FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3048852451> ?p ?o ?g. }

• W3048852451 abstract "Cardiovascular (CV) diseases are the leading cause of mortality and morbidity in patients with type 2 diabetes mellitus (DM). Therefore, there has been an increasing endorsement from diabetic associations across the globe for the use of anti-diabetic drugs, which not only provide not only glycemic control but also have cardioprotective effects. Sodium-glucose co-transporter type 2 (SGLT2) inhibitors are one class of drugs that have shown evidence of CV benefits in patients with type 2 DM. We reviewed the published literature and found five adequately powered clinical trials that evaluated the CV effects of SGLT2 inhibitors in type 2 DM patients. These trials assessed the CV effect of three SGLT2 inhibitors, namely, empagliflozin, canagliflozin, and dapagliflozin. It was found that all these clinical trials were multi-centric and conducted in and after 2015 across different parts of the World, enrolling type 2 DM patients with varied baseline characteristics in terms of age, BMI, sex, glomerular filtration rate, history of existing renal diseases, etc. In spite of these differences, the SGLT2 drugs were found to be beneficial by significantly reducing all-cause mortality, mortality due to CV causes, and risk of major CV events. All the studies highlighted the cardioprotective effect of SGLT-2 inhibitors, especially empagliflozin, dapagliflozin, and canagliflozin in type 2 DM patients with established CV disease, but the studies could not find significant improvement in 3P-MACE (three-point major adverse CV event) indicators offered by these drugs except empagliflozin. Hence, adequately powered clinical trials with long follow-up durations are the need of the hour to address this issue specifically." @default.
• W3048852451 created "2020-08-18" @default.
• W3048852451 creator A5047680710 @default.
• W3048852451 creator A5068055561 @default.
• W3048852451 date "2020-08-11" @default.
• W3048852451 modified "2023-09-23" @default.
• W3048852451 title "Evidence-Based Clinical Review on Cardiovascular Benefits of SGLT2 (Sodium-Glucose Co-Transporter Type 2) Inhibitors in Type 2 Diabetes Mellitus" @default.
• W3048852451 cites W2002810160 @default.
• W3048852451 cites W2043807347 @default.
• W3048852451 cites W2050160827 @default.
• W3048852451 cites W2131964379 @default.
• W3048852451 cites W2146264128 @default.
• W3048852451 cites W2160569073 @default.
• W3048852451 cites W2419167869 @default.
• W3048852451 cites W2444268874 @default.
• W3048852451 cites W2510990897 @default.
• W3048852451 cites W2564161563 @default.
• W3048852451 cites W2581368499 @default.
• W3048852451 cites W2600252375 @default.
• W3048852451 cites W2626446274 @default.
• W3048852451 cites W2756191633 @default.
• W3048852451 cites W2768576350 @default.
• W3048852451 cites W2793012836 @default.
• W3048852451 cites W2806548984 @default.
• W3048852451 cites W2887650349 @default.
• W3048852451 cites W2894993577 @default.
• W3048852451 cites W2899764361 @default.
• W3048852451 cites W2900413769 @default.
• W3048852451 cites W2907263162 @default.
• W3048852451 cites W2914038117 @default.
• W3048852451 cites W2921866736 @default.
• W3048852451 cites W2939222610 @default.
• W3048852451 cites W2941506137 @default.
• W3048852451 cites W2965056983 @default.
• W3048852451 cites W2971147579 @default.
• W3048852451 cites W2972869264 @default.
• W3048852451 cites W2974260792 @default.
• W3048852451 cites W2990869853 @default.
• W3048852451 cites W2992022999 @default.
• W3048852451 cites W3003318708 @default.
• W3048852451 cites W3006073804 @default.
• W3048852451 cites W3006492268 @default.
• W3048852451 doi "https://doi.org/10.7759/cureus.9655" @default.
• W3048852451 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7419148" @default.
• W3048852451 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32802621" @default.
• W3048852451 hasPublicationYear "2020" @default.
• W3048852451 type Work @default.
• W3048852451 sameAs 3048852451 @default.
• W3048852451 citedByCount "0" @default.
• W3048852451 crossrefType "journal-article" @default.
• W3048852451 hasAuthorship W3048852451A5047680710 @default.
• W3048852451 hasAuthorship W3048852451A5068055561 @default.
• W3048852451 hasBestOaLocation W30488524511 @default.
• W3048852451 hasConcept C126322002 @default.
• W3048852451 hasConcept C134018914 @default.
• W3048852451 hasConcept C197934379 @default.
• W3048852451 hasConcept C2775887513 @default.
• W3048852451 hasConcept C2777180221 @default.
• W3048852451 hasConcept C2777422806 @default.
• W3048852451 hasConcept C2777451236 @default.
• W3048852451 hasConcept C2779306644 @default.
• W3048852451 hasConcept C2780473172 @default.
• W3048852451 hasConcept C2780739214 @default.
• W3048852451 hasConcept C2910068830 @default.
• W3048852451 hasConcept C45393284 @default.
• W3048852451 hasConcept C500558357 @default.
• W3048852451 hasConcept C535046627 @default.
• W3048852451 hasConcept C555293320 @default.
• W3048852451 hasConcept C71924100 @default.
• W3048852451 hasConcept C98274493 @default.
• W3048852451 hasConceptScore W3048852451C126322002 @default.
• W3048852451 hasConceptScore W3048852451C134018914 @default.
• W3048852451 hasConceptScore W3048852451C197934379 @default.
• W3048852451 hasConceptScore W3048852451C2775887513 @default.
• W3048852451 hasConceptScore W3048852451C2777180221 @default.
• W3048852451 hasConceptScore W3048852451C2777422806 @default.
• W3048852451 hasConceptScore W3048852451C2777451236 @default.
• W3048852451 hasConceptScore W3048852451C2779306644 @default.
• W3048852451 hasConceptScore W3048852451C2780473172 @default.
• W3048852451 hasConceptScore W3048852451C2780739214 @default.
• W3048852451 hasConceptScore W3048852451C2910068830 @default.
• W3048852451 hasConceptScore W3048852451C45393284 @default.
• W3048852451 hasConceptScore W3048852451C500558357 @default.
• W3048852451 hasConceptScore W3048852451C535046627 @default.
• W3048852451 hasConceptScore W3048852451C555293320 @default.
• W3048852451 hasConceptScore W3048852451C71924100 @default.
• W3048852451 hasConceptScore W3048852451C98274493 @default.
• W3048852451 hasLocation W30488524511 @default.
• W3048852451 hasLocation W30488524512 @default.
• W3048852451 hasLocation W30488524513 @default.
• W3048852451 hasOpenAccess W3048852451 @default.
• W3048852451 hasPrimaryLocation W30488524511 @default.
• W3048852451 hasRelatedWork W1976944453 @default.
• W3048852451 hasRelatedWork W2336452419 @default.
• W3048852451 hasRelatedWork W2736637978 @default.
• W3048852451 hasRelatedWork W2771047550 @default.
• W3048852451 hasRelatedWork W3005613213 @default.
• W3048852451 hasRelatedWork W3081222781 @default.
• W3048852451 hasRelatedWork W3109685549 @default.
• W3048852451 hasRelatedWork W3188626867 @default.

• next