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- W3048854639 abstract "Abstract Objective To determine the role of vascular endothelial growth factor (VEGF) in placental hypoperfusion in obesity. Methods The prospective study enrolled women with a first‐trimester singleton pregnancy in Izmir, Turkey, between January and April 2011. Participants were divided into three groups: obese (body mass index [BMI, calculated as weight in kilograms divided by the square of height in meters] >30) with cesarean delivery; normal weight (BMI <30) with vaginal delivery (NVD); and healthy controls (BMI <30) with cesarean delivery. Before delivery, serum C‐reactive protein (CRP), and uterine and fetal Doppler measurements were taken. VEGF was evaluated immunohistochemically from the umbilical cord. Results Overall, 109 women completed the study: obesity group (n=13, 11.9%), NVD group (n=50, 45.9%), and control group (n=46, 42.2%). Serum CRP was higher in the obesity group than in the control or NVD groups ( P =0.009). VEGF score was highest in the NVD group (9.39 ± 3.11), and lowest in the obesity group (4.58 ± 2.78) ( P <0.001). VEGF score decreased by 0.81 for each increase in BMI of 1 ( P =0.002). Conclusions Maternal obesity was related to decreased VEGF expression. Although not supported by Doppler findings, decreased VEGF expression owing to maternal obesity might trigger endothelial dysfunction and inflammation." @default.
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- W3048854639 date "2020-09-10" @default.
- W3048854639 modified "2023-09-26" @default.
- W3048854639 title "Effect of vascular endothelial growth factor on fetal vessels among obese pregnant women" @default.
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- W3048854639 doi "https://doi.org/10.1002/ijgo.13346" @default.
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