Matches in SemOpenAlex for { <https://semopenalex.org/work/W3048854645> ?p ?o ?g. }
- W3048854645 endingPage "183" @default.
- W3048854645 startingPage "170" @default.
- W3048854645 abstract "Paraquat (PQ) poisoning-induced pulmonary fibrosis always results in fatal harm to patients. Our study aimed to investigate the functions of the Wnt/β-catenin pathway in PQ-induced pulmonary fibrosis. By comparing the proteomic profiles of rat lung tissues using protein array in the absence or presence of PQ, the Wnt/β-catenin signaling, as a fibrosis-related pathway, was discovered to be profoundly activated by PQ. The protein levels of Wnt/β-catenin signaling components including MMP-2, β-catenin, Wnt3a, Wnt10b, Cyclin D1, and WISP1 were increased in PQ-treated rat lung tissues. Surprisingly, PQ was found to be able to promote lung epithelial cells and fibroblasts differentiating into myofibroblasts by activating Wnt/β-catenin signaling pathway. Dickkopf-1 (DKK1), an antagonist of Wnt/β-catenin signaling pathway, could inhibit the myofibroblast differentiation and attenuate PQ-induced pulmonary fibrogenesis in vitro and in vivo. The expression levels of fibroblasts markers Vimentin, α-smooth muscle actin (α-SMA) and Collagen I was detected and found to be increased when PQ treated and restored with additional DKK1 treatment. In summary, these assays indicated that Wnt/β-catenin signaling pathway played a regulatory role in the differentiation of lung epithelial cells and fibroblasts, and the pathogenesis of pulmonary fibrosis related to PQ. Inhibition of the Wnt/β-catenin signaling pathway may be investigated further as a potential fibrosis suppressor for pulmonary fibrosis therapy." @default.
- W3048854645 created "2020-08-18" @default.
- W3048854645 creator A5015107225 @default.
- W3048854645 creator A5025284547 @default.
- W3048854645 creator A5028091840 @default.
- W3048854645 creator A5047757729 @default.
- W3048854645 creator A5051610166 @default.
- W3048854645 creator A5064564309 @default.
- W3048854645 creator A5068975569 @default.
- W3048854645 creator A5069522797 @default.
- W3048854645 creator A5075482179 @default.
- W3048854645 creator A5091539744 @default.
- W3048854645 date "2020-10-01" @default.
- W3048854645 modified "2023-10-16" @default.
- W3048854645 title "Paraquat induces pulmonary fibrosis through Wnt/β-catenin signaling pathway and myofibroblast differentiation" @default.
- W3048854645 cites W1583292237 @default.
- W3048854645 cites W1918709511 @default.
- W3048854645 cites W1946914111 @default.
- W3048854645 cites W1964847767 @default.
- W3048854645 cites W1971085650 @default.
- W3048854645 cites W1975306683 @default.
- W3048854645 cites W1977437151 @default.
- W3048854645 cites W1978270439 @default.
- W3048854645 cites W1978825438 @default.
- W3048854645 cites W1983712244 @default.
- W3048854645 cites W1993600822 @default.
- W3048854645 cites W2003406295 @default.
- W3048854645 cites W2012698286 @default.
- W3048854645 cites W2012919091 @default.
- W3048854645 cites W2019431738 @default.
- W3048854645 cites W2026611807 @default.
- W3048854645 cites W2028457976 @default.
- W3048854645 cites W2037930731 @default.
- W3048854645 cites W2042097194 @default.
- W3048854645 cites W2043691868 @default.
- W3048854645 cites W2059114286 @default.
- W3048854645 cites W2060126259 @default.
- W3048854645 cites W2064271041 @default.
- W3048854645 cites W2071497196 @default.
- W3048854645 cites W2079019573 @default.
- W3048854645 cites W2097029475 @default.
- W3048854645 cites W2099870390 @default.
- W3048854645 cites W2105002488 @default.
- W3048854645 cites W2108729195 @default.
- W3048854645 cites W2125890978 @default.
- W3048854645 cites W2134203448 @default.
- W3048854645 cites W2138578148 @default.
- W3048854645 cites W2140386277 @default.
- W3048854645 cites W2143759076 @default.
- W3048854645 cites W2146765493 @default.
- W3048854645 cites W2322134651 @default.
- W3048854645 doi "https://doi.org/10.1016/j.toxlet.2020.08.004" @default.
- W3048854645 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32795487" @default.
- W3048854645 hasPublicationYear "2020" @default.
- W3048854645 type Work @default.
- W3048854645 sameAs 3048854645 @default.
- W3048854645 citedByCount "21" @default.
- W3048854645 countsByYear W30488546452021 @default.
- W3048854645 countsByYear W30488546452022 @default.
- W3048854645 countsByYear W30488546452023 @default.
- W3048854645 crossrefType "journal-article" @default.
- W3048854645 hasAuthorship W3048854645A5015107225 @default.
- W3048854645 hasAuthorship W3048854645A5025284547 @default.
- W3048854645 hasAuthorship W3048854645A5028091840 @default.
- W3048854645 hasAuthorship W3048854645A5047757729 @default.
- W3048854645 hasAuthorship W3048854645A5051610166 @default.
- W3048854645 hasAuthorship W3048854645A5064564309 @default.
- W3048854645 hasAuthorship W3048854645A5068975569 @default.
- W3048854645 hasAuthorship W3048854645A5069522797 @default.
- W3048854645 hasAuthorship W3048854645A5075482179 @default.
- W3048854645 hasAuthorship W3048854645A5091539744 @default.
- W3048854645 hasConcept C137620995 @default.
- W3048854645 hasConcept C142724271 @default.
- W3048854645 hasConcept C182819311 @default.
- W3048854645 hasConcept C185592680 @default.
- W3048854645 hasConcept C207865475 @default.
- W3048854645 hasConcept C2777491412 @default.
- W3048854645 hasConcept C2779324961 @default.
- W3048854645 hasConcept C2780559512 @default.
- W3048854645 hasConcept C2781244666 @default.
- W3048854645 hasConcept C30145163 @default.
- W3048854645 hasConcept C502942594 @default.
- W3048854645 hasConcept C62478195 @default.
- W3048854645 hasConcept C71924100 @default.
- W3048854645 hasConcept C86803240 @default.
- W3048854645 hasConcept C95444343 @default.
- W3048854645 hasConceptScore W3048854645C137620995 @default.
- W3048854645 hasConceptScore W3048854645C142724271 @default.
- W3048854645 hasConceptScore W3048854645C182819311 @default.
- W3048854645 hasConceptScore W3048854645C185592680 @default.
- W3048854645 hasConceptScore W3048854645C207865475 @default.
- W3048854645 hasConceptScore W3048854645C2777491412 @default.
- W3048854645 hasConceptScore W3048854645C2779324961 @default.
- W3048854645 hasConceptScore W3048854645C2780559512 @default.
- W3048854645 hasConceptScore W3048854645C2781244666 @default.
- W3048854645 hasConceptScore W3048854645C30145163 @default.
- W3048854645 hasConceptScore W3048854645C502942594 @default.
- W3048854645 hasConceptScore W3048854645C62478195 @default.