FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3048889209> ?p ?o ?g. }

• W3048889209 endingPage "113224" @default.
• W3048889209 startingPage "113224" @default.
• W3048889209 abstract "Abstract Ethnopharmacological relevance Lophatherum gracile Brongn. (L. gracile) has been long used in traditional herbal medicine to clinically clear heat, disinhibit dampness, and treat inflammation. However, the effect of L. gracile on the activation of human neutrophils remains unclear. Aim of the study The aim of current study is to investigate the anti-inflammatory properties of L. gracile extract (LGE) in N-formyl-methionyl-leucyl-phenylalanine (fMLF)-induced activation of human neutrophils. Materials and methods Superoxide anion generation and elastase release were estimated by spectrophotometry. A series of signaling pathways including mitogen-activated protein kinases (MAPKs) and protein kinase B (Akt), as well as calcium mobilization were studied by Western blot analysis and spectrofluorometry. Results Our experimental results indicated that the nontoxic dosage of LGE does-dependently inhibited the fMLF-induced superoxide anion (O2•−) generation, elastase release, CD11b expression, adhesion, and chemotactic migration in human neutrophils. LGE selectively inhibited the fMLF-induced phosphorylation of JNK but not p38, ERK, or Akt in human neutrophils. LGE also decreased the intracellular Ca2+ levels ([Ca2+]i) in fMLF-activated human neutrophils. However, a specific JNK inhibitor inhibited the fMLF-induced O2•− generation and CD11b expression, but it had no effect on [Ca2+]i in human neutrophils. Conclusions LGE exhibited anti-inflammatory activities in fMLF-activated human neutrophils. The pharmacological mechanisms of LGE-repressed neutrophilic inflammation were through two independent pathways, JNK signaling and calcium mobilization. Our results suggested that LGE holds the potential to be developed as an anti-inflammatory botanical medicine." @default.
• W3048889209 created "2020-08-18" @default.
• W3048889209 creator A5000181327 @default.
• W3048889209 creator A5004501208 @default.
• W3048889209 creator A5011979934 @default.
• W3048889209 creator A5013330477 @default.
• W3048889209 creator A5014212972 @default.
• W3048889209 creator A5015303092 @default.
• W3048889209 creator A5052945329 @default.
• W3048889209 creator A5056420351 @default.
• W3048889209 creator A5059656597 @default.
• W3048889209 creator A5061974988 @default.
• W3048889209 creator A5066359340 @default.
• W3048889209 date "2021-01-01" @default.
• W3048889209 modified "2023-10-10" @default.
• W3048889209 title "Lophatherum gracile Brongn. attenuates neutrophilic inflammation through inhibition of JNK and calcium" @default.
• W3048889209 cites W1137212847 @default.
• W3048889209 cites W1970250409 @default.
• W3048889209 cites W1985629490 @default.
• W3048889209 cites W2004638361 @default.
• W3048889209 cites W2009571354 @default.
• W3048889209 cites W2043108620 @default.
• W3048889209 cites W2075653759 @default.
• W3048889209 cites W2076162988 @default.
• W3048889209 cites W2086603342 @default.
• W3048889209 cites W2086754759 @default.
• W3048889209 cites W2086782603 @default.
• W3048889209 cites W2101317681 @default.
• W3048889209 cites W2105268255 @default.
• W3048889209 cites W2115357715 @default.
• W3048889209 cites W2134625111 @default.
• W3048889209 cites W2148435201 @default.
• W3048889209 cites W2156978869 @default.
• W3048889209 cites W2159783017 @default.
• W3048889209 cites W2166432648 @default.
• W3048889209 cites W2188776204 @default.
• W3048889209 cites W2341534486 @default.
• W3048889209 cites W2419665627 @default.
• W3048889209 cites W2547345886 @default.
• W3048889209 cites W2587871687 @default.
• W3048889209 cites W2606513998 @default.
• W3048889209 cites W2607154592 @default.
• W3048889209 cites W2745518329 @default.
• W3048889209 cites W2755287478 @default.
• W3048889209 cites W2796011620 @default.
• W3048889209 cites W2805433484 @default.
• W3048889209 cites W2888792570 @default.
• W3048889209 cites W2889894889 @default.
• W3048889209 cites W2890828844 @default.
• W3048889209 cites W2895563103 @default.
• W3048889209 cites W2902336604 @default.
• W3048889209 cites W2910405444 @default.
• W3048889209 cites W2911237943 @default.
• W3048889209 cites W2971802501 @default.
• W3048889209 cites W2973759088 @default.
• W3048889209 cites W2980214381 @default.
• W3048889209 cites W4242005194 @default.
• W3048889209 doi "https://doi.org/10.1016/j.jep.2020.113224" @default.
• W3048889209 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32800928" @default.
• W3048889209 hasPublicationYear "2021" @default.
• W3048889209 type Work @default.
• W3048889209 sameAs 3048889209 @default.
• W3048889209 citedByCount "18" @default.
• W3048889209 countsByYear W30488892092021 @default.
• W3048889209 countsByYear W30488892092022 @default.
• W3048889209 countsByYear W30488892092023 @default.
• W3048889209 crossrefType "journal-article" @default.
• W3048889209 hasAuthorship W3048889209A5000181327 @default.
• W3048889209 hasAuthorship W3048889209A5004501208 @default.
• W3048889209 hasAuthorship W3048889209A5011979934 @default.
• W3048889209 hasAuthorship W3048889209A5013330477 @default.
• W3048889209 hasAuthorship W3048889209A5014212972 @default.
• W3048889209 hasAuthorship W3048889209A5015303092 @default.
• W3048889209 hasAuthorship W3048889209A5052945329 @default.
• W3048889209 hasAuthorship W3048889209A5056420351 @default.
• W3048889209 hasAuthorship W3048889209A5059656597 @default.
• W3048889209 hasAuthorship W3048889209A5061974988 @default.
• W3048889209 hasAuthorship W3048889209A5066359340 @default.
• W3048889209 hasConcept C126322002 @default.
• W3048889209 hasConcept C203014093 @default.
• W3048889209 hasConcept C2776914184 @default.
• W3048889209 hasConcept C519063684 @default.
• W3048889209 hasConcept C556039675 @default.
• W3048889209 hasConcept C71924100 @default.
• W3048889209 hasConcept C86803240 @default.
• W3048889209 hasConcept C98274493 @default.
• W3048889209 hasConceptScore W3048889209C126322002 @default.
• W3048889209 hasConceptScore W3048889209C203014093 @default.
• W3048889209 hasConceptScore W3048889209C2776914184 @default.
• W3048889209 hasConceptScore W3048889209C519063684 @default.
• W3048889209 hasConceptScore W3048889209C556039675 @default.
• W3048889209 hasConceptScore W3048889209C71924100 @default.
• W3048889209 hasConceptScore W3048889209C86803240 @default.
• W3048889209 hasConceptScore W3048889209C98274493 @default.
• W3048889209 hasFunder F4320311687 @default.
• W3048889209 hasFunder F4320322767 @default.
• W3048889209 hasFunder F4320322795 @default.
• W3048889209 hasLocation W30488892091 @default.

• next