FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3048851551> ?p ?o ?g. }

• W3048851551 endingPage "114007" @default.
• W3048851551 startingPage "114007" @default.
• W3048851551 abstract "New conjugated derivative of pteridine and benzimidazole, 7-(benzimidazol-2-yl)-6-(2,4-dichlorophenyl)-2-thioxo-2,3-dihydropteridin-4(1H)-one (BP) possessing antitumor activity was obtained and thoroughly characterized; its spectrophotometry control in solution was developed. To improve the solubility of the hydrophobic antitumor agent BP in aqueous solutions, amphiphilic systems (micellar solutions and modified liposomes) were fabricated, with their composition optimized. Stable 1,2-dipalmitoyl-sn-glycero-3-phosphocholine (DPPC)-based liposomes modified with cationic surfactants, namely cetyltrimetylammonium bromide and 1-methyl-3-hexadecylimidazolium bromide (IA-16), were obtained. It was shown that the use of cationic surfactants for the formation of hybrid drug carriers and varying of the surfactant/lipid molar ratios can be the key factor for obtaining the optimized particles with high efficiency of encapsulation, favorable loading efficacy and prolonged release of the drug. The most beneficial parameters in terms of stability and loading/release efficacy were obtained for IA-16/DPPC hybrid liposomes with the surfactant/lipid molar ratio of 1:50. Free BP demonstrated cytotoxicity toward M-Hela tumor cells, along with the nearly the same toxic effect toward normal Chang liver cells. Importantly, double effect occurred upon the encapsulation of BP into hybrid cationic liposomes, i.e. a sharp decrease in viability of diseased cells and increase of viability of normal cells. Therefore, liposomal BP formulation can be recommended as therapeutics with improved stability and high selective cytotoxicity toward M-Hela tumor cells at the level of commercial drug doxorubicin, in combination with much less toxicity (by 37 times) toward the normal Chang liver cell line." @default.
• W3048851551 created "2020-08-18" @default.
• W3048851551 creator A5012647808 @default.
• W3048851551 creator A5013571899 @default.
• W3048851551 creator A5017395617 @default.
• W3048851551 creator A5044416535 @default.
• W3048851551 creator A5062700207 @default.
• W3048851551 creator A5068243422 @default.
• W3048851551 creator A5071365764 @default.
• W3048851551 creator A5071517532 @default.
• W3048851551 creator A5076766087 @default.
• W3048851551 creator A5081676729 @default.
• W3048851551 creator A5085140054 @default.
• W3048851551 date "2020-11-01" @default.
• W3048851551 modified "2023-10-05" @default.
• W3048851551 title "Soft nanocarriers for new poorly soluble conjugate of pteridine and benzimidazole: Synthesis and cytotoxic activity against tumor cells" @default.
• W3048851551 cites W1486949824 @default.
• W3048851551 cites W1635459556 @default.
• W3048851551 cites W1906147654 @default.
• W3048851551 cites W19547836 @default.
• W3048851551 cites W1963553127 @default.
• W3048851551 cites W1963773275 @default.
• W3048851551 cites W1965765803 @default.
• W3048851551 cites W1967515426 @default.
• W3048851551 cites W1977338874 @default.
• W3048851551 cites W1978537309 @default.
• W3048851551 cites W1978801954 @default.
• W3048851551 cites W1988371680 @default.
• W3048851551 cites W1988579458 @default.
• W3048851551 cites W1999467850 @default.
• W3048851551 cites W2001322263 @default.
• W3048851551 cites W2005244982 @default.
• W3048851551 cites W2008191801 @default.
• W3048851551 cites W2012525588 @default.
• W3048851551 cites W2013765163 @default.
• W3048851551 cites W2017380386 @default.
• W3048851551 cites W2022272976 @default.
• W3048851551 cites W2032908499 @default.
• W3048851551 cites W2041850496 @default.
• W3048851551 cites W2048179618 @default.
• W3048851551 cites W2053303244 @default.
• W3048851551 cites W2079095768 @default.
• W3048851551 cites W2080043305 @default.
• W3048851551 cites W2096552337 @default.
• W3048851551 cites W2096681702 @default.
• W3048851551 cites W2121297632 @default.
• W3048851551 cites W2132323316 @default.
• W3048851551 cites W2135486341 @default.
• W3048851551 cites W2143132863 @default.
• W3048851551 cites W2168986531 @default.
• W3048851551 cites W2180765374 @default.
• W3048851551 cites W2325266448 @default.
• W3048851551 cites W2329006400 @default.
• W3048851551 cites W2340236357 @default.
• W3048851551 cites W2554518393 @default.
• W3048851551 cites W2564567560 @default.
• W3048851551 cites W2610617996 @default.
• W3048851551 cites W2616830422 @default.
• W3048851551 cites W2734926529 @default.
• W3048851551 cites W2740088189 @default.
• W3048851551 cites W2748514225 @default.
• W3048851551 cites W2761994788 @default.
• W3048851551 cites W2768018208 @default.
• W3048851551 cites W2773477388 @default.
• W3048851551 cites W2777340203 @default.
• W3048851551 cites W2783525033 @default.
• W3048851551 cites W2795721299 @default.
• W3048851551 cites W2808830750 @default.
• W3048851551 cites W2810417738 @default.
• W3048851551 cites W2884203840 @default.
• W3048851551 cites W2885628094 @default.
• W3048851551 cites W2891366627 @default.
• W3048851551 cites W2891582847 @default.
• W3048851551 cites W2892401646 @default.
• W3048851551 cites W2894465817 @default.
• W3048851551 cites W2897249724 @default.
• W3048851551 cites W2898391111 @default.
• W3048851551 cites W2898883627 @default.
• W3048851551 cites W2900128797 @default.
• W3048851551 cites W2900920506 @default.
• W3048851551 cites W2904562410 @default.
• W3048851551 cites W2906919625 @default.
• W3048851551 cites W2908265615 @default.
• W3048851551 cites W2912083123 @default.
• W3048851551 cites W2915501339 @default.
• W3048851551 cites W2917545014 @default.
• W3048851551 cites W2921922120 @default.
• W3048851551 cites W2922392323 @default.
• W3048851551 cites W2942515607 @default.
• W3048851551 cites W2948634346 @default.
• W3048851551 cites W2951084010 @default.
• W3048851551 cites W2952675088 @default.
• W3048851551 cites W2959420905 @default.
• W3048851551 cites W2963427362 @default.
• W3048851551 cites W2963922997 @default.
• W3048851551 cites W2982637465 @default.
• W3048851551 cites W2985964398 @default.
• W3048851551 doi "https://doi.org/10.1016/j.molliq.2020.114007" @default.

• next