FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3048848035> ?p ?o ?g. }

• W3048848035 endingPage "314" @default.
• W3048848035 startingPage "308" @default.
• W3048848035 abstract "ObjectiveTo evaluate the efficacy and safety of aromatase inhibitor letrozole in treatment of male adolescents with idiopathic short stature (ISS). MethodSeventy five boys with height less than 2 standard deviation (SD) below the mean who had entered puberty were enrolled in our study from 2004 to 2017, in the Pediatric Department of the First Affiliated Hospital, Sun Yat-Sen University. Among 75 patients, 28 in letrozole group received letrozole and spironolactone, 30 in gonadotrophin releasing hormone analogue (GnRHa) group received GnRHa injection and 17 had no intervention. Height velocity (HV), increment of bone age/chronological age (ΔBA/ΔCA), the final adult height (FAH) were compared among groups and the safety of letrozole treatment was evaluated. ResultsHV maintained faster during letrozole treatment when compared with other groups. HV during GnRHa treatment showed slightly decline in the first 6 months, but decreased remarkably after 6 months, and was significantly lower than that in letrozole group ( P < 0.05). The maturation of BA slowed down in both letrozole and GnRHa groups. But the ΔBA/ΔCA in letrozole group during the first and the second year of treatment were significantly higher (0.67±0.09, 0.50±0.15, respectively) when compared with GnRHa group (0.59±0.16, 0.44±0.13, respectively) ( t=2.78 and 2.20, all P < 0.05). FAH in letrozole group and GnRHa group were (170±4) cm and (170±6)cm, there was no significant differences between the two groups ( P>0.05), and both were higher than that in no intervention group (162±4 cm, P < 0.01). After 6 months of letrozole treatment, testicular volumes and serum testerone levels increased; 39.2% (11/28) boys had clinical manifestations of hyperandrogenemia, and 82.1% (23/28) boys had decreased serum high-density lipoprotein (HDL) levels. Serum levels of HDL and testerone returned normal and the hyperandrogenemia disappeared after the cessation of letrozole treatment. No significant changes in serum triglyceride, serum low-density lipoprotein (LDL), fating serum levels of insulin and glucose, HOMA-IR were observed. No abnormal liver function, myalgia, scoliosis or aggravations of scoliosis was found. ConclusionsLong term letrozole therapy during puberty in boys with ISS can delay bone maturation without significant decrease of linear growth, and thus can improve the final adult height. No severe adverse reactions were found." @default.
• W3048848035 created "2020-08-18" @default.
• W3048848035 creator A5003376539 @default.
• W3048848035 creator A5006710364 @default.
• W3048848035 creator A5040579986 @default.
• W3048848035 creator A5047528935 @default.
• W3048848035 creator A5054374657 @default.
• W3048848035 creator A5064435064 @default.
• W3048848035 date "2020-05-25" @default.
• W3048848035 modified "2023-09-23" @default.
• W3048848035 title "[Efficacy of letrozole in treatment of male adolescents with idiopathic short stature]." @default.
• W3048848035 cites W188521429 @default.
• W3048848035 cites W1975579760 @default.
• W3048848035 cites W1988888689 @default.
• W3048848035 cites W1992428739 @default.
• W3048848035 cites W2023705303 @default.
• W3048848035 cites W2048800355 @default.
• W3048848035 cites W2057213082 @default.
• W3048848035 cites W2068535561 @default.
• W3048848035 cites W2079935466 @default.
• W3048848035 cites W2147079981 @default.
• W3048848035 cites W2285696050 @default.
• W3048848035 cites W2321613759 @default.
• W3048848035 cites W2324075496 @default.
• W3048848035 cites W2410010904 @default.
• W3048848035 cites W2416153234 @default.
• W3048848035 cites W2529804209 @default.
• W3048848035 cites W2592087460 @default.
• W3048848035 cites W2923842799 @default.
• W3048848035 cites W2924582419 @default.
• W3048848035 cites W2970643178 @default.
• W3048848035 doi "https://doi.org/10.3785/j.issn.1008-9292.2020.04.05" @default.
• W3048848035 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32762161" @default.
• W3048848035 hasPublicationYear "2020" @default.
• W3048848035 type Work @default.
• W3048848035 sameAs 3048848035 @default.
• W3048848035 citedByCount "1" @default.
• W3048848035 countsByYear W30488480352023 @default.
• W3048848035 crossrefType "journal-article" @default.
• W3048848035 hasAuthorship W3048848035A5003376539 @default.
• W3048848035 hasAuthorship W3048848035A5006710364 @default.
• W3048848035 hasAuthorship W3048848035A5040579986 @default.
• W3048848035 hasAuthorship W3048848035A5047528935 @default.
• W3048848035 hasAuthorship W3048848035A5054374657 @default.
• W3048848035 hasAuthorship W3048848035A5064435064 @default.
• W3048848035 hasConcept C121608353 @default.
• W3048848035 hasConcept C126322002 @default.
• W3048848035 hasConcept C134018914 @default.
• W3048848035 hasConcept C2776166826 @default.
• W3048848035 hasConcept C2777871287 @default.
• W3048848035 hasConcept C2778504769 @default.
• W3048848035 hasConcept C2778754045 @default.
• W3048848035 hasConcept C2778812593 @default.
• W3048848035 hasConcept C2910124714 @default.
• W3048848035 hasConcept C2984496839 @default.
• W3048848035 hasConcept C530470458 @default.
• W3048848035 hasConcept C71315377 @default.
• W3048848035 hasConcept C71924100 @default.
• W3048848035 hasConcept C89551170 @default.
• W3048848035 hasConceptScore W3048848035C121608353 @default.
• W3048848035 hasConceptScore W3048848035C126322002 @default.
• W3048848035 hasConceptScore W3048848035C134018914 @default.
• W3048848035 hasConceptScore W3048848035C2776166826 @default.
• W3048848035 hasConceptScore W3048848035C2777871287 @default.
• W3048848035 hasConceptScore W3048848035C2778504769 @default.
• W3048848035 hasConceptScore W3048848035C2778754045 @default.
• W3048848035 hasConceptScore W3048848035C2778812593 @default.
• W3048848035 hasConceptScore W3048848035C2910124714 @default.
• W3048848035 hasConceptScore W3048848035C2984496839 @default.
• W3048848035 hasConceptScore W3048848035C530470458 @default.
• W3048848035 hasConceptScore W3048848035C71315377 @default.
• W3048848035 hasConceptScore W3048848035C71924100 @default.
• W3048848035 hasConceptScore W3048848035C89551170 @default.
• W3048848035 hasIssue "3" @default.
• W3048848035 hasLocation W30488480351 @default.
• W3048848035 hasOpenAccess W3048848035 @default.
• W3048848035 hasPrimaryLocation W30488480351 @default.
• W3048848035 hasRelatedWork W11117660 @default.
• W3048848035 hasRelatedWork W12034364 @default.
• W3048848035 hasRelatedWork W15499078 @default.
• W3048848035 hasRelatedWork W16192348 @default.
• W3048848035 hasRelatedWork W16461996 @default.
• W3048848035 hasRelatedWork W18535981 @default.
• W3048848035 hasRelatedWork W20750182 @default.
• W3048848035 hasRelatedWork W7756613 @default.
• W3048848035 hasRelatedWork W7839704 @default.
• W3048848035 hasRelatedWork W8960856 @default.
• W3048848035 hasVolume "49" @default.
• W3048848035 isParatext "false" @default.
• W3048848035 isRetracted "false" @default.
• W3048848035 magId "3048848035" @default.
• W3048848035 workType "article" @default.