FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3048947964> ?p ?o ?g. }

• W3048947964 endingPage "1583" @default.
• W3048947964 startingPage "1575" @default.
• W3048947964 abstract "Abstract In-situ analytical methods are essential for the reliable observation of peptide reactions without perturbation of the system. In this work, a real-time in-situ NMR analysis was performed to gain insight into the initial stage of the aggregation of amyloid-beta (Aβ) 8–25 monomers, S 8 GY 10 EVHHQKLVFF 20 AEDVG 25 , in solution prior to the fibril formation. NMR chemical shift and intensity changes in combination with the CD spectra revealed no changes in Aβ secondary structure, but the presence of soluble, oligomeric intermediates followed by the appearance of insoluble and non-structured aggregates before β-fibril formation. Molecular views of intermediates and aggregation mechanisms were proposed in comparison with NMR spectral changes in wild-type Aβ 8–25 and its two mutants, A21G and E22G. The mutation of just one amino acid modified the aggregation properties of Aβ 8–25; it slowed or accelerated the fibril formation by controlling the progress of conversion from monomer to aggregate via a soluble, small oligomer." @default.
• W3048947964 created "2020-08-18" @default.
• W3048947964 creator A5059475505 @default.
• W3048947964 creator A5085354315 @default.
• W3048947964 date "2020-08-03" @default.
• W3048947964 modified "2023-10-15" @default.
• W3048947964 title "Real-time in-situ ¹H NMR of reactions in peptide solution: preaggregation of amyloid-β fragments prior to fibril formation" @default.
• W3048947964 cites W1941577822 @default.
• W3048947964 cites W1961186421 @default.
• W3048947964 cites W2005571067 @default.
• W3048947964 cites W2020397423 @default.
• W3048947964 cites W2021064682 @default.
• W3048947964 cites W2025200427 @default.
• W3048947964 cites W2029695041 @default.
• W3048947964 cites W2030325989 @default.
• W3048947964 cites W2030343674 @default.
• W3048947964 cites W2046195832 @default.
• W3048947964 cites W2047056023 @default.
• W3048947964 cites W2052096376 @default.
• W3048947964 cites W2060910077 @default.
• W3048947964 cites W2062820102 @default.
• W3048947964 cites W2067214887 @default.
• W3048947964 cites W2079031778 @default.
• W3048947964 cites W2081855136 @default.
• W3048947964 cites W2095674336 @default.
• W3048947964 cites W2110101020 @default.
• W3048947964 cites W2118280241 @default.
• W3048947964 cites W2131819352 @default.
• W3048947964 cites W2277679914 @default.
• W3048947964 cites W2284359869 @default.
• W3048947964 cites W2319987871 @default.
• W3048947964 cites W2325973372 @default.
• W3048947964 cites W2474799636 @default.
• W3048947964 cites W2590966550 @default.
• W3048947964 cites W2606727285 @default.
• W3048947964 cites W2607479327 @default.
• W3048947964 cites W2782075983 @default.
• W3048947964 cites W2817784260 @default.
• W3048947964 cites W2914179168 @default.
• W3048947964 cites W2925878489 @default.
• W3048947964 cites W2945578042 @default.
• W3048947964 cites W2949250147 @default.
• W3048947964 cites W896868469 @default.
• W3048947964 doi "https://doi.org/10.1515/pac-2019-1201" @default.
• W3048947964 hasPublicationYear "2020" @default.
• W3048947964 type Work @default.
• W3048947964 sameAs 3048947964 @default.
• W3048947964 citedByCount "3" @default.
• W3048947964 countsByYear W30489479642022 @default.
• W3048947964 countsByYear W30489479642023 @default.
• W3048947964 crossrefType "journal-article" @default.
• W3048947964 hasAuthorship W3048947964A5059475505 @default.
• W3048947964 hasAuthorship W3048947964A5085354315 @default.
• W3048947964 hasBestOaLocation W30489479641 @default.
• W3048947964 hasConcept C103319777 @default.
• W3048947964 hasConcept C121332964 @default.
• W3048947964 hasConcept C12554922 @default.
• W3048947964 hasConcept C1276947 @default.
• W3048947964 hasConcept C136238340 @default.
• W3048947964 hasConcept C142724271 @default.
• W3048947964 hasConcept C166940927 @default.
• W3048947964 hasConcept C178790620 @default.
• W3048947964 hasConcept C179104552 @default.
• W3048947964 hasConcept C185592680 @default.
• W3048947964 hasConcept C188027245 @default.
• W3048947964 hasConcept C27523624 @default.
• W3048947964 hasConcept C2777633098 @default.
• W3048947964 hasConcept C2777822432 @default.
• W3048947964 hasConcept C2779134260 @default.
• W3048947964 hasConcept C2779281246 @default.
• W3048947964 hasConcept C2780642029 @default.
• W3048947964 hasConcept C2994168385 @default.
• W3048947964 hasConcept C3019447875 @default.
• W3048947964 hasConcept C4839761 @default.
• W3048947964 hasConcept C515207424 @default.
• W3048947964 hasConcept C521977710 @default.
• W3048947964 hasConcept C55493867 @default.
• W3048947964 hasConcept C67787023 @default.
• W3048947964 hasConcept C71240020 @default.
• W3048947964 hasConcept C71924100 @default.
• W3048947964 hasConcept C8010536 @default.
• W3048947964 hasConcept C86803240 @default.
• W3048947964 hasConceptScore W3048947964C103319777 @default.
• W3048947964 hasConceptScore W3048947964C121332964 @default.
• W3048947964 hasConceptScore W3048947964C12554922 @default.
• W3048947964 hasConceptScore W3048947964C1276947 @default.
• W3048947964 hasConceptScore W3048947964C136238340 @default.
• W3048947964 hasConceptScore W3048947964C142724271 @default.
• W3048947964 hasConceptScore W3048947964C166940927 @default.
• W3048947964 hasConceptScore W3048947964C178790620 @default.
• W3048947964 hasConceptScore W3048947964C179104552 @default.
• W3048947964 hasConceptScore W3048947964C185592680 @default.
• W3048947964 hasConceptScore W3048947964C188027245 @default.
• W3048947964 hasConceptScore W3048947964C27523624 @default.
• W3048947964 hasConceptScore W3048947964C2777633098 @default.
• W3048947964 hasConceptScore W3048947964C2777822432 @default.
• W3048947964 hasConceptScore W3048947964C2779134260 @default.
• W3048947964 hasConceptScore W3048947964C2779281246 @default.

• next