Matches in SemOpenAlex for { <https://semopenalex.org/work/W3048873045> ?p ?o ?g. }
- W3048873045 abstract "ABSTRACT Microtubule-interacting drugs, sometimes referred to as antimitotics, are used in cancer therapy to target and disrupt micro-tubules. However, their side effects require the development of safer drug regimens that still retain clinical efficacy. Currently, many questions remain regarding microtubule-interacting drugs at clinically relevant and ultra-low doses. Here, we use super-resolution microscopies (single molecule localization and optical fluctuation based) to reveal the initial microtubule dysfunctions caused by nanomolar concentrations of colcemid. Short exposure to 30 - 80 nM colcemid results in aberrant microtubule curvature while microtubule fragmentation is detected upon treatment with ≥100 nM colcemid. Remarkably, even ultra-low doses (5 hours at <20 nM) led to subtle but significant microtubule architecture remodeling and suppression of microtubule dynamics. These challenges to microtubule function represent less severe precursor perturbations compared to the established antimitotic effects of microtubule-interacting drugs, and therefore offer potential for improved understanding and design of anti-cancer agents." @default.
- W3048873045 created "2020-08-18" @default.
- W3048873045 creator A5013221698 @default.
- W3048873045 creator A5015762393 @default.
- W3048873045 creator A5023457100 @default.
- W3048873045 creator A5038905104 @default.
- W3048873045 creator A5041578201 @default.
- W3048873045 creator A5055107013 @default.
- W3048873045 creator A5088663502 @default.
- W3048873045 date "2020-08-14" @default.
- W3048873045 modified "2023-09-25" @default.
- W3048873045 title "Ultra-Low Colcemid Doses Induce Microtubule Dysfunction as Revealed by Super-Resolution Microscopy" @default.
- W3048873045 cites W1153335416 @default.
- W3048873045 cites W1540070193 @default.
- W3048873045 cites W1571155052 @default.
- W3048873045 cites W1657499324 @default.
- W3048873045 cites W1963691994 @default.
- W3048873045 cites W1968095901 @default.
- W3048873045 cites W1971579914 @default.
- W3048873045 cites W1972163440 @default.
- W3048873045 cites W1980147610 @default.
- W3048873045 cites W1982746572 @default.
- W3048873045 cites W1987050301 @default.
- W3048873045 cites W1987434946 @default.
- W3048873045 cites W1997444052 @default.
- W3048873045 cites W1998115472 @default.
- W3048873045 cites W2010856476 @default.
- W3048873045 cites W2015041713 @default.
- W3048873045 cites W2023637808 @default.
- W3048873045 cites W2026206754 @default.
- W3048873045 cites W2034513172 @default.
- W3048873045 cites W2042100002 @default.
- W3048873045 cites W2051600615 @default.
- W3048873045 cites W2055851342 @default.
- W3048873045 cites W2061422980 @default.
- W3048873045 cites W2068029176 @default.
- W3048873045 cites W2070835985 @default.
- W3048873045 cites W2078799104 @default.
- W3048873045 cites W2086397199 @default.
- W3048873045 cites W2092712606 @default.
- W3048873045 cites W2092956805 @default.
- W3048873045 cites W2093861156 @default.
- W3048873045 cites W2099540110 @default.
- W3048873045 cites W2113146347 @default.
- W3048873045 cites W2113187286 @default.
- W3048873045 cites W2115461488 @default.
- W3048873045 cites W2119657212 @default.
- W3048873045 cites W2140993877 @default.
- W3048873045 cites W2142825586 @default.
- W3048873045 cites W2146730043 @default.
- W3048873045 cites W2154747925 @default.
- W3048873045 cites W2163400016 @default.
- W3048873045 cites W2258453139 @default.
- W3048873045 cites W2319280819 @default.
- W3048873045 cites W2522853733 @default.
- W3048873045 cites W2523277769 @default.
- W3048873045 cites W2555858229 @default.
- W3048873045 cites W2610783744 @default.
- W3048873045 cites W2613581303 @default.
- W3048873045 cites W2761326476 @default.
- W3048873045 cites W2810467425 @default.
- W3048873045 cites W2894850729 @default.
- W3048873045 cites W2901096402 @default.
- W3048873045 cites W2920649201 @default.
- W3048873045 cites W2996972660 @default.
- W3048873045 doi "https://doi.org/10.1101/2020.08.13.249664" @default.
- W3048873045 hasPublicationYear "2020" @default.
- W3048873045 type Work @default.
- W3048873045 sameAs 3048873045 @default.
- W3048873045 citedByCount "0" @default.
- W3048873045 crossrefType "posted-content" @default.
- W3048873045 hasAuthorship W3048873045A5013221698 @default.
- W3048873045 hasAuthorship W3048873045A5015762393 @default.
- W3048873045 hasAuthorship W3048873045A5023457100 @default.
- W3048873045 hasAuthorship W3048873045A5038905104 @default.
- W3048873045 hasAuthorship W3048873045A5041578201 @default.
- W3048873045 hasAuthorship W3048873045A5055107013 @default.
- W3048873045 hasAuthorship W3048873045A5088663502 @default.
- W3048873045 hasBestOaLocation W30488730451 @default.
- W3048873045 hasConcept C12554922 @default.
- W3048873045 hasConcept C185592680 @default.
- W3048873045 hasConcept C20418707 @default.
- W3048873045 hasConcept C2776095844 @default.
- W3048873045 hasConcept C71924100 @default.
- W3048873045 hasConcept C86803240 @default.
- W3048873045 hasConcept C95444343 @default.
- W3048873045 hasConceptScore W3048873045C12554922 @default.
- W3048873045 hasConceptScore W3048873045C185592680 @default.
- W3048873045 hasConceptScore W3048873045C20418707 @default.
- W3048873045 hasConceptScore W3048873045C2776095844 @default.
- W3048873045 hasConceptScore W3048873045C71924100 @default.
- W3048873045 hasConceptScore W3048873045C86803240 @default.
- W3048873045 hasConceptScore W3048873045C95444343 @default.
- W3048873045 hasLocation W30488730451 @default.
- W3048873045 hasOpenAccess W3048873045 @default.
- W3048873045 hasPrimaryLocation W30488730451 @default.
- W3048873045 hasRelatedWork W1966031157 @default.
- W3048873045 hasRelatedWork W1977251101 @default.
- W3048873045 hasRelatedWork W2038471403 @default.
- W3048873045 hasRelatedWork W2063301562 @default.