FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3048844710> ?p ?o ?g. }

• W3048844710 endingPage "151" @default.
• W3048844710 startingPage "149" @default.
• W3048844710 abstract "In this issue of Cell Host & Microbe, Adebayo et al., 2020Adebayo A.S. Ackermann G. Bowyer R.C.E. Wells P.M. Humphreys G. Knight R. Spector T.D. Steves C.J. The urinary tract microbiome in older women exhibits host genetic and environmental influences.Cell Host Microbe. 2020; 28 (this issue): 298-305Abstract Full Text Full Text PDF PubMed Scopus (20) Google Scholar examine the urobiome of older community-dwelling women within the TwinUK Cohort. They define a core genitourinary microbiome for older women with many heritable microbial taxa. Some taxa appear to co-occur, suggesting the existence of specific microbial consortia. In this issue of Cell Host & Microbe, Adebayo et al., 2020Adebayo A.S. Ackermann G. Bowyer R.C.E. Wells P.M. Humphreys G. Knight R. Spector T.D. Steves C.J. The urinary tract microbiome in older women exhibits host genetic and environmental influences.Cell Host Microbe. 2020; 28 (this issue): 298-305Abstract Full Text Full Text PDF PubMed Scopus (20) Google Scholar examine the urobiome of older community-dwelling women within the TwinUK Cohort. They define a core genitourinary microbiome for older women with many heritable microbial taxa. Some taxa appear to co-occur, suggesting the existence of specific microbial consortia. In less than a decade, urinary microbiome (urobiome) research has replaced the incorrect “bladder is sterile” dogma with clear evidence that healthy adults have a resident microbial community in their lower urinary tract (Mueller et al., 2017Mueller E.R. Wolfe A.J. Brubaker L. Female urinary microbiota.Curr. Opin. Urol. 2017; 27: 282-286Crossref PubMed Scopus (42) Google Scholar; Thomas-White et al., 2016Thomas-White K. Brady M. Wolfe A.J. Mueller E.R. The bladder is not sterile: History and current discoveries on the urinary microbiome.Curr. Bladder Dysfunct. Rep. 2016; 11: 18-24Crossref PubMed Scopus (80) Google Scholar). In this issue, Adebayo and colleagues contribute their findings from a large-scale cohort analysis of midstream voided urine samples obtained from 1,600 adult women without urinary tract infections (UTIs) who were participants in the TwinsUK cohort (Adebayo et al., 2020Adebayo A.S. Ackermann G. Bowyer R.C.E. Wells P.M. Humphreys G. Knight R. Spector T.D. Steves C.J. The urinary tract microbiome in older women exhibits host genetic and environmental influences.Cell Host Microbe. 2020; 28 (this issue): 298-305Abstract Full Text Full Text PDF PubMed Scopus (20) Google Scholar), which includes thousands of monozygotic (identical) and dizygotic (non-identical) twins (Verdi et al., 2019Verdi S. Abbasian G. Bowyer R.C.E. Lachance G. Yarand D. Christofidou P. Mangino M. Menni C. Bell J.T. Falchi M. et al.TwinsUK: The UK Adult Twin Registry Update.Twin Res. Hum. Genet. 2019; 22: 523-529Crossref PubMed Scopus (57) Google Scholar). This analysis used differences between monozygotic and dizygotic twins to explore host factors associated with the microbiome of midstream voided urine. Compared to the well-studied gut microbiome, the urobiome has a much lower biomass, making it exquisitely susceptible to contamination. Furthermore, the sample collection method impacts interpretation of urobiome data. An early urobiome study of adult women compared the microbiomes of urine samples obtained by transurethral catheter to those obtained by suprapubic aspirate (a needle through the lower abdomen directly into the bladder). Transurethral catheterization closely approximated the sample obtained by suprapubic aspiration, which bypasses vulvovaginal contamination (Wolfe et al., 2012Wolfe A.J. Toh E. Shibata N. Rong R. Kenton K. Fitzgerald M. Mueller E.R. Schreckenberger P. Dong Q. Nelson D.E. Brubaker L. Evidence of uncultivated bacteria in the adult female bladder.J. Clin. Microbiol. 