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• W304886385 abstract "The self-organized morphogenesis of the vertebrate optic cup entails coupling the activation of the retinal gene regulatory network to the constriction-driven infolding of the retinal epithelium. Yet the genetic mechanisms underlying this coordination remain largely unexplored. Through phylogenetic footprinting and transgenesis in zebrafish, here we examine the cis-regulatory landscape of opo, an endocytosis regulator essential for eye morphogenesis. Among the different conserved enhancers identified, we isolate a single retina-specific element (H6_10137) and show that its activity depends on binding sites for the retinal determinant Vsx2. Gain- and loss-of-function experiments and ChIP analyses reveal that Vsx2 regulates opo expression through direct binding to this retinal enhancer. Furthermore, we show that vsx2 knockdown impairs the primary optic cup folding. These data support a model by which vsx2, operating through the effector gene opo, acts as a central transcriptional node that coordinates neural retina patterning and optic cup invagination in zebrafish. The transcriptional regulation of morphogenetic effectors during eye development is poorly understood. Here, the authors show that transcription of an endocytosis regulator Opois crucial for the neural retina development in zebrafish and activated by the interaction of the transcription factor Vsx2 and retinal enhancer H6_10137." @default.
• W304886385 created "2016-06-24" @default.
• W304886385 creator A5003733187 @default.
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• W304886385 date "2015-05-12" @default.
• W304886385 modified "2023-10-18" @default.
• W304886385 title "Analysis of opo cis-regulatory landscape uncovers Vsx2 requirement in early eye morphogenesis" @default.
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• W304886385 doi "https://doi.org/10.1038/ncomms8054" @default.
• W304886385 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25963169" @default.
• W304886385 hasPublicationYear "2015" @default.
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