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- W3048846500 abstract "Abstract We used controlled human malaria infection (CHMI) to study naturally acquired immunity of Kenyan adults. We administered 3.2×10 3 cryopreserved Plasmodium falciparum sporozoites (SPZ, NF54 West African strain) and undertook clinical monitoring and serial quantitative PCR (qPCR). Of the 142 volunteers who were eligible for analysis: 26 (18.3%) had febrile symptoms and were treated; 30 (21.1%) reached ≥500 parasites/μl and were treated; 53 (37.3%) had parasitaemia without meeting thresholds for treatment and; 33 (23.2%) remained qPCR negative. We find that the immunity acquired by some Kenyan adults can completely suppress in vivo growth of a parasite strain originating from outside Kenya." @default.
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- W3048846500 date "2020-08-11" @default.
- W3048846500 modified "2023-10-16" @default.
- W3048846500 title "Naturally acquired immunity among Kenyan adults suppresses the West African P. falciparum NF54 strain in controlled human malaria infection (CHMI)" @default.
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- W3048846500 doi "https://doi.org/10.1101/2020.08.11.20172411" @default.
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