2012; 50: 1376-1383Crossref PubMed Scopus (334) Google Scholar), and thus much foundational urobiome research used catheterized urine (Thomas-White et al., 2016Thomas-White K. Brady M. Wolfe A.J. Mueller E.R. The bladder is not sterile: History and current discoveries on the urinary microbiome.Curr. Bladder Dysfunct. Rep. 2016; 11: 18-24Crossref PubMed Scopus (80) Google Scholar). However, catheterization limits applicability in population-based studies. Thus, most urine samples for clinical purposes are collected using the so-called “clean catch” method with the intent to collect a midstream voided urine sample. However, these samples quite often contain post-urethral microbes, especially in older women, and are best interpreted as genitourinary samples as opposed to bladder or even lower urinary tract samples. This study by Adebayo and colleagues helps characterize the genitourinary microbiome of asymptomatic older adult women and identifies the host factors that are most associated with the observed microbiome characteristics. The authors begin by validating their results, comparing them to previous microbiome studies of catheterized urine, midstream voided urine, the vagina, and stool. Their results compared favorably to the urine studies but were distinct from vaginal and especially stool microbiomes, confirming an earlier report (Thomas-White et al., 2018aThomas-White K. Forster S.C. Kumar N. Van Kuiken M. Putonti C. Stares M.D. Hilt E.E. Price T.K. Wolfe A.J. Lawley T.D. Culturing of female bladder bacteria reveals an interconnected urogenital microbiota.Nat. Commun. 2018; 9: 1557Crossref PubMed Scopus (145) Google Scholar). Since the current study is by far the largest (by almost 10-fold), the authors were able to confirm the existence of a core genitourinary microbiome for older women. The most common phyla were Firmicutes (Lactobacillus, Streptococcus, Peptoniphilus), Bacteroidetes (Prevotella), Proteobacteria (Escherichia-Shigella), and Actinobacteria (Gardnerella, Corynebacteria, Atopobium, Actinotignum), similar to previous reports of smaller studies (e.g., Pearce et al., 2015Pearce M.M. Zilliox M.J. Rosenfeld A.B. Thomas-White K.J. Richter H.E. Nager C.W. Visco A.G. Nygaard I.E. Barber M.D. Schaffer J. et al.The female urinary microbiome in urgency urinary incontinence.Am J Obstet Gynecol. 2015; 213 (347 e341-311)Abstract Full Text Full Text PDF PubMed Scopus (170) Google Scholar; Price et al., 2020Price T.K. Hilt E.E. Thomas-White K. Mueller E.R. Wolfe A.J. Brubaker L. The urobiome of continent adult women: a cross-sectional study.BJOG. 2020; 127: 193-201Crossref PubMed Scopus (47) Google Scholar; Thomas-White et al., 2018aThomas-White K. Forster S.C. Kumar N. Van Kuiken M. Putonti C. Stares M.D. Hilt E.E. Price T.K. Wolfe A.J. Lawley T.D. Culturing of female bladder bacteria reveals an interconnected urogenital microbiota.Nat. Commun. 2018; 9: 1557Crossref PubMed Scopus (145) Google Scholar). Certain taxa appeared to co-occur, suggesting the existence of specific microbial consortia. In the current study, the investigators compared mono- and dizygotic twins using four distinct approaches to test the hypothesis that host genetic factors influence the urinary tract microbiome. They found that many microbial taxa are indeed heritable, and some of these are clinically relevant. For example, clinical care of adult women with UTIs remains a major source of systemic antibiotic use, and the therapeutic approach has not meaningfully changed in decades, despite the increasing awareness of antibiotic-associated collateral effects and harms (Abeles et al., 2016Abeles S.R. Jones M.B. Santiago-Rodriguez T.M. Ly M. Klitgord N. Yooseph S. Nelson K.E. Pride D.T. Microbial diversity in individuals and their household contacts following typical antibiotic courses.Microbiome. 2016; 4: 39Crossref PubMed Scopus (90) Google Scholar). In UTIs, it is commonly accepted that clinical symptoms are caused by a certain subset of microbes—most commonly Escherichia-Shigella. However, as the present study and another recent report (Price et al., 2020Price T.K. Hilt E.E. Thomas-White K. Mueller E.R. Wolfe A.J. Brubaker L. The urobiome of continent adult women: a cross-sectional study.BJOG. 2020; 127: 193-201Crossref PubMed Scopus (47) Google Scholar) show, this genus is commonly present in older women without UTI-like symptoms. Other heritable species may be beneficial. For example, Lactobacillus iners was previously shown to be protective against post-operative UTI (Thomas-White et al., 2018bThomas-White K.J. Gao X. Lin H. Fok C.S. Ghanayem K. Mueller E.R. Dong Q. Brubaker L. Wolfe A.J. Urinary microbes and postoperative urinary tract infection risk in urogynecologic surgical patients.Int. Urogynecol. J. Pelvic Floor Dysfunct. 