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• W3048931133 endingPage "52" @default.
• W3048931133 startingPage "29" @default.
• W3048931133 abstract "Abstract The focal adhesion kinase (FAK) and the proline‐rich tyrosine kinase 2‐beta (PYK2) are implicated in cancer progression and metastasis and represent promising biomarkers and targets for cancer therapy. FAK and PYK2 are recruited to focal adhesions (FAs) via interactions between their FA targeting (FAT) domains and conserved segments (LD motifs) on the proteins Paxillin, Leupaxin, and Hic‐5. A promising new approach for the inhibition of FAK and PYK2 targets interactions of the FAK domains with proteins that promote localization at FAs. Advances toward this goal include the development of surface plasmon resonance, heteronuclear single quantum coherence nuclear magnetic resonance (HSQC‐NMR) and fluorescence polarization assays for the identification of fragments or compounds interfering with the FAK‐Paxillin interaction. We have recently validated this strategy, showing that Paxillin mimicking polypeptides with 2 to 3 LD motifs displace FAK from FAs and block kinase‐dependent and independent functions of FAK, including downstream integrin signaling and FA localization of the protein p130Cas. In the present work we study by all‐atom molecular dynamics simulations the recognition of peptides with the Paxillin and Leupaxin LD motifs by the FAK‐FAT and PYK2‐FAT domains. Our simulations and free‐energy analysis interpret experimental data on binding of Paxillin and Leupaxin LD motifs at FAK‐FAT and PYK2‐FAT binding sites, and assess the roles of consensus LD regions and flanking residues. Our results can assist in the design of effective inhibitory peptides of the FAK‐FAT: Paxillin and PYK2‐FAT:Leupaxin complexes and the construction of pharmacophore models for the discovery of potential small‐molecule inhibitors of the FAK‐FAT and PYK2‐FAT focal adhesion based functions." @default.
• W3048931133 created "2020-08-18" @default.
• W3048931133 creator A5021020481 @default.
• W3048931133 creator A5021845096 @default.
• W3048931133 creator A5065006700 @default.
• W3048931133 creator A5070268749 @default.
• W3048931133 creator A5081986866 @default.
• W3048931133 date "2020-09-24" @default.
• W3048931133 modified "2023-10-14" @default.
• W3048931133 title "Recognition of <scp>LD</scp> motifs by the focal adhesion targeting domains of focal adhesion kinase and proline‐rich tyrosine kinase 2‐beta: Insights from molecular dynamics simulations" @default.
• W3048931133 cites W1549357029 @default.
• W3048931133 cites W1845618662 @default.
• W3048931133 cites W1972758026 @default.
• W3048931133 cites W1974625510 @default.
• W3048931133 cites W1976522797 @default.
• W3048931133 cites W1977135347 @default.
• W3048931133 cites W1977585994 @default.
• W3048931133 cites W1979717066 @default.
• W3048931133 cites W1984738107 @default.
• W3048931133 cites W1986946246 @default.
• W3048931133 cites W1988664861 @default.
• W3048931133 cites W1989718733 @default.
• W3048931133 cites W1990031371 @default.
• W3048931133 cites W1998704463 @default.
• W3048931133 cites W1999722793 @default.
• W3048931133 cites W2000983089 @default.
• W3048931133 cites W2010366812 @default.
• W3048931133 cites W2010499485 @default.
• W3048931133 cites W2010884689 @default.
• W3048931133 cites W2011276624 @default.
• W3048931133 cites W2017835622 @default.
• W3048931133 cites W2017947288 @default.
• W3048931133 cites W2021520922 @default.
• W3048931133 cites W2021705436 @default.
• W3048931133 cites W2026038112 @default.
• W3048931133 cites W2036183783 @default.
• W3048931133 cites W2038758364 @default.
• W3048931133 cites W2044423100 @default.
• W3048931133 cites W2047730466 @default.
• W3048931133 cites W2048444562 @default.
• W3048931133 cites W2051209895 @default.
• W3048931133 cites W2052639416 @default.
• W3048931133 cites W2058052041 @default.
• W3048931133 cites W2063284791 @default.
• W3048931133 cites W2065101872 @default.
• W3048931133 cites W2067174909 @default.
• W3048931133 cites W2068652698 @default.
• W3048931133 cites W2070035704 @default.
• W3048931133 cites W2072583244 @default.
• W3048931133 cites W2078869352 @default.
• W3048931133 cites W2081135891 @default.
• W3048931133 cites W2081781663 @default.
• W3048931133 cites W2088129765 @default.
• W3048931133 cites W2094550032 @default.
• W3048931133 cites W2095277016 @default.
• W3048931133 cites W2101025132 @default.
• W3048931133 cites W2102376488 @default.
• W3048931133 cites W2107342944 @default.
• W3048931133 cites W2109154308 @default.
• W3048931133 cites W2110161012 @default.
• W3048931133 cites W2112418598 @default.
• W3048931133 cites W2112630221 @default.
• W3048931133 cites W2115100948 @default.
• W3048931133 cites W2116312858 @default.
• W3048931133 cites W2117092343 @default.
• W3048931133 cites W2126978201 @default.
• W3048931133 cites W2132262459 @default.
• W3048931133 cites W2134731229 @default.
• W3048931133 cites W2150981663 @default.
• W3048931133 cites W2151225825 @default.
• W3048931133 cites W2156451315 @default.
• W3048931133 cites W2157281740 @default.
• W3048931133 cites W2165915920 @default.
• W3048931133 cites W2267354756 @default.
• W3048931133 cites W2294118174 @default.
• W3048931133 cites W2310034942 @default.
• W3048931133 cites W2316175136 @default.
• W3048931133 cites W2409901341 @default.
• W3048931133 cites W2410448887 @default.
• W3048931133 cites W2644495484 @default.
• W3048931133 cites W2743553234 @default.
• W3048931133 cites W2775554376 @default.
• W3048931133 cites W2806313922 @default.
• W3048931133 cites W2899266085 @default.
• W3048931133 cites W2900521824 @default.
• W3048931133 cites W2914284294 @default.
• W3048931133 cites W2972376743 @default.
• W3048931133 cites W2972830360 @default.
• W3048931133 cites W2984343209 @default.
• W3048931133 cites W2997040555 @default.
• W3048931133 cites W3008175582 @default.
• W3048931133 cites W625615908 @default.
• W3048931133 doi "https://doi.org/10.1002/prot.25992" @default.
• W3048931133 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32776636" @default.
• W3048931133 hasPublicationYear "2020" @default.
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