Matches in SemOpenAlex for { <https://semopenalex.org/work/W3048904028> ?p ?o ?g. }
- W3048904028 endingPage "1470" @default.
- W3048904028 startingPage "1462" @default.
- W3048904028 abstract "Coumarins constitute a relatively new class of inhibitors of the zinc enzyme carbonic anhydrase (CA, EC 4.2.1.1), possessing a unique inhibition mechanism, acting as prodrug inhibitors. They undergo the hydrolysis of the lactone ring mediated by the esterase activity of CA. The formed 2-hydroxy-cinnamic acids thereafter bind within a very particular part of the enzyme active site, at its entrance, where a high variability of amino acid residues among the different mammalian CA isoforms is present, and where other inhibitors classes were not seen bound earlier. This explains why coumarins are among the most isoform-selective CA inhibitors known to date among the many chemotypes endowed with such biological activity. As coumarins are widespread secondary metabolites in some bacteria, plants, fungi, and ascidians, many such compounds from various natural sources have been investigated for their CA inhibitory properties and for possible biomedical applications, mainly as anticancer agents targeting hypoxic tumours." @default.
- W3048904028 created "2020-08-18" @default.
- W3048904028 creator A5035013697 @default.
- W3048904028 date "2020-01-01" @default.
- W3048904028 modified "2023-10-15" @default.
- W3048904028 title "Coumarin carbonic anhydrase inhibitors from natural sources" @default.
- W3048904028 cites W1511344577 @default.
- W3048904028 cites W1968868035 @default.
- W3048904028 cites W1989137879 @default.
- W3048904028 cites W1991046311 @default.
- W3048904028 cites W1992534600 @default.
- W3048904028 cites W1998555394 @default.
- W3048904028 cites W2025766128 @default.
- W3048904028 cites W2027356017 @default.
- W3048904028 cites W2028094318 @default.
- W3048904028 cites W2030896797 @default.
- W3048904028 cites W2032899001 @default.
- W3048904028 cites W2036839577 @default.
- W3048904028 cites W2037128835 @default.
- W3048904028 cites W2041922953 @default.
- W3048904028 cites W2044486547 @default.
- W3048904028 cites W2045506684 @default.
- W3048904028 cites W2047178318 @default.
- W3048904028 cites W2057651134 @default.
- W3048904028 cites W2069623860 @default.
- W3048904028 cites W2075345867 @default.
- W3048904028 cites W2096769771 @default.
- W3048904028 cites W2101908524 @default.
- W3048904028 cites W2109701399 @default.
- W3048904028 cites W2113154138 @default.
- W3048904028 cites W2113396525 @default.
- W3048904028 cites W2128531001 @default.
- W3048904028 cites W2132182129 @default.
- W3048904028 cites W2150627175 @default.
- W3048904028 cites W2169128564 @default.
- W3048904028 cites W2186736649 @default.
- W3048904028 cites W2229363841 @default.
- W3048904028 cites W2289414610 @default.
- W3048904028 cites W2315734412 @default.
- W3048904028 cites W2325640592 @default.
- W3048904028 cites W2343283127 @default.
- W3048904028 cites W2396178688 @default.
- W3048904028 cites W2396563396 @default.
- W3048904028 cites W2409680049 @default.
- W3048904028 cites W2471456962 @default.
- W3048904028 cites W2513875593 @default.
- W3048904028 cites W2540663276 @default.
- W3048904028 cites W2578616343 @default.
- W3048904028 cites W2593626379 @default.
- W3048904028 cites W2619401543 @default.
- W3048904028 cites W2756712334 @default.
- W3048904028 cites W2783421922 @default.
- W3048904028 cites W2790750213 @default.
- W3048904028 cites W2792231238 @default.
- W3048904028 cites W2792428864 @default.
- W3048904028 cites W2795311681 @default.
- W3048904028 cites W2797246868 @default.
- W3048904028 cites W2802605869 @default.
- W3048904028 cites W2806162630 @default.
- W3048904028 cites W2861313348 @default.
- W3048904028 cites W2887621482 @default.
- W3048904028 cites W2888826396 @default.
- W3048904028 cites W2890127266 @default.
- W3048904028 cites W2891768838 @default.
- W3048904028 cites W2901821976 @default.
- W3048904028 cites W2944600762 @default.
- W3048904028 cites W2947077617 @default.
- W3048904028 cites W2949605107 @default.
- W3048904028 cites W2951789869 @default.
- W3048904028 cites W2969513321 @default.
- W3048904028 cites W2969995755 @default.
- W3048904028 cites W2971411365 @default.
- W3048904028 cites W2973557793 @default.
- W3048904028 cites W2973974748 @default.
- W3048904028 cites W2976143231 @default.
- W3048904028 cites W2976611740 @default.
- W3048904028 cites W2980250486 @default.
- W3048904028 cites W2986778637 @default.
- W3048904028 cites W3000433028 @default.
- W3048904028 cites W3000497554 @default.
- W3048904028 cites W3009702175 @default.
- W3048904028 cites W3011727570 @default.
- W3048904028 cites W3013496878 @default.
- W3048904028 cites W3014500359 @default.
- W3048904028 cites W3014746151 @default.
- W3048904028 cites W3017340976 @default.
- W3048904028 cites W3017868191 @default.
- W3048904028 cites W3018515775 @default.
- W3048904028 cites W3021193281 @default.
- W3048904028 cites W3024156832 @default.
- W3048904028 cites W3024441676 @default.
- W3048904028 doi "https://doi.org/10.1080/14756366.2020.1788009" @default.
- W3048904028 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7470141" @default.
- W3048904028 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32779543" @default.
- W3048904028 hasPublicationYear "2020" @default.
- W3048904028 type Work @default.
- W3048904028 sameAs 3048904028 @default.
- W3048904028 citedByCount "47" @default.