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• W3048908258 endingPage "453" @default.
• W3048908258 startingPage "453" @default.
• W3048908258 abstract "As prophylactic vaccine adjuvants for infectious diseases, cyclic dinucleotides (CDNs) induce safe, potent, long-lasting humoral and cellular memory responses in the systemic and mucosal compartments. As therapeutic cancer vaccine adjuvants, CDNs induce potent anti-tumor immunity, including cytotoxic T cells and NK cells activation that achieve durable regression in multiple mouse models of tumors. Clinical trials are ongoing to fulfill the promise of CDNs (ClinicalTrials.gov: NCT02675439, NCT03010176, NCT03172936, and NCT03937141). However, in October 2018, the first clinical data with Merck’s CDN MK-1454 showed zero activity as a monotherapy in patients with solid tumors or lymphomas (NCT03010176). Lately, the clinical trial from Aduro’s CDN ADU-S100 monotherapy was also disappointing (NCT03172936). The emerging hurdle in CDN vaccine development calls for a timely re-evaluation of our understanding on CDN vaccine adjuvants. Here, we review the status of CDN vaccine adjuvant research, including their superior adjuvant activities, in vivo mode of action, and confounding factors that affect their efficacy in humans. Lastly, we discuss the strategies to overcome the hurdle and advance promising CDN adjuvants in humans." @default.
• W3048908258 created "2020-08-18" @default.
• W3048908258 creator A5003342935 @default.
• W3048908258 creator A5024699628 @default.
• W3048908258 creator A5066665904 @default.
• W3048908258 date "2020-08-13" @default.
• W3048908258 modified "2023-10-11" @default.
• W3048908258 title "The Age of Cyclic Dinucleotide Vaccine Adjuvants" @default.
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