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- W3048809627 endingPage "16" @default.
- W3048809627 startingPage "1" @default.
- W3048809627 abstract "PPARs are ligand-activated transcriptional factors that belong to the nuclear receptor superfamily. Among them, PPAR alpha and PPAR gamma are prone to exert an antiangiogenic effect, whereas PPAR beta/delta has an opposite effect in physiological and pathological conditions. Angiogenesis has been known as a hallmark of cancer, and our recent works also demonstrate that vascular-specific PPAR beta/delta overexpression promotes tumor angiogenesis and progression in vivo. In this review, we will mainly focus on the role of PPAR beta/delta in tumor angiogenesis linked to the tumor microenvironment to further facilitate tumor progression and metastasis. Moreover, the crosstalk between PPAR beta/delta and its downstream key signal molecules involved in tumor angiogenesis will also be discussed, and the network of interplay between them will further be established in the review." @default.
- W3048809627 created "2020-08-18" @default.
- W3048809627 creator A5010230635 @default.
- W3048809627 creator A5069245717 @default.
- W3048809627 creator A5073673633 @default.
- W3048809627 date "2020-08-13" @default.
- W3048809627 modified "2023-10-18" @default.
- W3048809627 title "The Emerging Role of PPAR Beta/Delta in Tumor Angiogenesis" @default.
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