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• W3048907064 abstract "Introduction A novel on-line adaptive radiotherapy (ART) system based on O-ring linear accelerator (LINAC) and cone-beam CT (CBCT) was evaluated for treatment and management of head & neck (H&N) cancer in an emulated environment accessed via remote desktop connection. In this on-line ART system, organs-at-risk (OARs) and target contours and radiotherapy (RT) plans are semi-automatically generated based on the patient CBCT, expediting a typically hours-long RT planning session to under half an hour. In this paper, we describe our initial experiences with the system and explore optimization strategies to expedite the process further. Methods We retroactively studied five patients with head and neck cancers, treated 16-35 fractions to 50-70 Gys. For each patient, on-line ART was simulated with one planning CT and three daily CBCT images taken beginning, middle, and end of treatment (tx). Key OAR (mandible, parotids, and spinal cord) and target (planning target volume (PTV) = clinical target volume (CTV) + 3 mm margin) contours were auto-generated and adjusted as needed by therapist/dosimetrist and attending physician, respectively. Duration of OAR contouring, target contouring, and plan review was recorded. Key OAR auto-contours were qualitatively rated from 1 (unacceptable) - 5 (perfect OAR delineation), and then quantitatively compared to human-adjusted “ground truth” contours via dice similarity coefficient (DSC) and 95-percentile Hausdorff distance (HD95%). Once contours were approved, adapted RT plans were auto-generated for physician review. Simulated doses to OARs and targets from the adapted plan were compared to that from the original (un-adapted) plan. Results Median on-line ART planning duration in the remote emulated environment was 19 min 34 sec (range: 13 min 10 sec - 31 min 20 sec). Automated key OAR quality was satisfactory overall (98% scored ≥3; 82% ≥4), though mandible was rated lower than others (p < 0.05). Most key OARs and all targets were within 2 mm margin of human-adjusted contours, but a few parotid and spinal cord contours deviated up to 5 mm. Anatomical changes over tx course further increased auto-contour error (p < 0.05, ΔHD95% = 0.77 mm comparing start and end of tx). Further optimizing auto-contoured OAR and target quality could reduce the on-line treatment planning duration by ~5 min and ~4.5 min, respectively. Dosimetrically, adapted plan spared OARs at a rate much greater than random chance compared to the original plan (χ2 = 22.3, p << 0.001), while maintaining similar therapeutic dose to treatment target CTV (χ2 = 1.14, p > 0.05). In addition, a general decrease in accumulated OAR dose was observed with adaptation. Unsupervised adapted plans where contours were auto-generated without human review still spared OAR at a greater rate than the original plans, suggesting benefits of adaptation can be maintained even with some leniency in contour accuracy. Conclusion Feasibility of a novel, semi-automated on-line ART system for various head and neck (H&N) cancer sites was demonstrated in terms of treatment duration, dosimetric benefits, and automated contour accuracy in a remote emulator environment. Adaptive planning duration was clinically viable at 19 min and 34 sec, but further improvements in automated contour accuracy and performance improvements of plan auto-generation may reduce adaptive planning duration by up to 10 minutes." @default.
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• W3048907064 date "2020-08-11" @default.
• W3048907064 modified "2023-10-16" @default.
• W3048907064 title "Initial Evaluation of a Novel Cone-Beam CT-Based Semi-Automated Online Adaptive Radiotherapy System for Head and Neck Cancer Treatment – A Timing and Automation Quality Study" @default.
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• W3048907064 doi "https://doi.org/10.7759/cureus.9660" @default.
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