2018; 29: 1797-1805Crossref PubMed Scopus (63) Google Scholar). Among the strongest factors defining the urobiome (age, menopausal status, host genetics, and prior UTI), prior UTI stands out as the only modifiable factor. This finding reveals an opportunity to improve clinical care of women with UTIs and the associated use of antibiotics. From a pragmatic clinical standpoint, antibiotics are prescribed for “typical” symptoms with little to no urine testing. Even in women affected by recurrent UTIs (defined as culture-proven events twice in 6 months or three times in 12 months), antibiotic therapy is not consistent with existing guidelines that recommend urine culture testing. A woman’s recall of UTI events is generally related to symptoms with subsequent antibiotic use; however, as with most non-life-threatening health conditions, recall of distant events is poor. Nonetheless, the history of past UTI conflates both the symptoms episode (diagnosis) and the treatment (antibiotic), both of which can alter urobiome health. In the authors’ analysis, the changes in urobiome diversity were not analyzed by the interval between prior antibiotics; however, long-term microbiome changes in other niches have been documented following even brief exposure to systemic antibiotics (Abeles et al., 2016Abeles S.R. Jones M.B. Santiago-Rodriguez T.M. Ly M. Klitgord N. Yooseph S. Nelson K.E. Pride D.T. Microbial diversity in individuals and their household contacts following typical antibiotic courses.Microbiome. 2016; 4: 39Crossref PubMed Scopus (90) Google Scholar). The marked difference between the midstream voided urine and stool microbiomes is not surprising (Adebayo et al., 2020Adebayo A.S. Ackermann G. Bowyer R.C.E. Wells P.M. Humphreys G. Knight R. Spector T.D. Steves C.J. The urinary tract microbiome in older women exhibits host genetic and environmental influences.Cell Host Microbe. 2020; 28 (this issue): 298-305Abstract Full Text Full Text PDF PubMed Scopus (20) Google Scholar). This finding extends the previous report that the microbes in catheterized urine and stool differ dramatically (Thomas-White et al., 2018aThomas-White K. Forster S.C. Kumar N. Van Kuiken M. Putonti C. Stares M.D. Hilt E.E. Price T.K. Wolfe A.J. Lawley T.D. Culturing of female bladder bacteria reveals an interconnected urogenital microbiota.Nat. Commun. 2018; 9: 1557Crossref PubMed Scopus (145) Google Scholar) and will help clinicians and clinical microbiologists interpret voided urine samples. Although the urinary and vaginal microbiomes are similar, there are some clear distinctions (Adebayo et al., 2020Adebayo A.S. Ackermann G. Bowyer R.C.E. Wells P.M. Humphreys G. Knight R. Spector T.D. Steves C.J. The urinary tract microbiome in older women exhibits host genetic and environmental influences.Cell Host Microbe. 2020; 28 (this issue): 298-305Abstract Full Text Full Text PDF PubMed Scopus (20) Google Scholar; Thomas-White et al., 2018aThomas-White K. Forster S.C. Kumar N. Van Kuiken M. Putonti C. Stares M.D. Hilt E.E. Price T.K. Wolfe A.J. Lawley T.D. Culturing of female bladder bacteria reveals an interconnected urogenital microbiota.Nat. Commun. 2018; 9: 1557Crossref PubMed Scopus (145) Google Scholar). This also should not be surprising. Although the lower urinary tract and the vagina are in close proximity, they have vastly different biological functions. The authors’ careful quantification of the microbial differences of these two niches at a single point in time is helpful, and it should guide investigators who are planning longitudinal urobiome studies. Data from a single point in time precludes causative inferences, and thus the authors’ findings highlight the need for rigorous longitudinal studies, especially of women with recurrent UTIs. Longitudinal microbiome assessments should help advance clinical care by refining UTI diagnosis and treatment. In the cohorts that have been studied to date, investigators reliably report a significant proportion of sequence-negative samples (Pearce et al., 2015Pearce M.M. Zilliox M.J. Rosenfeld A.B. Thomas-White K.J. Richter H.E. Nager C.W. Visco A.G. Nygaard I.E. Barber M.D. Schaffer J. et al.The female urinary microbiome in urgency urinary incontinence.Am J Obstet Gynecol. 