Matches in SemOpenAlex for { <https://semopenalex.org/work/W3048862045> ?p ?o ?g. }
Showing items 1 to 83 of
83
with 100 items per page.
- W3048862045 abstract "Aim Myocardial involvement in patients with systemic vasculitis portends a poorer prognosis. We sought to determine the extent of myocardial dysfunction in Granulomatosis with polyangitis and Churg Strauss disease using speckle tracking and strain imaging. Methods 20 patients and 22 controls with no prior cardiac history were recruited from December 2015 to April 2016. Baseline demographics recorded included age, sex, cardiovascular risk factors, time since diagnosis, immunosuppressive therapy and vasculitis damage index score (VDI). We performed transthoracic echocardiography using Vivid 7 GE machine along with twelve lead electrocardiograms (ECG) and biochemical analysis at the study visit. A single blinded operator utilising Echo Pac 11 software performed offline analysis of strain and speckle tracking measurements. Results Mean age of the vasculitis group was 56 ± 10 years with 50% being male, while mean age of controls was 53 ± 9 years with 55% male. There were no significant differences between groups in age, incidence of hypertension (p = 0.3) or diabetes (p = 0.6). Radial strain was significantly reduced in the vasculitis cohort (P = 0.05). The vasculitis cohort also showed a non-significant reduction in longitudinal strain and abnormal diastology as reflected in a reduction in tissue Doppler E’ velocities, decreased transmittal E/A ratio and increased E/E’ ratio when compared to controls (Table 1). There were negative correlations between increasing VDI score and reduction in mitral inflow velocities r = −0.5 (p = 0.02), number of clinical relapses and tissue Doppler E’ r = −0.6 (p = 0.009) and length of cyclophosphamide use with tissue Doppler E’ r = −0.5 (p = 0.02). Conclusion This is one of the largest studies investigating myocardial dysfunction in ANCA positive vasculitis. Patients demonstrated a reduction in radial strain and evidence of abnormal left ventricular relaxation. This may be indicative of underlying cardiac involvement." @default.
- W3048862045 created "2020-08-18" @default.
- W3048862045 creator A5009000278 @default.
- W3048862045 creator A5034423803 @default.
- W3048862045 creator A5037924021 @default.
- W3048862045 creator A5045641510 @default.
- W3048862045 creator A5046812181 @default.
- W3048862045 creator A5053213942 @default.
- W3048862045 creator A5056340261 @default.
- W3048862045 creator A5062148738 @default.
- W3048862045 date "2016-10-01" @default.
- W3048862045 modified "2023-09-28" @default.
- W3048862045 title "14 Myocardial dysfunction in ANCA vasculitis measured by two-dimensional speckle tracking echocardiography" @default.
- W3048862045 doi "https://doi.org/10.1136/heartjnl-2016-310523.14" @default.
- W3048862045 hasPublicationYear "2016" @default.
- W3048862045 type Work @default.
- W3048862045 sameAs 3048862045 @default.
- W3048862045 citedByCount "0" @default.
- W3048862045 crossrefType "journal-article" @default.
- W3048862045 hasAuthorship W3048862045A5009000278 @default.
- W3048862045 hasAuthorship W3048862045A5034423803 @default.
- W3048862045 hasAuthorship W3048862045A5037924021 @default.
- W3048862045 hasAuthorship W3048862045A5045641510 @default.
- W3048862045 hasAuthorship W3048862045A5046812181 @default.
- W3048862045 hasAuthorship W3048862045A5053213942 @default.
- W3048862045 hasAuthorship W3048862045A5056340261 @default.
- W3048862045 hasAuthorship W3048862045A5062148738 @default.
- W3048862045 hasConcept C120665830 @default.
- W3048862045 hasConcept C121332964 @default.
- W3048862045 hasConcept C126322002 @default.
- W3048862045 hasConcept C141071460 @default.
- W3048862045 hasConcept C164705383 @default.
- W3048862045 hasConcept C2776015282 @default.
- W3048862045 hasConcept C2777374719 @default.
- W3048862045 hasConcept C2778198053 @default.
- W3048862045 hasConcept C2778296771 @default.
- W3048862045 hasConcept C2779134260 @default.
- W3048862045 hasConcept C61511704 @default.
- W3048862045 hasConcept C71924100 @default.
- W3048862045 hasConcept C72563966 @default.
- W3048862045 hasConcept C78085059 @default.
- W3048862045 hasConceptScore W3048862045C120665830 @default.
- W3048862045 hasConceptScore W3048862045C121332964 @default.
- W3048862045 hasConceptScore W3048862045C126322002 @default.
- W3048862045 hasConceptScore W3048862045C141071460 @default.
- W3048862045 hasConceptScore W3048862045C164705383 @default.
- W3048862045 hasConceptScore W3048862045C2776015282 @default.
- W3048862045 hasConceptScore W3048862045C2777374719 @default.
- W3048862045 hasConceptScore W3048862045C2778198053 @default.
- W3048862045 hasConceptScore W3048862045C2778296771 @default.
- W3048862045 hasConceptScore W3048862045C2779134260 @default.
- W3048862045 hasConceptScore W3048862045C61511704 @default.
- W3048862045 hasConceptScore W3048862045C71924100 @default.
- W3048862045 hasConceptScore W3048862045C72563966 @default.
- W3048862045 hasConceptScore W3048862045C78085059 @default.
- W3048862045 hasLocation W30488620451 @default.
- W3048862045 hasOpenAccess W3048862045 @default.
- W3048862045 hasPrimaryLocation W30488620451 @default.
- W3048862045 hasRelatedWork W1935007963 @default.
- W3048862045 hasRelatedWork W2002070234 @default.
- W3048862045 hasRelatedWork W2004533444 @default.
- W3048862045 hasRelatedWork W2047084760 @default.
- W3048862045 hasRelatedWork W2079461557 @default.
- W3048862045 hasRelatedWork W2127249714 @default.
- W3048862045 hasRelatedWork W2151323466 @default.
- W3048862045 hasRelatedWork W2327116370 @default.
- W3048862045 hasRelatedWork W2485408098 @default.
- W3048862045 hasRelatedWork W2582267431 @default.
- W3048862045 hasRelatedWork W2770383743 @default.
- W3048862045 hasRelatedWork W2910219981 @default.
- W3048862045 hasRelatedWork W2951377124 @default.
- W3048862045 hasRelatedWork W2966132768 @default.
- W3048862045 hasRelatedWork W3035011216 @default.
- W3048862045 hasRelatedWork W3039272186 @default.
- W3048862045 hasRelatedWork W3113403029 @default.
- W3048862045 hasRelatedWork W3128871119 @default.
- W3048862045 hasRelatedWork W3211009861 @default.
- W3048862045 hasRelatedWork W3212530577 @default.
- W3048862045 hasVolume "102" @default.
- W3048862045 isParatext "false" @default.
- W3048862045 isRetracted "false" @default.
- W3048862045 magId "3048862045" @default.
- W3048862045 workType "article" @default.