 @default.
- W3048793083 cites W2028643362 @default.
- W3048793083 cites W2030393556 @default.
- W3048793083 cites W2032803186 @default.
- W3048793083 cites W2033909439 @default.
- W3048793083 cites W2036970197 @default.
- W3048793083 cites W2040458067 @default.
- W3048793083 cites W2040773741 @default.
- W3048793083 cites W2043301967 @default.
- W3048793083 cites W2047205338 @default.
- W3048793083 cites W2048546023 @default.
- W3048793083 cites W2048896826 @default.
- W3048793083 cites W2050111353 @default.
- W3048793083 cites W2050785743 @default.
- W3048793083 cites W2052279202 @default.
- W3048793083 cites W2056040684 @default.
- W3048793083 cites W2062062519 @default.
- W3048793083 cites W2064510700 @default.
- W3048793083 cites W2069860553 @default.
- W3048793083 cites W2076560655 @default.
- W3048793083 cites W2079146850 @default.
- W3048793083 cites W2087055812 @default.
- W3048793083 cites W2089933204 @default.
- W3048793083 cites W2090244008 @default.
- W3048793083 cites W2096389376 @default.
- W3048793083 cites W2100158834 @default.
- W3048793083 cites W2102569784 @default.
- W3048793083 cites W2104348780 @default.
- W3048793083 cites W2105400883 @default.
- W3048793083 cites W2107280222 @default.
- W3048793083 cites W2107484016 @default.
- W3048793083 cites W2110172571 @default.
- W3048793083 cites W2111137187 @default.
- W3048793083 cites W2113249787 @default.
- W3048793083 cites W2114551767 @default.
- W3048793083 cites W2115159844 @default.
- W3048793083 cites W2116365316 @default.
- W3048793083 cites W2117482566 @default.
- W3048793083 cites W2118097751 @default.
- W3048793083 cites W2118124054 @default.
- W3048793083 cites W2120672212 @default.
- W3048793083 cites W2121047359 @default.
- W3048793083 cites W2121934915 @default.
- W3048793083 cites W2124408488 @default.
- W3048793083 cites W2126709464 @default.
- W3048793083 cites W2126738508 @default.
- W3048793083 cites W2127643721 @default.
- W3048793083 cites W2129331946 @default.
- W3048793083 cites W2129504986 @default.
- W3048793083 cites W2130393835 @default.
- W3048793083 cites W2130737806 @default.
- W3048793083 cites W2136849863 @default.
- W3048793083 cites W2137405984 @default.
- W3048793083 cites W2138541072 @default.
- W3048793083 cites W2140048538 @default.
- W3048793083 cites W2140266186 @default.
- W3048793083 cites W2141541918 @default.
- W3048793083 cites W2144143639 @default.
- W3048793083 cites W2145489645 @default.
- W3048793083 cites W2145755261 @default.
- W3048793083 cites W2150794759 @default.