2015; 213 (347 e341-311)Abstract Full Text Full Text PDF PubMed Scopus (170) Google Scholar; Thomas-White et al., 2018bThomas-White K.J. Gao X. Lin H. Fok C.S. Ghanayem K. Mueller E.R. Dong Q. Brubaker L. Wolfe A.J. Urinary microbes and postoperative urinary tract infection risk in urogynecologic surgical patients.Int. Urogynecol. J. Pelvic Floor Dysfunct. 2018; 29: 1797-1805Crossref PubMed Scopus (63) Google Scholar). Thus, another intriguing aspect of the TwinUK cohort urobiome research is the finding that some host-specific factors (age and health status) may relate to urobiome microbial biomass (in terms of read count). The association of younger age and better health with low urobiome biomass suggests that increased biomass may increase susceptibility to adverse health states, which is consistent with clinical observations that women have increased risk for lower urinary tract symptoms and UTI with aging. There is much to learn about the human urobiome. The longitudinal changes of the urobiome remain a mystery, with scant information to inform our knowledge of when the urobiome becomes established, how it is maintained, how it functions, and how it recovers from perturbations and disruptions. It is also not known whether genetic factors affect vulnerability to UTI. In discussions with women affected by frequent UTI, however, clinicians often hear that the problem “runs in the family.” This large cohort of twins may provide impactful insights into changes over time, as well as insights into specific risk and protective factors for bladder health. Previously reported correlations between the urobiome and common lower urinary tract symptoms are intriguing, but require further study (Mueller et al., 2017Mueller E.R. Wolfe A.J. Brubaker L. Female urinary microbiota.Curr. Opin. Urol. 2017; 27: 282-286Crossref PubMed Scopus (42) Google Scholar; Thomas-White et al., 2016Thomas-White K. Brady M. Wolfe A.J. Mueller E.R. The bladder is not sterile: History and current discoveries on the urinary microbiome.Curr. Bladder Dysfunct. Rep. 2016; 11: 18-24Crossref PubMed Scopus (80) Google Scholar). Future studies will impact human health by improving our understanding of causal relationships for urobiome differences and human urinary health. Adebayo and colleagues have demonstrated the usefulness of appropriately interpreting voided urine specimens, which is critical to advancing urobiome research. This work represents a significant advance that paves the way for other large-scale, population-based studies in this field. Given the high prevalence of common lower urinary tract disorders and the stagnation of clinical advances, the discovery of the urobiome and progression of urobiome research hold great promise in improving human health and reducing the impact of lower urinary tract symptoms and disorders. Drs. Wolfe and Brubaker are supported by a grant from the National Institutes of Health (R01 DK104718). Dr. Brubaker discloses editorial stipends from JAMA, Female Pelvic Medicine and Reconstructive Surgery, and UpToDate. Dr. Wolfe discloses membership on the Advisory Board of Urobiome Therapeutics and research support from Astellas Scientific and Medical Affairs and the Kimberly Clark Corporation. The Urinary Tract Microbiome in Older Women Exhibits Host Genetic and Environmental InfluencesAdebayo et al.Cell Host & MicrobeJuly 21, 2020In BriefAdebayo et al. explore microbes present in the urine of community-dwelling women without clinically active infection. They found 61 common core microbes and showed that the microbiome differed from those in stool. Age, genetics, and other host factors contributed to urinary microbial variation. Full-Text PDF Open Archive" @default.
