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- W3048797426 abstract "Tuberculosis continues to kill millions of people each year. The main difficulty in eradication of the disease is the prolonged duration of treatment, which takes at least 6 months. Persister cells have long been associated with failed treatment and disease relapse because of their phenotypical, though transient, tolerance to drugs. By targeting these persisters, the duration of treatment could be shortened, leading to improved tuberculosis treatment and a reduction in transmission. The unique in vivo environment drives the generation of persisters; however, appropriate in vivo mycobacterial persister models enabling optimized drug screening are lacking." @default.
- W3048797426 created "2020-08-18" @default.
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- W3048797426 date "2020-09-21" @default.
- W3048797426 modified "2023-09-29" @default.
- W3048797426 title "Zebrafish Embryo Model for Assessment of Drug Efficacy on Mycobacterial Persisters" @default.
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- W3048797426 doi "https://doi.org/10.1128/aac.00801-20" @default.
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