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• W3048877314 abstract "Wavefront shaping is increasingly being used in modern microscopy to obtain distortion-free, high-resolution images deep inside inhomogeneous media. Wavefront shaping methods typically rely on the presence of a 'guidestar' in order to find the optimal wavefront to mitigate the scattering of light. However, this condition cannot be satisfied in most biomedical applications. Here, we introduce a novel, guidestar-free wavefront shaping method in which the optimal wavefront is computed using a digital model of the sample. The refractive index model of the sample, that serves as the input for the computation, is constructed in-situ by the microscope itself. In a proof of principle imaging experiment, we demonstrate a large improvement in the two-photon fluorescence signal through a diffuse medium, outperforming the state-of-the-art wavefront shaping techniques by a factor of 21." @default.
• W3048877314 created "2020-08-18" @default.
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• W3048877314 date "2020-09-10" @default.
• W3048877314 modified "2023-10-03" @default.
• W3048877314 title "Model-based wavefront shaping microscopy" @default.
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• W3048877314 doi "https://doi.org/10.1364/ol.400985" @default.
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