• W3048844710 created "2020-08-18" @default.
• W3048844710 creator A5006559972 @default.
• W3048844710 creator A5058388672 @default.
• W3048844710 date "2020-08-01" @default.
• W3048844710 modified "2023-10-16" @default.
• W3048844710 title "Ur-ine Old Age: Urinary Microbiome of Older Community Dwelling Women" @default.
• W3048844710 cites W1834656240 @default.
• W3048844710 cites W1967961996 @default.
• W3048844710 cites W2291217197 @default.
• W3048844710 cites W2500271699 @default.
• W3048844710 cites W2590210953 @default.
• W3048844710 cites W2802103894 @default.
• W3048844710 cites W2894338204 @default.
• W3048844710 cites W2971194364 @default.
• W3048844710 cites W2973501885 @default.
• W3048844710 cites W3045111402 @default.
• W3048844710 doi "https://doi.org/10.1016/j.chom.2020.07.012" @default.
• W3048844710 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32791105" @default.
• W3048844710 hasPublicationYear "2020" @default.
• W3048844710 type Work @default.
• W3048844710 sameAs 3048844710 @default.
• W3048844710 citedByCount "0" @default.
• W3048844710 crossrefType "journal-article" @default.
• W3048844710 hasAuthorship W3048844710A5006559972 @default.
• W3048844710 hasAuthorship W3048844710A5058388672 @default.
• W3048844710 hasBestOaLocation W30488447101 @default.
• W3048844710 hasConcept C134018914 @default.
• W3048844710 hasConcept C143121216 @default.
• W3048844710 hasConcept C42407357 @default.
• W3048844710 hasConcept C60644358 @default.
• W3048844710 hasConcept C71924100 @default.
• W3048844710 hasConcept C74909509 @default.
• W3048844710 hasConcept C77411442 @default.
• W3048844710 hasConcept C86803240 @default.
• W3048844710 hasConceptScore W3048844710C134018914 @default.
• W3048844710 hasConceptScore W3048844710C143121216 @default.
• W3048844710 hasConceptScore W3048844710C42407357 @default.
• W3048844710 hasConceptScore W3048844710C60644358 @default.
• W3048844710 hasConceptScore W3048844710C71924100 @default.
• W3048844710 hasConceptScore W3048844710C74909509 @default.
• W3048844710 hasConceptScore W3048844710C77411442 @default.
• W3048844710 hasConceptScore W3048844710C86803240 @default.
• W3048844710 hasFunder F4320332161 @default.
• W3048844710 hasIssue "2" @default.
• W3048844710 hasLocation W30488447101 @default.
• W3048844710 hasLocation W30488447102 @default.
• W3048844710 hasOpenAccess W3048844710 @default.
• W3048844710 hasPrimaryLocation W30488447101 @default.
• W3048844710 hasRelatedWork W2323743391 @default.
• W3048844710 hasRelatedWork W2424057235 @default.
• W3048844710 hasRelatedWork W2554729895 @default.
• W3048844710 hasRelatedWork W2902095886 @default.
• W3048844710 hasRelatedWork W3039192128 @default.
• W3048844710 hasRelatedWork W3082140264 @default.
• W3048844710 hasRelatedWork W3122465478 @default.
• W3048844710 hasRelatedWork W3162009868 @default.
• W3048844710 hasRelatedWork W3207722343 @default.
• W3048844710 hasRelatedWork W4298127660 @default.
• W3048844710 hasVolume "28" @default.
• W3048844710 isParatext "false" @default.
• W3048844710 isRetracted "false" @default.
• W3048844710 magId "3048844710" @default.
• W3048844710 workType "article" @default.