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• W3048867517 abstract "Abstract Intracellular pathogens mobilize host signaling pathways of their host cell to promote their own survival. Evidence is emerging that signal transduction elements are activated in a-nucleated erythrocytes in response to infection with malaria parasites, but the extent of this phenomenon remains unknown. Here, we fill this knowledge gap through a comprehensive and dynamic assessment of host erythrocyte signaling during infection with Plasmodium falciparum . We used arrays of 878 antibodies directed against human signaling proteins to interrogate the activation status of host erythrocyte phospho-signaling pathways at three blood stages of parasite asexual development. This analysis reveals a dynamic modulation of many host signalling proteins across parasite development. Here we focus on the hepatocyte growth factor receptor (c-MET) and the MAP kinase pathway component B-Raf, providing a proof of concept that human signaling kinases identified as activated by malaria infection represent attractive targets for antimalarial intervention." @default.
• W3048867517 created "2020-08-18" @default.
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• W3048867517 date "2020-08-11" @default.
• W3048867517 modified "2023-10-16" @default.
• W3048867517 title "Analysis of erythrocyte signalling pathways during Plasmodium falciparum infection identifies targets for host-directed antimalarial intervention" @default.
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• W3048867517 doi "https://doi.org/10.1038/s41467-020-17829-7" @default.
• W3048867517 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7419518" @default.
• W3048867517 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32782246" @default.
• W3048867517 hasPublicationYear "2020" @default.
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