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- W3048903908 abstract "Abstract Turn-on fluorescence imaging is routinely studied; however, turn-on chemiluminescence has been rarely explored for in vivo imaging. Herein, we report the design and validation of chemiluminescence probe ADLumin-1 as a turn-on probe for amyloid beta (Aβ) species. Two-photon imaging indicates that ADLumin-1 can efficiently cross the blood–brain barrier and provides excellent contrast for Aβ plaques and cerebral amyloid angiopathy. In vivo brain imaging shows that the chemiluminescence signal of ADLumin-1 from 5-month-old transgenic 5xFAD mice is 1.80-fold higher than that from the age-matched wild-type mice. Moreover, we demonstrate that it is feasible to further d ually- a mplify s ignal via c hemiluminescence r esonance e nergy t ransfer (DAS-CRET) using two non-conjugated smart probes (ADLumin-1 and CRANAD-3) in solutions, brain homogenates, and in vivo whole brain imaging. Our results show that DAS-CRET can provide a 2.25-fold margin between 5-month-old 5xFAD mice and wild type mice. We believe that our strategy could be extended to other aggregating-prone proteins." @default.
- W3048903908 created "2020-08-18" @default.
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- W3048903908 date "2020-08-13" @default.
- W3048903908 modified "2023-10-17" @default.
- W3048903908 title "Turn-on chemiluminescence probes and dual-amplification of signal for detection of amyloid beta species in vivo" @default.
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- W3048903908 doi "https://doi.org/10.1038/s41467-020-17783-4" @default.
- W3048903908 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7426431" @default.
- W3048903908 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32792510" @default.
- W3048903908 hasPublicationYear "2020" @default.
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