Matches in SemOpenAlex for { <https://semopenalex.org/work/W3048797344> ?p ?o ?g. }
- W3048797344 endingPage "1186" @default.
- W3048797344 startingPage "1177" @default.
- W3048797344 abstract "Psoriasis is a chronic inflammatory disorder with cutaneous and systemic manifestations and substantial negative effects on patients' quality of life. MicroRNAs (miRNAs) are post-transcriptional regulators of gene expression that play a role in the pathogenesis of psoriasis. Previously studies, from others and by us, highlighted specific miRNAs that are dysregulated in psoriatic lesions. MicroRNA-197-3p (miR-197) expression is downregulated in psoriatic lesions compared to normal or uninvolved skin in patients with psoriasis. We have previously reported that miR-197 could modulate IL-22 and IL-17 signalling in psoriasis. Herein, we identify additional biochemical targets of miR-197 in psoriasis. We applied a transcriptome-wide biochemical approach, Protein argonaute-2 photoactivatable ribonucleoside-enhanced crosslinking and immunoprecipitation (Ago2 PAR-CLIP), to search for new targets of miR-197 in live keratinocytes, and validated its results using reporter assay and analysing by Western blot protein levels in cells overexpressing miR-197. Ago2 PAR-CLIP identified biochemical targets of miR-197, including the alpha subunit of the IL-6 receptor (IL6R). This work provides evidence that IL6R in bona-fide biochemical target of miR-197. IL6R is known to be up-regulated in psoriasis and even was considered as a possible therapeutic target. From the present data and our previous studies, it appears that miR-197 is a major regulator of the interaction between immune system cells and keratinocytes." @default.
- W3048797344 created "2020-08-18" @default.
- W3048797344 creator A5010087158 @default.
- W3048797344 creator A5020843120 @default.
- W3048797344 creator A5038698602 @default.
- W3048797344 creator A5072023589 @default.
- W3048797344 creator A5075354766 @default.
- W3048797344 creator A5082949175 @default.
- W3048797344 creator A5086787074 @default.
- W3048797344 date "2020-09-21" @default.
- W3048797344 modified "2023-10-18" @default.
- W3048797344 title "<i>IL6R</i> is a target of miR‐197 in human keratinocytes" @default.
- W3048797344 cites W1531953029 @default.
- W3048797344 cites W1563810104 @default.
- W3048797344 cites W1807061368 @default.
- W3048797344 cites W1880491945 @default.
- W3048797344 cites W1933410688 @default.
- W3048797344 cites W1967376453 @default.
- W3048797344 cites W1967597978 @default.
- W3048797344 cites W1978784392 @default.
- W3048797344 cites W1983224547 @default.
- W3048797344 cites W1989001888 @default.
- W3048797344 cites W1991320836 @default.
- W3048797344 cites W1991544505 @default.
- W3048797344 cites W1996548067 @default.
- W3048797344 cites W1999821753 @default.
- W3048797344 cites W2012468371 @default.
- W3048797344 cites W2015733769 @default.
- W3048797344 cites W2017223857 @default.
- W3048797344 cites W2017426710 @default.
- W3048797344 cites W2017607160 @default.
- W3048797344 cites W2045685910 @default.
- W3048797344 cites W2045934824 @default.
- W3048797344 cites W2047516222 @default.
- W3048797344 cites W2053003053 @default.
- W3048797344 cites W2060026998 @default.
- W3048797344 cites W2066533513 @default.
- W3048797344 cites W2070940808 @default.
- W3048797344 cites W2072943471 @default.
- W3048797344 cites W2075860675 @default.
- W3048797344 cites W2092018614 @default.
- W3048797344 cites W2093223136 @default.
- W3048797344 cites W2094655396 @default.
- W3048797344 cites W2097147259 @default.
- W3048797344 cites W2097438318 @default.
- W3048797344 cites W2104806799 @default.
- W3048797344 cites W2108234281 @default.
- W3048797344 cites W2117092553 @default.
- W3048797344 cites W2129216514 @default.
- W3048797344 cites W2132888671 @default.
- W3048797344 cites W2139443896 @default.
- W3048797344 cites W2140578869 @default.
- W3048797344 cites W2141549067 @default.
- W3048797344 cites W2143464311 @default.
- W3048797344 cites W2144831969 @default.
- W3048797344 cites W2145021085 @default.
- W3048797344 cites W2149130539 @default.
- W3048797344 cites W2149358418 @default.
- W3048797344 cites W2149935143 @default.
- W3048797344 cites W2155376306 @default.
- W3048797344 cites W2159793493 @default.
- W3048797344 cites W2162098634 @default.
- W3048797344 cites W2165697838 @default.
- W3048797344 cites W2252831342 @default.
- W3048797344 cites W2430917629 @default.
- W3048797344 cites W2440841988 @default.
- W3048797344 cites W2539087954 @default.
- W3048797344 cites W2558670479 @default.
- W3048797344 cites W2589406797 @default.
- W3048797344 cites W2600421865 @default.
- W3048797344 cites W2754920641 @default.
- W3048797344 cites W2789246335 @default.
- W3048797344 cites W2805726226 @default.
- W3048797344 cites W2890743238 @default.
- W3048797344 cites W4211064852 @default.
- W3048797344 cites W4211202219 @default.
- W3048797344 doi "https://doi.org/10.1111/exd.14169" @default.
- W3048797344 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32780449" @default.
- W3048797344 hasPublicationYear "2020" @default.
- W3048797344 type Work @default.
- W3048797344 sameAs 3048797344 @default.
- W3048797344 citedByCount "5" @default.
- W3048797344 countsByYear W30487973442021 @default.
- W3048797344 countsByYear W30487973442022 @default.
- W3048797344 countsByYear W30487973442023 @default.
- W3048797344 crossrefType "journal-article" @default.
- W3048797344 hasAuthorship W3048797344A5010087158 @default.
- W3048797344 hasAuthorship W3048797344A5020843120 @default.
- W3048797344 hasAuthorship W3048797344A5038698602 @default.
- W3048797344 hasAuthorship W3048797344A5072023589 @default.
- W3048797344 hasAuthorship W3048797344A5075354766 @default.
- W3048797344 hasAuthorship W3048797344A5082949175 @default.
- W3048797344 hasAuthorship W3048797344A5086787074 @default.
- W3048797344 hasConcept C104317684 @default.
- W3048797344 hasConcept C145059251 @default.
- W3048797344 hasConcept C150194340 @default.
- W3048797344 hasConcept C162317418 @default.
- W3048797344 hasConcept C203014093 @default.