FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3048892799> ?p ?o ?g. }

• W3048892799 endingPage "1973" @default.
• W3048892799 startingPage "1965" @default.
• W3048892799 abstract "In this work, a new series of chemical isotope labeling reagents, levofloxacin-hydrazide-based mass tags (LHMTs) named as LHMT359/360/361/362/363/364/365/366/373/375/376/378/379/381 were first designed and synthesized for the high-throughput analysis of potential biomarkers containing hexanal and heptanal of lung cancer. We exploited a new core structure of levofloxacin-d3, which significantly enhanced the multiplexing capability. Among them, LHMT359 was used for labeling standard compounds as internal standards for quantification. Using LHMT373-heptanal as dummy template, dummy magnetic molecularly imprinted polymers (DMMIPs) were prepared for magnetic dispersive solid-phase extraction after derivatization procedure. Other 12 LHMTs were established for high-throughput labeling hexanal and heptanal in human serum samples. The presynthesized DMMIPs can selectively extract LHMTs-derivatives of hexanal and heptanal from equally mixed derivatization solutions. The enriched derivatives of hexanal and heptanal were quantified by ultrahigh-performance liquid chromatography tandem mass spectrometry (UHPLC–MS/MS). A single UHPLC–MS/MS run enabled simultaneously quantifying hexanal and heptanal from 12 serum samples only within 2 min. The limits of detection were all 0.5 pM for hexanal and heptanal. The accuracies from human serum samples ranged from −10.2% to +11.0% with the intra- and interday precisions less than 11.3%. Meanwhile, this method was successfully applied for the analysis of hexanal and heptanal in serum samples from healthy people and lung cancer patients. The results show that this method has the significant advantages of high sensitivity, accuracy, selectivity, and analysis-throughput. The method application indicates that the developed method is promising in the screening of suspected lung cancer patients." @default.
• W3048892799 created "2020-08-18" @default.
• W3048892799 creator A5002167398 @default.
• W3048892799 creator A5003234435 @default.
• W3048892799 creator A5019809018 @default.
• W3048892799 creator A5039189196 @default.
• W3048892799 creator A5040129697 @default.
• W3048892799 creator A5063242554 @default.
• W3048892799 creator A5073632229 @default.
• W3048892799 date "2020-08-12" @default.
• W3048892799 modified "2023-10-16" @default.
• W3048892799 title "13-Plex UHPLC–MS/MS Analysis of Hexanal and Heptanal Using Multiplex Tags Chemical Isotope Labeling Technology" @default.
• W3048892799 cites W1981008228 @default.
• W3048892799 cites W1983919959 @default.
• W3048892799 cites W2025639892 @default.
• W3048892799 cites W2026062068 @default.
• W3048892799 cites W2057522312 @default.
• W3048892799 cites W2106055476 @default.
• W3048892799 cites W2106628144 @default.
• W3048892799 cites W2151407626 @default.
• W3048892799 cites W2419442579 @default.
• W3048892799 cites W2460957491 @default.
• W3048892799 cites W2512639651 @default.
• W3048892799 cites W2593618931 @default.
• W3048892799 cites W2604368673 @default.
• W3048892799 cites W2884347863 @default.
• W3048892799 cites W2895842187 @default.
• W3048892799 cites W2898857317 @default.
• W3048892799 cites W2900229139 @default.
• W3048892799 cites W2905371244 @default.
• W3048892799 cites W2921101055 @default.
• W3048892799 cites W2927723121 @default.
• W3048892799 cites W2947502459 @default.
• W3048892799 cites W2948239348 @default.
• W3048892799 cites W2964813755 @default.
• W3048892799 cites W2966766130 @default.
• W3048892799 cites W2968519668 @default.
• W3048892799 cites W2969910647 @default.
• W3048892799 cites W2981245225 @default.
• W3048892799 cites W2985894004 @default.
• W3048892799 cites W2990739798 @default.
• W3048892799 cites W2991176085 @default.
• W3048892799 cites W2996290250 @default.
• W3048892799 cites W2996859627 @default.
• W3048892799 cites W2999902685 @default.
• W3048892799 cites W3020235869 @default.
• W3048892799 cites W3024486596 @default.
• W3048892799 cites W3025812695 @default.
• W3048892799 cites W3033261314 @default.
• W3048892799 doi "https://doi.org/10.1021/jasms.0c00222" @default.
• W3048892799 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32840365" @default.
• W3048892799 hasPublicationYear "2020" @default.
• W3048892799 type Work @default.
• W3048892799 sameAs 3048892799 @default.
• W3048892799 citedByCount "7" @default.
• W3048892799 countsByYear W30488927992021 @default.
• W3048892799 countsByYear W30488927992022 @default.
• W3048892799 countsByYear W30488927992023 @default.
• W3048892799 crossrefType "journal-article" @default.
• W3048892799 hasAuthorship W3048892799A5002167398 @default.
• W3048892799 hasAuthorship W3048892799A5003234435 @default.
• W3048892799 hasAuthorship W3048892799A5019809018 @default.
• W3048892799 hasAuthorship W3048892799A5039189196 @default.
• W3048892799 hasAuthorship W3048892799A5040129697 @default.
• W3048892799 hasAuthorship W3048892799A5063242554 @default.
• W3048892799 hasAuthorship W3048892799A5073632229 @default.
• W3048892799 hasConcept C161790260 @default.
• W3048892799 hasConcept C162356407 @default.
• W3048892799 hasConcept C178790620 @default.
• W3048892799 hasConcept C185592680 @default.
• W3048892799 hasConcept C2776418261 @default.
• W3048892799 hasConcept C2776923573 @default.
• W3048892799 hasConcept C2778353584 @default.
• W3048892799 hasConcept C2779825165 @default.
• W3048892799 hasConcept C43617362 @default.
• W3048892799 hasConceptScore W3048892799C161790260 @default.
• W3048892799 hasConceptScore W3048892799C162356407 @default.
• W3048892799 hasConceptScore W3048892799C178790620 @default.
• W3048892799 hasConceptScore W3048892799C185592680 @default.
• W3048892799 hasConceptScore W3048892799C2776418261 @default.
• W3048892799 hasConceptScore W3048892799C2776923573 @default.
• W3048892799 hasConceptScore W3048892799C2778353584 @default.
• W3048892799 hasConceptScore W3048892799C2779825165 @default.
• W3048892799 hasConceptScore W3048892799C43617362 @default.
• W3048892799 hasFunder F4320321001 @default.
• W3048892799 hasIssue "9" @default.
• W3048892799 hasLocation W30488927991 @default.
• W3048892799 hasLocation W30488927992 @default.
• W3048892799 hasOpenAccess W3048892799 @default.
• W3048892799 hasPrimaryLocation W30488927991 @default.
• W3048892799 hasRelatedWork W1963720419 @default.
• W3048892799 hasRelatedWork W1987886540 @default.
• W3048892799 hasRelatedWork W1988179438 @default.
• W3048892799 hasRelatedWork W2043095959 @default.
• W3048892799 hasRelatedWork W2047366894 @default.
• W3048892799 hasRelatedWork W2054281968 @default.
• W3048892799 hasRelatedWork W2072580689 @default.
• W3048892799 hasRelatedWork W2073733503 @default.

• next