FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3048894313> ?p ?o ?g. }

• W3048894313 endingPage "145057" @default.
• W3048894313 startingPage "145057" @default.
• W3048894313 abstract "COVID-19 is a lurking calamitous disease caused by an unusual virus, SARS-CoV-2, causing massive deaths worldwide. Nonetheless, explicit therapeutic drugs or clinically approved vaccines are not available for COVID-19. Thus, a comprehensive research is crucially needed to decode the pathogenic tools, plausible drug targets, committed to the development of efficient therapy. Host-pathogen interactions via host cellular components is an emerging field of research in this respect. miRNAs have been established as vital players in host-virus interactions. Moreover, viruses have the capability to manoeuvre the host miRNA networks according to their own obligations. Besides protein coding mRNAs, noncoding RNAs might also be targeted in infected cells and viruses can exploit the host miRNA network via ceRNA effect. We have predicted a ceRNA network involving one miRNA (miR-124-3p), one mRNA (Ddx58), one lncRNA (Gm26917) and two circRNAs (Ppp1r10, C330019G07RiK) in SARS-CoV infected cells. We have identified 4 DEGs-Isg15, Ddx58, Oasl1, Usp18 by analyzing a mRNA GEO dataset. There is no notable induction of IFNs and IFN-induced ACE2, significant receptor responsible for S-protein binding mediated viral entry. Pathway enrichment and GO analysis conceded the enrichment of pathways associated with interferon signalling and antiviral-mechanism by IFN-stimulated genes. Further, we have identified 3 noncoding RNAs, playing as potential ceRNAs to the genes associated with immune mechanisms. This integrative analysis has identified noncoding RNAs and their plausible targets, which could effectively enhance the understanding of molecular mechanisms associated with viral infection. However, validation of these targets is further corroborated to determine their therapeutic efficacy." @default.
• W3048894313 created "2020-08-18" @default.
• W3048894313 creator A5019926785 @default.
• W3048894313 creator A5039919375 @default.
• W3048894313 creator A5045576945 @default.
• W3048894313 creator A5070499132 @default.
• W3048894313 creator A5089253725 @default.
• W3048894313 date "2020-12-01" @default.
• W3048894313 modified "2023-10-03" @default.
• W3048894313 title "Unravelling host-pathogen interactions: ceRNA network in SARS-CoV-2 infection (COVID-19)" @default.
• W3048894313 cites W1546689286 @default.
• W3048894313 cites W1976483167 @default.
• W3048894313 cites W1978623713 @default.
• W3048894313 cites W1980389572 @default.
• W3048894313 cites W1989215732 @default.
• W3048894313 cites W2003471175 @default.
• W3048894313 cites W2017270642 @default.
• W3048894313 cites W2017408113 @default.
• W3048894313 cites W2019934186 @default.
• W3048894313 cites W2035618305 @default.
• W3048894313 cites W2049280733 @default.
• W3048894313 cites W2050843600 @default.
• W3048894313 cites W2051465752 @default.
• W3048894313 cites W2053510513 @default.
• W3048894313 cites W2064961188 @default.
• W3048894313 cites W2066944164 @default.
• W3048894313 cites W2069310363 @default.
• W3048894313 cites W2078646756 @default.
• W3048894313 cites W2086935788 @default.
• W3048894313 cites W2100267160 @default.
• W3048894313 cites W2117977572 @default.
• W3048894313 cites W2124153471 @default.
• W3048894313 cites W2135674505 @default.
• W3048894313 cites W2139945000 @default.
• W3048894313 cites W2141968121 @default.
• W3048894313 cites W2159675211 @default.
• W3048894313 cites W2167331352 @default.
• W3048894313 cites W2172557341 @default.
• W3048894313 cites W2255897570 @default.
• W3048894313 cites W2341128841 @default.
• W3048894313 cites W2345356016 @default.
• W3048894313 cites W2529603946 @default.
• W3048894313 cites W2572020026 @default.
• W3048894313 cites W2616524644 @default.
• W3048894313 cites W2760153273 @default.
• W3048894313 cites W2797547805 @default.
• W3048894313 cites W2804802143 @default.
• W3048894313 cites W2806778617 @default.
• W3048894313 cites W2897825874 @default.
• W3048894313 cites W2900569176 @default.
• W3048894313 cites W2931678155 @default.
• W3048894313 cites W2945883683 @default.
• W3048894313 cites W2948896704 @default.
• W3048894313 cites W2951523021 @default.
• W3048894313 cites W2980654983 @default.
• W3048894313 cites W2994085601 @default.
• W3048894313 cites W3004318991 @default.
• W3048894313 cites W3007643904 @default.
• W3048894313 cites W3007940623 @default.
• W3048894313 cites W3008028633 @default.
• W3048894313 cites W3009424226 @default.
• W3048894313 cites W3011134208 @default.
• W3048894313 cites W3015536776 @default.
• W3048894313 cites W3026015249 @default.
• W3048894313 doi "https://doi.org/10.1016/j.gene.2020.145057" @default.
• W3048894313 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7428439" @default.
• W3048894313 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32805314" @default.
• W3048894313 hasPublicationYear "2020" @default.
• W3048894313 type Work @default.
• W3048894313 sameAs 3048894313 @default.
• W3048894313 citedByCount "47" @default.
• W3048894313 countsByYear W30488943132020 @default.
• W3048894313 countsByYear W30488943132021 @default.
• W3048894313 countsByYear W30488943132022 @default.
• W3048894313 countsByYear W30488943132023 @default.
• W3048894313 crossrefType "journal-article" @default.
• W3048894313 hasAuthorship W3048894313A5019926785 @default.
• W3048894313 hasAuthorship W3048894313A5039919375 @default.
• W3048894313 hasAuthorship W3048894313A5045576945 @default.
• W3048894313 hasAuthorship W3048894313A5070499132 @default.
• W3048894313 hasAuthorship W3048894313A5089253725 @default.
• W3048894313 hasBestOaLocation W30488943131 @default.
• W3048894313 hasConcept C104317684 @default.
• W3048894313 hasConcept C126831891 @default.
• W3048894313 hasConcept C145059251 @default.
• W3048894313 hasConcept C159047783 @default.
• W3048894313 hasConcept C2522874641 @default.
• W3048894313 hasConcept C25602115 @default.
• W3048894313 hasConcept C2780718723 @default.
• W3048894313 hasConcept C54355233 @default.
• W3048894313 hasConcept C60365752 @default.
• W3048894313 hasConcept C62203573 @default.
• W3048894313 hasConcept C67705224 @default.
• W3048894313 hasConcept C70721500 @default.
• W3048894313 hasConcept C86803240 @default.
• W3048894313 hasConceptScore W3048894313C104317684 @default.
• W3048894313 hasConceptScore W3048894313C126831891 @default.
• W3048894313 hasConceptScore W3048894313C145059251 @default.

• next