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- W3048892125 endingPage "436" @default.
- W3048892125 startingPage "426" @default.
- W3048892125 abstract "Osteoarthritis (OA) is a joint degenerative disease that has become one of the leading causes of disability in the world. It is estimated that OA affects 50 million adults in the United States. Currently, there are no FDA-approved treatments that slow OA progression and its treatment is limited to pain management strategies and life style changes. Despite the discovery of several disease-modifying OA drugs (DMOADs) and promising results in preclinical studies, their clinical translation has been significantly limited because of poor intra-articular (IA) bioavailability and challenges in delivering these compounds to tissues of interest within the joint. Here, we review current OA treatments and their effectiveness at reducing joint pain, as well as novel targets for OA treatment and the challenges related to their clinical translation. Moreover, we discuss intra-articular (IA) drug delivery as a promising route of administration, describe its inherent challenges, and review recent advances in biomaterial-based IA drug delivery for OA treatment. Finally, we highlight the potential of tissue targeting in the development of effective IA drug delivery systems." @default.
- W3048892125 created "2020-08-18" @default.
- W3048892125 creator A5011208920 @default.
- W3048892125 creator A5013952860 @default.
- W3048892125 creator A5080019571 @default.
- W3048892125 date "2020-08-24" @default.
- W3048892125 modified "2023-10-14" @default.
- W3048892125 title "Biomaterial strategies for improved intra‐articular drug delivery" @default.
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