Matches in SemOpenAlex for { <https://semopenalex.org/work/W3048887029> ?p ?o ?g. }
- W3048887029 endingPage "102647" @default.
- W3048887029 startingPage "102647" @default.
- W3048887029 abstract "Abstract: Multiple sclerosis (MS) is an inflammatory demyelinating disease of the central nervous system (CNS) where immunopathology is thought to be mediated by myelin-reactive CD4+ T helper (TH) cells. The TH cells most commonly implicated in the pathogenesis of the disease are of TH1 and TH17 lineage, which are defined by the production of interferon-γ and interleukin-17, respectively. Moreover, there is emerging evidence for the involvement of TH17.1 cells, which share the hallmarks of TH1 and TH17 subsets. In this review, we summarise current knowledge about the potential role of TH17 subsets in the initiation and progression of the disease and put a focus on their response to approved immunomodulatory MS drugs. In this regard, TH17 cells are abundant in peripheral blood, cerebrospinal fluid and brain lesions of MS patients, and their counts and inflammatory mediators are further increased during relapses. Fingolimod and alemtuzumab induce a paramount decrease in central memory T cells, which harbour the majority of peripheral TH17 cells, while the efficacy of natalizumab, dimethyl fumarate and importantly hematopoietic stem cell therapy correlates with TH17.1 cell inhibition. Interestingly, also CD20 antibodies target highly inflammatory TH cells and hamper TH17 differentiation by IL-6 reductions. Moreover, recovery rates of TH cells best correlate with long-term efficacy after therapeutical immunodepletion. We conclude that central memory TH17.1 cells play a pivotal role in MS pathogenesis and they represent a major target of MS therapeutics." @default.
- W3048887029 created "2020-08-18" @default.
- W3048887029 creator A5044043401 @default.
- W3048887029 creator A5044375884 @default.
- W3048887029 creator A5053256015 @default.
- W3048887029 creator A5064261527 @default.
- W3048887029 creator A5090491021 @default.
- W3048887029 date "2020-10-01" @default.
- W3048887029 modified "2023-10-11" @default.
- W3048887029 title "The role of TH17 cells in multiple sclerosis: Therapeutic implications" @default.
- W3048887029 cites W1509473864 @default.
- W3048887029 cites W1514064771 @default.
- W3048887029 cites W1516263086 @default.
- W3048887029 cites W1525631190 @default.
- W3048887029 cites W1525680491 @default.
- W3048887029 cites W1574165260 @default.
- W3048887029 cites W1697354033 @default.
- W3048887029 cites W1763258797 @default.
- W3048887029 cites W1890836614 @default.
- W3048887029 cites W1967496127 @default.
- W3048887029 cites W1968607622 @default.
- W3048887029 cites W1979358011 @default.
- W3048887029 cites W1989091670 @default.
- W3048887029 cites W1993003564 @default.
- W3048887029 cites W1994939061 @default.
- W3048887029 cites W1998000193 @default.
- W3048887029 cites W1999906527 @default.
- W3048887029 cites W2003342633 @default.
- W3048887029 cites W2004522121 @default.
- W3048887029 cites W2006173610 @default.
- W3048887029 cites W2006249161 @default.
- W3048887029 cites W2012199003 @default.
- W3048887029 cites W2016624604 @default.
- W3048887029 cites W2017706704 @default.
- W3048887029 cites W2017893786 @default.
- W3048887029 cites W2019755314 @default.
- W3048887029 cites W2019926860 @default.
- W3048887029 cites W2021435584 @default.
- W3048887029 cites W2024366267 @default.
- W3048887029 cites W2024921751 @default.
- W3048887029 cites W2025464048 @default.
- W3048887029 cites W2026992198 @default.
- W3048887029 cites W2034107216 @default.
- W3048887029 cites W2035060162 @default.
- W3048887029 cites W2038255410 @default.
- W3048887029 cites W2042586707 @default.
- W3048887029 cites W2042865787 @default.
- W3048887029 cites W2045820436 @default.
- W3048887029 cites W2046128399 @default.
- W3048887029 cites W2046188285 @default.
- W3048887029 cites W2047825227 @default.
- W3048887029 cites W2050244205 @default.
- W3048887029 cites W2051474906 @default.
- W3048887029 cites W2054226526 @default.
- W3048887029 cites W2061815509 @default.
- W3048887029 cites W2074371432 @default.
- W3048887029 cites W2075417119 @default.
- W3048887029 cites W2076889715 @default.
- W3048887029 cites W2081444414 @default.
- W3048887029 cites W2091297000 @default.
- W3048887029 cites W2093853003 @default.
- W3048887029 cites W2095211506 @default.
- W3048887029 cites W2096243634 @default.
- W3048887029 cites W2098345971 @default.
- W3048887029 cites W2100941609 @default.
- W3048887029 cites W2102628016 @default.
- W3048887029 cites W2103477671 @default.
- W3048887029 cites W2107235439 @default.
- W3048887029 cites W2107369528 @default.
- W3048887029 cites W2112837750 @default.
- W3048887029 cites W2113577022 @default.
- W3048887029 cites W2116686907 @default.
- W3048887029 cites W2122082443 @default.
- W3048887029 cites W2123093300 @default.
- W3048887029 cites W2125701590 @default.
- W3048887029 cites W2126336004 @default.
- W3048887029 cites W2127568644 @default.
- W3048887029 cites W2129327924 @default.
- W3048887029 cites W2132968664 @default.
- W3048887029 cites W2133631499 @default.
- W3048887029 cites W2139314555 @default.
- W3048887029 cites W2142017607 @default.
- W3048887029 cites W2144013613 @default.
- W3048887029 cites W2145287186 @default.
- W3048887029 cites W2146702689 @default.
- W3048887029 cites W2151112628 @default.
- W3048887029 cites W2151290905 @default.
- W3048887029 cites W2154132418 @default.
- W3048887029 cites W2154775026 @default.
- W3048887029 cites W2154911070 @default.
- W3048887029 cites W2159252214 @default.
- W3048887029 cites W2160209245 @default.
- W3048887029 cites W2163280031 @default.
- W3048887029 cites W2167297937 @default.
- W3048887029 cites W2167739575 @default.
- W3048887029 cites W2171454895 @default.
- W3048887029 cites W2171556560 @default.
- W3048887029 cites W2171907184 @default.