FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3048863911> ?p ?o ?g. }

• W3048863911 abstract "Currently, the number of patients with COVID-19 has significantly increased. Thus, there is an urgent need for developing treatments for COVID-19. Drug repurposing, which is the process of reusing already-approved drugs for new medical conditions, can be a good way to solve this problem quickly and broadly. Many clinical trials for COVID-19 patients using treatments for other diseases have already been in place or will be performed at clinical sites in the near future. Additionally, patients with comorbidities such as diabetes mellitus, obesity, liver cirrhosis, kidney diseases, hypertension, and asthma are at higher risk for severe illness from COVID-19. Thus, the relationship of comorbidity disease with COVID-19 may help to find repurposable drugs. To reduce trial and error in finding treatments for COVID-19, we propose building a network-based drug repurposing framework to prioritize repurposable drugs. First, we utilized knowledge of COVID-19 to construct a disease-gene-drug network (DGDr-Net) representing a COVID-19-centric interactome with components for diseases, genes, and drugs. DGDr-Net consisted of 592 diseases, 26,681 human genes and 2,173 drugs, and medical information for 18 common comorbidities. The DGDr-Net recommended candidate repurposable drugs for COVID-19 through network reinforcement driven scoring algorithms. The scoring algorithms determined the priority of recommendations by utilizing graph-based semi-supervised learning. From the predicted scores, we recommended 30 drugs, including dexamethasone, resveratrol, methotrexate, indomethacin, quercetin, etc., as repurposable drugs for COVID-19, and the results were verified with drugs that have been under clinical trials. The list of drugs via a data-driven computational approach could help reduce trial-and-error in finding treatment for COVID-19." @default.
• W3048863911 created "2020-08-18" @default.
• W3048863911 creator A5005169879 @default.
• W3048863911 creator A5012994745 @default.
• W3048863911 creator A5014375228 @default.
• W3048863911 creator A5021269581 @default.
• W3048863911 creator A5028997621 @default.
• W3048863911 creator A5033220689 @default.
• W3048863911 creator A5050166537 @default.
• W3048863911 creator A5057054344 @default.
• W3048863911 creator A5078473635 @default.
• W3048863911 creator A5080198746 @default.
• W3048863911 date "2020-08-12" @default.
• W3048863911 modified "2023-10-17" @default.
• W3048863911 title "Network reinforcement driven drug repurposing for COVID-19 by exploiting disease-gene-drug associations" @default.
• W3048863911 cites W1983320747 @default.
• W3048863911 cites W2019707847 @default.
• W3048863911 cites W2131681506 @default.
• W3048863911 cites W2136504847 @default.
• W3048863911 cites W2767891136 @default.
• W3048863911 cites W2916047525 @default.
• W3048863911 cites W2963703678 @default.
• W3048863911 cites W3011056788 @default.
• W3048863911 cites W3011072970 @default.
• W3048863911 cites W3011439019 @default.
• W3048863911 cites W3013125498 @default.
• W3048863911 cites W3013336676 @default.
• W3048863911 cites W3014695022 @default.
• W3048863911 cites W3014850166 @default.
• W3048863911 cites W3015353977 @default.
• W3048863911 cites W3016084006 @default.
• W3048863911 cites W3016535995 @default.
• W3048863911 cites W3027280195 @default.
• W3048863911 cites W3031869734 @default.
• W3048863911 cites W3035205964 @default.
• W3048863911 cites W3039779697 @default.
• W3048863911 cites W3045082065 @default.
• W3048863911 doi "https://doi.org/10.48550/arxiv.2008.05377" @default.
• W3048863911 hasPublicationYear "2020" @default.
• W3048863911 type Work @default.
• W3048863911 sameAs 3048863911 @default.
• W3048863911 citedByCount "0" @default.
• W3048863911 crossrefType "posted-content" @default.
• W3048863911 hasAuthorship W3048863911A5005169879 @default.
• W3048863911 hasAuthorship W3048863911A5012994745 @default.
• W3048863911 hasAuthorship W3048863911A5014375228 @default.
• W3048863911 hasAuthorship W3048863911A5021269581 @default.
• W3048863911 hasAuthorship W3048863911A5028997621 @default.
• W3048863911 hasAuthorship W3048863911A5033220689 @default.
• W3048863911 hasAuthorship W3048863911A5050166537 @default.
• W3048863911 hasAuthorship W3048863911A5057054344 @default.
• W3048863911 hasAuthorship W3048863911A5078473635 @default.
• W3048863911 hasAuthorship W3048863911A5080198746 @default.
• W3048863911 hasBestOaLocation W30488639111 @default.
• W3048863911 hasConcept C103637391 @default.
• W3048863911 hasConcept C126322002 @default.
• W3048863911 hasConcept C177713679 @default.
• W3048863911 hasConcept C18903297 @default.
• W3048863911 hasConcept C2779134260 @default.
• W3048863911 hasConcept C2780035454 @default.
• W3048863911 hasConcept C519536355 @default.
• W3048863911 hasConcept C535046627 @default.
• W3048863911 hasConcept C71924100 @default.
• W3048863911 hasConcept C86803240 @default.
• W3048863911 hasConcept C98274493 @default.
• W3048863911 hasConceptScore W3048863911C103637391 @default.
• W3048863911 hasConceptScore W3048863911C126322002 @default.
• W3048863911 hasConceptScore W3048863911C177713679 @default.
• W3048863911 hasConceptScore W3048863911C18903297 @default.
• W3048863911 hasConceptScore W3048863911C2779134260 @default.
• W3048863911 hasConceptScore W3048863911C2780035454 @default.
• W3048863911 hasConceptScore W3048863911C519536355 @default.
• W3048863911 hasConceptScore W3048863911C535046627 @default.
• W3048863911 hasConceptScore W3048863911C71924100 @default.
• W3048863911 hasConceptScore W3048863911C86803240 @default.
• W3048863911 hasConceptScore W3048863911C98274493 @default.
• W3048863911 hasLocation W30488639111 @default.
• W3048863911 hasLocation W30488639112 @default.
• W3048863911 hasOpenAccess W3048863911 @default.
• W3048863911 hasPrimaryLocation W30488639111 @default.
• W3048863911 hasRelatedWork W3049299998 @default.
• W3048863911 hasRelatedWork W3050951227 @default.
• W3048863911 hasRelatedWork W3082713933 @default.
• W3048863911 hasRelatedWork W3159848998 @default.
• W3048863911 hasRelatedWork W4225380062 @default.
• W3048863911 hasRelatedWork W4240533889 @default.
• W3048863911 hasRelatedWork W4283755545 @default.
• W3048863911 hasRelatedWork W4293716749 @default.
• W3048863911 hasRelatedWork W4310838044 @default.
• W3048863911 hasRelatedWork W3099438243 @default.
• W3048863911 isParatext "false" @default.
• W3048863911 isRetracted "false" @default.
• W3048863911 magId "3048863911" @default.
• W3048863911 workType "article" @default.